IBRAHIM A. ALSARRA, Ph.D.
Professor of Pharmaceutics & Pharmaceutical Biotechnology
Personal Data:
Department of Pharmaceutics Home: P.O. Box 34836 College of Pharmacy Riyadh 11478 Building # 23 Saudi Arabia Ground Floor, Office # AA 90 King Saud University P.O. Box 2457, Riyadh 11451, Saudi Arabia +(966)-1- 467-7504 (Office) +(966)-1- 467-6295 (Fax) +(966)-1- 467-3139 (Laboratory) E-mail:[email protected] Website: http://faculty.ksu.edu.sa/alsarra/default.aspx Education:
May 1998-May 2002 Doctor of Philosophy (Ph.D.) in Pharmaceutical
Biotechnology and Drug Formulation Development, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Missouri 64110-2265, USA.
Dissertation: “Preparation and Characterization of Chitosan Containing Hydrogel Beads for Immobilization of Candida Rugosa Lipase with High Retention of its Hydrolytic Activity”. Director:Professor Steven Henry Neau. May 1998-May 2002 Graduate Research Assistant, School of Pharmacy, Division of Pharmaceutical Sciences, University of Missouri-Kansas City, Missouri 64110-2265, USA. Responsibility:Planning, designing, executing experiments and analyzing results. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Education (continued):
October 1996-May 1998 Graduate Research Assistant, College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA. Responsibility:Planning, designing, executing experiments and analyzing results. 1995-1996 Graduate Teaching Assistant, College of Pharmacy,
Department of Pharmaceutics, King Saud University, P.O. Box 2457 Riyadh 11451, Saudi Arabia.
Responsibility:Teaching pharmacy undergraduate students, (Pharmaceutics, Computers, Pharmacokinetics and Biopharmaceutics, Simulation Pharmacy Laboratory).
1991-1996 Bachelor of Pharmacy (B.S.), College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. Professional Experience: December 2009-Present Professor, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. May 2006- December 2009 Associate Professor, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. June 2002-April 2006 Assistant Professor, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Employment: May 2009 - Present Deputy Director for Research and Technical Affairs,
Center of Excellence in Biotechnology Research, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Responsibility: Establishing, designing, implementing
technical affairs as well as responsible for supervising the Center Scientific Committee.
. September 2006-May 2007 Consultant, Executive Administration Training and
Academic Affairs, King Fahd Medical City, Ministry of Health, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
Responsibility: Establishing, designing, implementing
and evaluating Doctor of Pharmacy (Pharm.D.) Program and other pharmacy related academic and training programs for pharmacists, King Fahd Medical City, Ministry of Health, Riyadh, Saudi Arabia.
. May 2006-September 2006 Director of Pharmacy ServicesDepartment, King
Fahd Medical City, Ministry of Health, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
August 2004-May 2006 Consultant, Ministry of Health, King Fahd Medical City, Pharmacy Services Department, P.O. Box 59046, Riyadh
June 2004-Present Member, Academic Accreditation and Assessment
Committee, National Commission for Academic Accreditation and Assessment (NCAAA), Ministry of Higher Education, Riyadh, Saudi Arabia.
Responsibility: Evaluating the academic programs and Curricula of Ministry of Health's Institutes and Colleges. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Employment (continued): April 2004-April 2006 Vice-Dean for Administrative Affairs, College of
Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Responsibility: Oversee planning, implementation, and review of all academic majors and programs. Prepare the budget for academic programs and personnel: 100 full-time faculty and staff. Work with the division chairs and senior staff of the College to develop strategic planning. Professional and Honorary Memberships:
American Association of Pharmaceutical Scientists (AAPS)
The Rho Chi Society, 2001, University of Missouri-
Phi Beta Delta, National Honor Society for International Students and Scholars, 2001, University of Missouri-Kansas City, Missouri 64110-2265, USA.
Omicron Delta Kappa, National Leadership Honor Society, 2001, University of Missouri-Kansas City, Missouri 64110-2265, USA.
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Awards, Citations and Honors: June 2009 Recipient of King Saud University’s Award for
Distinguished Research and High-quality International Publications by faculty members across the University (2009), King Saud University, Riyadh, Saudi Arabia. 2009 Recipient of Dr. Waleed Kayyali’s Prize for Excellence
of Research in Pharmaceutical Sciences (2009), Saudi Pharmaceutical Society, Riyadh, Saudi Arabia. 2008-2009(2000) Outstanding Scientists, International Biographical 2008 Leading Scientists of the World (2008), Research and
Editorial Departments, International Biographical Centre, Cambridge, England.
2006-2007 Who's Who in Science and Engineering (2007),
distinguished as of the leading industry professionals from around the world.
2007 International Scientist of the Year (2007), International
Biographical Center, Cambridge, England.
2005-2006
Honored Members of Marquis Who’s Who in the World.
2002-2003 Honored Members of Strathmore Who’s Who in the
3/3/2003 Recipient of his Royal Highness Prince Bandar Bin Sultan, Saudi Ambassador to the USA, for outstanding academic achievement during Doctoral studies, 2003. 8/4/2001-Present Rho Chi Society, the Pharmacy Honor Society, 2000
University of Missouri-Kansas City, Missouri 64110- 2265, USA (Academic Honor). 1997-2002
Scholarship award from King Saud University, Ministry
of Higher Education, and Riyadh, Saudi Arabia to obtain Doctor of Philosophy (Ph.D.) degree from USA.
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Faculty and Administrative Responsibilities:
2010-Present Management BoardMember, Center of Excellence in Biotechnology Research, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia. 2010-2012 Management BoardMember, Student’s Fund Council, Deanship of Student Affairs, King Saud University. 2009-2011 Chairman,
Pharmaceutics, College of Pharmacy, King Saud University.
2009-2011 Member, Laboratory Supplies Committee, Department of Pharmaceutics, College of Pharmacy, King Saud University. 2008-2009
Pharmaceutics, College of Pharmacy, King Saud University.
2008-2009 Member, Laboratory Supplies Committee, Department of Pharmaceutics, College of Pharmacy, King Saud University. 2007-2008 Member, Laboratory Supplies Committee, Department of Pharmaceutics, College of Pharmacy, King Saud University.
2004-2006 Vice-Dean for Administrative Affairs, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
2004-2006 Member, College Council, College of Pharmacy, King Saud University.
2004-2006 Member, Research Center Council, College of Pharmacy, King Saud University. 2004-2006 Chairman, Pharmacy Student Training Committee, College of Pharmacy, King Saud University.
2004-2006 Chairman, Graduate Students’ Research Proposals Review Committee, Department of Pharmaceutics, College of Pharmacy, King Saud University. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Faculty and Administrative Responsibilities (continued): 2004-2006 Member, Pharmacy Students Academic Affairs, College of Pharmacy, King Saud University. April 2004 Chairman, Organizing Committee for the 5th University and Society Week and Exhibition, College of Pharmacy, King Saud University.
2004-2006 Communication Officer, Coordination between College of Pharmacy, King Saud University and the Scientific Offices, Medical Committee, Saudi Chamber. 2003-2004 Coordinator, Pharmacy Student Training Committee, College of Pharmacy, King Saud University. 2003-2004 Chairman, Social and Educational Committees, College of Pharmacy, King Saud University. 2003-2004 Chairman, Annual Report Committee, College of Pharmacy, King Saud University. 2003-2004 Coordinator,
Pharmaceutics, College of Pharmacy, King Saud University.
2003-2006 Member, Curriculum Revision Committee, College of Pharmacy, King Saud University. 2002-2004 Member, Academic and Postgraduate Studies Affairs Committee, Department of Pharmaceutics, College of Pharmacy, King Saud University. 2002-2004 Member, Laboratory Supplies Committee, Department of Pharmaceutics, College of Pharmacy, King Saud University. 2002-2004
Pharmaceutics, College of Pharmacy, King Saud University.
2002-2005 Member, Co-ordination Committee for Pharmacy Students’ Training between College of Pharmacy, King Saud University and various governmental and private sectors hospitals. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Faculty and Administrative Responsibilities (continued): 2002-2003 Member, Annual Report Committee, College of Pharmacy, King Saud University. 2002-2003 Member, Final Exams Organizing Committee, College of Pharmacy, King Saud University. 2002-2003 Member, Organizing Committee for the 2nd Drug Education Exhibition, College of Pharmacy, King Saud University. 2002-2003 Member, Medical Colleges Admission Committee for interviewing
undergraduate programs at the medical colleges (Medicine, Dentistry, Pharmacy, and Applied Medical Sciences Colleges), King Saud University.
2002-2004
Committee for selecting candidates for admission in the undergraduate programs at the medical colleges (Medicine, Dentistry, Pharmacy, and Applied Medical Sciences Colleges), King Saud University.
Workshops and Specialized Training: July 10-Spet. 10, 2009 Visiting Professor, Department of Pharmaceutical and
Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602-2352, USA.
April 20-22, 2009 Pharma and Biotech Opportunities in Emerging Markets,
Dubai International Convention and Exhibition Center, Dubai, United Arab Emirates.
April 20-22, 2009 Current Trends in Pharmaceuticals and Biotechnology,
Dubai International Convention and Exhibition Center, Dubai, United Arab Emirates.
January 26-28, 2009 Pharmaceutical Manufacturing Sciences Advances in
Sterile Products, Kyyali’s Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Workshops and Specialized Training (continued): November 10-13, 2008 Nanostructured Advanced Materials Workshop, A co-
joined program organized University of Jordan in Amman, Jordan and National Science Foundation, Washington, DC, USA.
June 2004
Advances in Controlled Release Technology: Polymeric Delivery Systems for Pharmaceuticals, Proteins and Other
Massachusetts Institute of Technology, Boston, USA.
October 1998 – October 1999 Advanced Cell Culture Techniques, Professor Ashim K.
Mitra Laboratories, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
December 1997
Handling Chemicals and Biohazard Materials Workshop, University of Kentucky. Lexington, Kentucky, USA.
February 1997
Radiation Safety Workshop, University of Kentucky. Lexington, Kentucky, USA.
October 1996
Laboratory Safety Workshop, University of Kentucky. Lexington, Kentucky, USA.
Other Scientific Activities: 2009 - Present Coordinator,
Excellence in Biotechnology Research, King Saudi University, Riyadh, Saudi Arabia.
February 16 -18, 2009 Member, Organizing Committee for the 1st International
Conference in Biotechnology (Towards Knowledge – Based Economy), Center of Excellence in Biotechnology Research, King Saudi University, Riyadh, Saudi Arabia, 16-18, 2009.
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Other Scientific Activities (continued): December 17 -21, 2005 Chairman,
International Pharmaceutical Sciences Conference and the 9th General Assembly Meeting of Scientific Society of the College of Pharmacy of the Association Arab Universities in the Arab World, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 17-21, 2005.
December 17 -21,2005 Member, Scientific Committee for the 9th International Pharmaceutical Sciences Conference and the 9th General Assembly Meeting of Scientific Society of the College of Pharmacy of the Association Arab Universities in the Arab World, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. February 16 -18, 2009 Moderator, Scientific Session: Vaccine Production, for
the 1st International Conference in Biotechnology (Towards Knowledge – Based Economy), Center of Excellence in Biotechnology Research, King Saudi University, Riyadh, Saudi Arabia, 16-18, 2009.
May 21- 23, 2005 Chairperson, Scientific Session: Biopharmaceutical
Development I, Saudi Biotechnology International Conference and Exhibition (Saudi-Bio 2004), King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia,
2002 - 2003 Member, Bioequivalence Study Team for Doxycycline (Riyadh Pharma Company, Riyadh, Saudi Arabia). Editorial Experience: 2009-Present Reviewer, Journal of Chromatographic Science 2009-Present Reviewer, Pharmaceutical Development and Technology 2009-Present Reviewer, AAPS Journal Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Editorial Experience (continued): 2009-Present Reviewer, AAPS PharmSciTech 2007-Present Reviewer, Molecular Pharmaceutics 2005-Present Editorial Board Member, Current Drug Therapy 2005-Present Reviewer, Arab Journal of Pharmaceutical Sciences 2005-Present Reviewer, Drug Development and Industrial Pharmacy
2005-Present Reviewer, International Journal of Pharmaceutics 2003-Present Reviewer, Journal of Polymer Research
2004-Present Editorial Board Member, Saudi Pharmaceutical Journal Teaching Experience: Courses Taught at King Saud University, College of Pharmacy:
A. Undergraduate Level:
PHT 252: Dispersion Systems and Drug Stability PHT 312: Pharmaceutics II PHT 351: Sterile Dosage Forms PHT 453: Hospital Pharmacy II: Operational Services PHT 463: Quality Control of Pharmaceutical Dosage Forms Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Teaching Experience (continued):
PHT 591: Seminar PHT 540: Drug Delivery Systems Courses Taught at Riyadh College of Dentistry and Pharmacy: PHRM 321: Pharmaceutics -1- PHRM 324: Pharmaceutical Biotechnology Areas of Research Interest:
Pharmaceutical Technology Pharmaceutical Biotechnology Drug Delivery Controlled Drug Release
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Current Ongoing and Funded Projects:
2009 – 2010 Human Carrier Erythrocytes as A Targeted Delivery of Primaquine: Biochemical Hematological Evaluation, Center of Excellence in Biotechnology Research, Center of Excellence Programs, King Saud University, Ministry of Higher Education, (CEBROF-1430/2), SR 100,000. Improvement Enhanced Production Clavulanic Acid in KSA Using Olive Oil as a Sole Carbon Source, Center of Excellence in Biotechnology Research, Center of Excellence Programs, King Saud University, Ministry of Higher Education, (CEBROF- 1430/4), SR 100,000. Design and Synthesis of a Novel Crown Ether- Crosslinked Chitosan for Removal of Toxic Metal Ions (M+n) Wastewater: Industrial Application. Center of Excellence for Research in Engineering Materials, Center of Excellence Programs, King Saud University, Ministry of Higher Education, (03-CEREM-430), SR 150,000. Improvement of the Oral Bioavailability of Celecoxib by Spray Drying Technique, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 251), SR 25,200. Optimization Nanoemulsion Nanoemulsifying Drug Delivery Systems for Oral Drug Delivery. NANO Program, Strategic Plan for Technology and Sciences Program, National Plan for Sciences and Technology Program, Ministry of Higher Education, King Saud University, (08-NAN307-2), SR 9 Production and Site-specific Delivery of Belomycin for Treatment of Cancer, Center of Excellence in Biotechnology Research, Center of Excellence Programs, King Saud University, Ministry of Higher Education, (CEBR6), SR 4,385,000. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Current Ongoing and Funded Projects (continued): 2008 – 2009 Development and In vitro Evaluation of Proniosomes as a Transdermal Delivery System for Piroxicam, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 219), SR 35,000. The Development of New Drug Delivery System for Diagnosis and Treatment of Colon Cancer, King Abdulaziz City for Science and Technology, General Directorate of Research and Grants Program, (APR-25- 023), SR 880,268. A new Extended Release Delivery System of Verapamil Gastroretentive Chitosan Microparticles, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 143), SR 43,031. Erythrocytes: A novel Drug Delivery System to Target Anticancer Agent to Liver Cancer, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 144), SR 40,000. Hydrophilic Polymers Macromolecules on the Properties of Prolonged Release Chitosan Microparticles: In vitro and In vivo Evaluation, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 145), SR 42,500. Analgesic Efficacy of Ketorolac as a Local Buccal Drug Delivery System: Clinical Trial, College of Dentistry Research Center (CDRC), College of Dentistry and College of Pharmacy Research Center (CPRC), King Saud University, (C.P.R.C. 169). Effects of Gamma Radiation on Drug Metabolism and the Release Characteristics of Drugs from Different Dosage Forms, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 128), SR 25,000. Enhancement of Propranolol Penetration through Skin Using Niosomes, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 131), SR 12,000. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Current Ongoing and Funded Projects (continued):
2004 – 2006 Effect of Gamma Sterilization on the Properties of Ophthalmic Preparations: In vitro and In vivo Study, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 126), SR 12,000. Effect of Cyclodextrins on the Chemical Stability of Some Commonly Used Antibiotics, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 130), SR 12,000. Improvement of Atenolol Bioavailability Using Niosomes as Drug Carrier, Research Center, College of Pharmacy, King Saud University, (C.P.R.C.129), SR 12,000. Preparation of Rifampicin Microspheres as Targeting Delivery System, College of Pharmacy, King Saud University, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 99), SR 20,000. Evaluation of Crosslinked Hydrogel Beads as a Carrier for Prolonged Delivery of Pharmaceuticals, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 104), SR 16,758. Proniosomes Transdermal Delivery, Research Center, College of Pharmacy, King Saud University, (C.P.R.C. 103), SR 15,000. Patents: 1. Title: “Novel Buccoadhesive Films Containing Ketorolac for Post-oral Surgery Pain
Management”. Submitted: to the General Directorate of Patents, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia. Application Number: 07280357 Date of Submission: 1/7/2007 Status: Pending approval. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Patents (continued): 2. Title: “Aspirin-Caffeine Complex for Rectal Administration” Submitted: to the General Directorate of Patents, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia and Intellectual Property Program, Vice Rectorate for Knowledge Exchange and Technology Transfer, King Saud University, Riyadh, Saudi Arabia. Application Number: 109300098 Date of Submission: 8/2/2009 Status: Pending approval.
3. Title: “Saudi-Corn Starch for Preparation of Highly Efficient Immediate Release
Tablets” Submitted: to the General Directorate of Patents, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia and Intellectual Property Program, Vice Rectorate for Knowledge Exchange and Technology Transfer, King Saud University, Riyadh, Saudi Arabia. Application Number: 109300198 Date of Submission: 25/3/2009 Status: Pending approval. 4. Title: “Utilization of Locally Produced Date Syrup from Kingdom's Date as a Tablet
Binder” Submitted: to the General Directorate of Patents, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia and Intellectual Property Program, Vice Rectorate for Knowledge Exchange and Technology Transfer, King Saud University, Riyadh, Saudi Arabia. Application Number: 109300197 Date of Submission: 25/3/2009 Status: Pending approval. 5. Title: “Aspirin glutamic acid complex for oral administrationder” Submitted: to the General Directorate of Patents, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia and Intellectual Property Program, Vice Rectorate for Knowledge Exchange and Technology Transfer, King Saud University, Riyadh, Saudi Arabia. Application Number: 109300287 Date of Submission: 11/5/2009 Status: Pending approval. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Current Graduate Students in Training:
1. Mr. Zayed M. Aloshban, M.S. Student; Co-advisor and Member of the Supervisory Research Title: “Preparation of Sustained Release Dextromethorphan Microparticles Using the Spray Drying Technique”. Past Graduate Students:
Ms. Iman Mohammed Rashed Al-Fagih, M.S. Student; Co-advisor and Member of the Supervisory Committee. Research Title: “Transdermal Delivery System of Testosterone Using Solid Lipid Microparticles”.
Ms. Lubna Yousef Mohamed Ashri, M.S. Student; Co-advisor and Member of the Supervisory Committee. Research Title: “Metronidazole Buccoadhesive Film for the Treatment of Periodontal Disease”.
Ms. Amel Y. Hamed, M.S. Student; Major advisor and Member of the Supervisory Committee. Research Title: “Development and Evaluation of Liposomal Mucoadhesive Gels for Nasal Delivery of Acyclovir”.
Ms. Foza Kayem AL-Enazy, M.S. Student; Member of the Supervisory and Examination Committee. Research Title: “Polymers Blends and their Effects on the Mechanical Behavior and Physical Properties of Prolonged Release Tablets Prepared by Direct Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications:
A)- Book Chapters:
1. Ibrahim A. Alsarra, M. Al-Omar and F. Belal. Valproic acid and sodium valproate:
comprehensive profile. In: Harry G. Brittain, editor. Profiles of Drug, Substances, Excipients and Related Methodology. Academics Press: New York, USA; Volume 32, 209-240 (2005).
2. Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, and Gamal M. El Maghraby
Vesicular systems for intranasal drug delivery. In: Kewal K. Jain, editor. Drug Delivery to the Central Nervous System. Humana Press, Inc.: Totowa, NJ, USA, (In Press).
Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications (continued):
A)-Peer-reviewed Articles: 1.
Mahmoud EL-Badry, Fars K. Alanazi, Gamal M. Mahrous and Ibrahim A. Alsarra. Effects of Kollicoat IR® and Hydroxypropyl-β Cyclodextrin on the Dissolution Rate of Omeprazole from its Microparticles and Enteric-coated Capsules. Pharmaceutical Development and Technology.(2009 Oct 8.) [Epub ahead of print]).
Ehab A. Fouad, Mahmoud EL-Badry, Fars K. Alanazi, Maha M. Arafah, Riyadh Al-Ashban, and Ibrahim A. Alsarra. Preparation and Investigation of Aspirin- Caffeine Complex for Rectal Administration. Pharmaceutical Development and Technology.(2009 Jul 30) [Epub ahead of print].
Ibrahim A. Alsarra, Amel Y. Hamed, Fars K. Alanazi, and Gamal M. El Maghraby Vesicular Systems for Intranasal Drug Delivery. In: Kewal K. Jain, editor. Drug Delivery to the Central Nervous System. Humana Press, Inc.: Totowa, NJ, USA, (In Press).
Alaa Eldeen Bakry Yassin, Ibrahim A. Alsarra, Fars K. Alanazi, Abdullah M. Al-Mohizea,
Targeted-colon Delivery System: in vitro and in vivo Evaluation using X-ray Imaging. Journal of Drug Targeting.18 (1), 59-66 (2010). Ibrahim A. Alsarra. High Performance Liquid Chromatographic Method for Quantitative Determination of Amlodipine in Human Plasma and Pharmaceutical Dosage Form and Its Application to Pharmacokinetic Studies. Journal of Chromatographic Science.47 (10), 863-867 (2009).
Mahmoud El-Badry, Ehab I. Taha, Fars K. Alanazi and Ibrahim A. Alsarra. Study of omeprazole stability in aqueous solution: influence of cyclodextrins. Journal of Drug Delivery Science and Technology.19 (5), 347-351 (2009). 7.
Fars K. Alanazi, Alaa Eldeen Yassin, Mahmoud El-Badry, Hammam A. Mowafy and Ibrahim A. Alsarra. Validated High Performance Liquid Chromatographic Technique for Determination of 5-Fluorouracil: Applications to Stability Studies and Simulated Colonic Media. Journal of Chromatographic Science.47 (7), 558- 563 (2009). Ibrahim A. Alsarra. Evaluation of Proniosomes as an Alternative Strategy to Optimize Piroxicam Transdermal Delivery. Journal of Microencapsulation.26 (3), 272-278 (2009). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications (continued):
9. Ibrahim A. Alsarra. Chitosan Topical Gel Formulation in the Management of Burn Wounds. International Journal of Biological Macromolecules.45 (1), 16-21 (2009).
Ehab A. Fouad, Mahmoud El-Badry, Fars K. Alanazi, Maha M. Arafah, and Ibrahim A. Alsarra. Preparation and Investigation of Acetyl Salicylic Acid Glutamic Acid Complex: a Novel Oral Delivery System. Digest Journal of Nanomaterials and Biostructures. 4 (2), 299-308 (2009).
Gamal M. El Maghraby, Fars K. Alanazi and Ibrahim A. Alsarra. Transdermal Delivery of Tadalafil. I. Effect of Vehicles on Skin Permeation. Drug Development and Industrial Pharmacy.35 (3), 329-336 (2009). Ibrahim A. Alsarra, Amal Y. Hamed, Gamal M. Mahrous, Gamal M. El Maghraby, Abdulrahman A. Al-Robayan and Fars K. Alanazi. Mucoadhesive polymeric hydrogels for nasal delivery of acyclovir. Drug Development and Industrial Pharmacy.35 (3), 352-362 (2009).
Alaa Eldeen B. Yassin, Fars K. Alanzi, Mahmoud El-Badry, Ibrahim A. Alsarra and Nahla S. Barakat. Preparation and Characterization of Spironolactone-loaded Gelucire Microparticles Using Spray Drying Technique. Drug Development and Industrial Pharmacy. 35 (3), 297-304 (2009). Ibrahim A. Alsarra, Amal Y. Hamed and Fars K. Alanazi. Acyclovir Liposomes for Intranasal Systemic Delivery: Development and Pharmacokinetics Evaluation. Drug Delivery. 15 (5), 313-321 (2008).
Fars K. Alanazi, Ibrahim M. El-Bagory, Ibrahim A. Alsarra, Mostfa Abdulgaoy and Mohsen A. Byomi. Saudi-Cultivated Corn Starch as Tablets Excipient Compared with Imported Starch. Saudi Pharmaceutical Journal. 16 (2), 112-121 (2008).
Amal El-Kamel, Iman M. Al-Fagih and Ibrahim A. Alsarra. Effect of Sonophoresis and Chemical Enhancers on Testosterone Transdermal Delivery from Solid Lipid Microparticles: An In Vitro Study. Current Drug Delivery. 5 (1), 20-26 (2008).
Fars K. Alanazi, Sayed M. Ahmed, Suliman S. Alhamed, Hammam. A. Mowafy, Ibrahim A. Alsarra and Mohsen A. Bayomi. Inclusion Complexation of Itraconazole
Physicochemical Characterization. Mansoura Journal of Pharmaceutical Sciences. 23 (2), 177-194 (2007). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications (continued):
18. Ibrahim A. Alsarra, Fars K. Alanazi, Jamal M. Mahrous, Aly A. Abdel Rahman and Khalid Al Hezaimi. Clinical Evaluation of Buccoadhesive Film Containing Ketorolac in Dental and Post-Oral Pain Management. Pharmazie. 62 (10), 773- 778 (2007).
Amal Hassan El-Kamel, Lubna Y. Ashri and Ibrahim A. Alsarra. Micromatricial Metronidazole Benzoate Film as a Local Mucoadhesive Delivery System for Treatment of Periodontal Diseases. AAPS PharmSciTech. 8 (3), E1-E11 (2007). Article 75 (http://www.aapspharmscitech.org/articles/pt0803/pt0803075/pt0803075.pdf). Ibrahim A. Alsarra, Mahrous O. Ahmed, Mahmoud El-Badry, Fars K. Alanazi, Abdullah M. Al-Mohizea and Sayed M. Ahmed. Effect of β-cyclodextrin Derivatives on the Kinetics of Degradation of Cefotaxime Sodium in Solution State. Journal of Drug Delivery Science and Technology. 17 (5), 353-357 (2007).
Fars K. Alanazi, Mahmoud El-Badry, Mahrous O. Ahmed, and Ibrahim A. Alsarra. Improvement of Albendazole Dissolution by Preparing Microparticles Using Spray-Drying Technique. Scientia Pharmaceutica. 75, 63-79 (2007).
Abdullah M. Al-Mohizea, Ibrahim M. El-Bagory, Ibrahim A. Alsarra, Fahad I. Al-Jenoobi and Mohsen A. Bayomi. Effect of Gamma Radiation on the Physicochemical Properties of Ciprofloxacin in Solid State. Journal of Drug Delivery Science and Technology. 17 (3), 211-215 (2007).
Fars K. Alanazi, Aly A. Abdel Rahman, Jamal M. Mahrous and Ibrahim A. Alsarra. Formulation and Physicochemical Characterization of Buccoadhesive Films Containing Ketorolac. Journal of Drug Delivery Science and Technology. 17 (3), 183-192 (2007).
Amal El-Kamel, Iman M. Al-Fagih and Ibrahim A. Alsarra. Testosterone Solid Lipid Microparticles for Transdermal Drug Delivery. Formulation and Physicochemical Characterization. Journal of Microencapsulation. 24 (5), 457- 475 (2007). Ibrahim A. Alsarra, Fars K. Alanazi, Suliman S. Alhamed, Sayed M. Ahmed and Hamam. A. Mowafy. Preparation and Evaluation of Itraconazole- Cyclodextrin Complexes in Solid State. Alexandria Journal of Pharmaceutical Sciences. 21 (1), 47-55 (2007).
Alaa Eldeen B. Yassin, Ibrahim A. Alsarra and Abdullah M. Al-Mohizea. Chitosan Beads as a New Gastroretentive System of Verapamil. Scientia Pharmaceutica. 74, 175-188 (2006). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications (continued):
27. Ibrahim A. Alsarra, William G. Brockmann, Michael L. Cunningham and Mostafa Z. Badr. Hepatocellular Proliferation in Response to Agonists of Peroxisome Proliferator-Activated Receptor Alpha: A Role for Kupffer Cells? Journal
(http://www.carcinogenesis.com/content/pdf/1477-3163-5-26.pdf).
Fars K. Alanazi, Mahmoud El-Badry and Ibrahim A. Alsarra. Spray-Dried HPMC Microparticles of Indomethacin: Impact of Drug-Polymer Ratio and Viscosity of the Polymeric Solution on Dissolution. Saudi Pharmaceutical Journal. 14 (2), 99-106 (2006). Ibrahim A. Alsarra, M. Al-Omar and F. Belal. Valproic Acid and Sodium Valproate: Comprehensive Profile. Profiles of Drug, Substances, Excipients and Related Methodology, Harry G. Brittain (editor), Academics Press, New York. Volume 32, 209-240 (2005). Ibrahim A. Alsarra, N.Y. Khalil, M. Sultan, R. Al-Ashban, and F. Belal. Spectrofluorimetric Determination of Montelukast in Dosage Forms and Spiked Human Plasma. Pharmazie. 60 (11), 823-826 (2005). Ibrahim A. Alsarra, Ahmed A. Bosela, Abdullah M. Al-Mohizea, Jamal M. Mahrous, and Steven H. Neau. Modulating Intestinal Uptake of Atenolol Using Niosomes as Drug Permeation Enhancers. Scientia Pharmaceutica. 73 (3), 81-93 (2005).
Yousif A. Asiri, Mansour S. Al-Said, Khalil I. Al-Khamis, Esmail M. Niazy, Yousry M. El-Sayed, Khalid A. Al-Rashood, Mohammed J. Al-Yamani, Ibrahim A. Alsarra, and Suliman A. Al-Balla. Comparative Bioavailability Study of Cefixime (Equivalent to 100 mg/5 ml) Suspension Winex vs Suprax for Bioequivalence Evaluation in Healthy Adult Volunteers. International Journal of Clinical Pharmacology and Therapeutics. 43 (10), 499-504 (2005). Ibrahim A. Alsarra, Ibrahim Mustafa El-Bagory, and Mohsen A. Bayomi. Chitosan and Sodium Sulfate as Excipients in the Preparation of Prolonged Release Theophylline Tablets. Drug Development and Industrial Pharmacy. 31 (4), 385-395 (2005). Ibrahim A. Alsarra, M. Al-Omar, R. Gadkariem, and F. Belal. Voltammetric Determination of Montelukast Sodium in Dosage Forms and Human Plasma. IL Farmaco. 60 (6-7), 563-567 (2005). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications (continued):
35. Ibrahim A. Alsarra, Esmail M. Niazy, Yousry M. El-Sayed, Khalil I. Al- Khamis, and Mahmoud El-Awad Ibrahim. High Performance Liquid Chromatographic Assay Method for Determination of Doxycycline in Human Plasma and its Application in Pharmacokinetic Studies. Saudi Pharmaceutical Journal. 13 (1), 42-47 (2005). Ibrahim A. Alsarra, Ahmed A. Bosela, Sayed M. Ahmed, and Jamal Mahrous. Proniosomes as a Drug Carrier for Transdermal Delivery of Ketorolac. European Journal of Pharmaceutics and Biopharmaceutics. 59 (3), 485-490 (2005). Ibrahim A. Alsarra. Evaluation of Crosslinked Hydrogel Beads as a Carrier for Prolonged Delivery of Diclofenac Sodium: In Vitro and In Vivo Studies. Bolletino Chimico Farmaceutico. 143 (10), 359-364 (2005). Ibrahim A. Alsarra. Development of a Stability-indicating HPLC Method for Quantitative Determination of Montelukast in Tablets and Human Plasma and Its Applications to Pharmacokinetic and Stability Studies. Saudi Pharmaceutical Journal. 12 (4), 136-143 (2004).
Mohammed A. Al-Omar, Christine Beedham and Ibrahim A. Alsarra. Pathological Roles of Reactive Oxygen Species and their Defense Mechanisms. Saudi Pharmaceutical Journal. 12 (1), 1-18 (2004). Ibrahim A. Alsarra, Mansour S. Al-Said, Khalil I. Al-Khamis, Esmail M. Niazy, Yousry M. El-Sayed, Khalid A. Al-Rashood, Mohammed J. Al-Yamani, and Suliman A. Al-Balla. Comparative Bioavailability Study of Doxycycline Hyclate (Equivalent to 100 mg Doxycycline) Capsules (Doxycin Vs Vibramycin) for Bioequivalence Evaluation in Healthy Adult Volunteers. International Journal of Clinical Pharmacology and Therapeutics. 42 (7), 373-377 (2004). Ibrahim A. Alsarra and Mohammed N. Alarifi. Validated Liquid Chromatographic Determination of 5-fluorouracil in Human plasma. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences. 804 (2), 435-439 (2004). Ibrahim A. Alsarra, Steven H. Neau, and Matthew A. Howard. Effects of Preparative Parameters on the Properties of Chitosan Hydrogel Beads Containing Candida Rugosa Lipase. Biomaterials. 25 (13), 2645-2655 (2004). Ibrahim A. Alsarra. “Pharmaceutics, The Science of Dosage Form Design, Second Edition”, A book review. Saudi Pharmaceutical Journal. 11 (4), 206-207 (2003). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Publications (continued): 44. Ibrahim A. Alsarra, Seema S. Betigeri, Hua Zhang, Barry Evans, and Steven H. Neau. Molecular Weight and Degree of Deacetylation Effects on Lipase-Loaded Chitosan Beads Characteristics. Biomaterials. 23 (17), 3637-3644 (2002).
Hua Zhang, Ibrahim A. Alsarra, and Steven H. Neau. An In Vitro Evaluation of a Chitosan-Containing Multiparticulate System for Macromolecule Delivery to the Colon. International Journal of Pharmaceutics. 239 (1-2), 197-205 (2002). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Ibrahim A. Alsarra, Amal Y. Hamed and Fars K. Alanazi. Acyclovir Liposomes for Intranasal Systemic Delivery: Development and Pharmacokinetics Evaluation. Presented at Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT 2010), Dubai International Convention & Exhibition Centre, Dubai, United Arab Emirates, 15-17 March, 2010. Ibrahim A. Alsarra, Amal Y. Hamed and Fars K. Alanazi. Acyclovir Liposomes for Intranasal Systemic Delivery: Development and Pharmacokinetics Evaluation. Presented at The Second International Conference on Drug Discovery & Therapy, Dubai, United Arab Emirates, 1-4, February, 2010.
Magdi M. Abdel-Hamid, Alaa Eldeen B. Yassin, Ibrahim A. Alsarra and Fars K. Alanazi.
Spectrometric Method for Determination of 5-Aminolevulinic Acid in Oral Colonic Targeted Tablets for Diagnosis of Colon Cancer. Presented at the 69th International Congress of FIP, FIP World Congress of Pharmacy and Pharmaceutical Sciences, Istanbul Lütfi Kırdar Congress and Exhibition Center, Harbiye 34267, Istanbul, Turkey, 3-8/9/2009.
Magdi M. Abdel-Hamid, Ibrahim A. Alsarra and Fars K. Alanazi. UPLC/MS/MS Method for Simultaneous Determination of Chloroquine Phosphate, Quinine Sulfate and Primaquine Diphosphate in Human Plasma. Presented at the 69th International Congress of FIP, FIP World Congress of Pharmacy and Pharmaceutical Sciences, Istanbul Lütfi Kırdar Congress and Exhibition Center, Harbiye 34267, Istanbul, Turkey, 3-8/9/2009.
Mohsen A. Bayomi, Ibrahim A. Alsarra, Ibrahim M. El-Bagory and Gammal M. Mahrous. Effect of Gamma Irradiation on Ciprofloxacin Pluronic Gels for Ocular Delivery: In Vitro Study. Presented at the 14th International Symposium on Recent Advances in Drug Delivery Systems: "Drug Carriers: Beyond Delivery", Salt Lake City, UA, USA, 15-18/2/2009.
Alaa Eldeen B. Yassin, Fars K. Alanzi, Mahmoud El-Badry, Ibrahim A. Alsarra and Nahla S. Barakat. Preparation and Characterization of Spironolactone-loaded Gelucire Microparticles Using Spray Drying Technique. Presented at American Association of Pharmaceutical Scientists Annual Meeting, Nashville, Atlanta, GA, USA, 2008. AAPS Pharmaceutical Sciences 10(52), (2008). Ibrahim A. Alsarra, Amal Y. Hamed and Fars K. Alanazi. Acyclovir Liposomes for Intranasal Systemic Delivery: Development and Pharmacokinetics Evaluation. Presented at American Association of Pharmaceutical Scientists Annual Meeting, Nashville, Atlanta, GA, USA, 2008. AAPS Pharmaceutical Sciences 10(52), (2008). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Abstracts (continued): A8. Ibrahim A. Alsarra, Ahmed A. Bosela, Sayed M. Ahmed, and Jamal Mahrous. Proniosomes as a Drug Carrier for Transdermal Delivery of Ketorolac. Presented at the Nanostructured Advanced Materials Workshop, A co-joined program organized University of Jordan in Amman, Jordan and National Science Foundation, Washington, DC, USA, November 10-13, 2009. Ibrahim A. Alsarra, Fars K. Alanazi, Jamal M. Mahrous, Aly A. Abdel Rahman and Khalid Al Hezaimi. Clinical Evaluation of Buccoadhesive Film Containing Ketorolac in Dental and Post-Oral Pain Management. Presented at The American Association of Pharmaceutical Science National Biotechnology, San Diego, California, USA, 2007.
A10. Alaa El-deen B. Yassin, Ibrahim A. Alsarra and Abdullah Al-Mohizea. Chitosan
Beads as a New Gastroretentive System of Verapamil. Presented at The 3rd World Congress of the Board of Pharmaceutical Sciences of FIP (PSWC2007): Optimizing Drug Therapy: An Imperative for World Health, RAI Congress Centre, Amsterdam, The Netherlands, 2007.
A11. Fars K. Alanazi, Gamal El Maghraby and Ibrahim A. Alsarra. A Stability
Indicating High-performance Liquid Chromatographic Method for Determination of Tadalafil. Presented at The 7th International Saudi Pharmaceutical: Pharmacy Climbing A New Heights, Saudi Pharmaceutical Society, Riyadh, Saudi Arabia, 2007.
A12. Amal H. El-Kamel, Ibrahim A. Alsarra and Iman M. Al-Faqih. Transdermal
Delivery System of Testosterone Using Solid Lipid Particles. Presented at The 9th International Pharmaceutical Sciences Conference and Exposition. Organized by College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 2005.
A13. Ibrahim M. El-Bagory, Ibrahim A. Alsarra, Fahad I. Al-Janoobi, Abdullah M.
Al-Mohizea and Mohsen A. Bayomi. Effect of Gamma Radiation on Physicochemical Properties of Ciprofloxacin Solid State. Presented at The 9th International Pharmaceutical Sciences Conference and Exposition. Organized by College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 2005.
A14. Amal H. El-Kamel, Ibrahim A. Alsarra and Lubna Y. Ashri. Metronisazole
Buccoadhesive Film for the Treatment of Periodontal Diseases. Presented at The 9th International Pharmaceutical Sciences Conference and Exposition. Organized by College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 2005.
A15. Ibrahim A. Alsarra, Ibrahim Mustafa El-Bagory, Jamal M. Mahrous and
Mohsen A. Bayomi. Effects of Gamma Irradiation of the Properties of Ciprofloxacin Ophthalmic Gels. Presented at the American Association of Pharmaceutical Scientists, 20th Annual Meeting, Nashville, TN, USA, 2005. Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Abstracts (continued):
A16. Fars K. Alanazi, Ibrahim A. Alsarra and Mhamoud El-Badry. Spray-dried
Microparticles of Indomethacin: Impact of Drug-polymer Ratio and Viscosity of the Polymeric Solution to Enhance Dissolution Rate. Presented at the American Association of Pharmaceutical Scientists, 20th Annual Meeting, Nashville, TN, USA, 2005.
A17. Alaa El-deen B. Yassin, Ibrahim A. Alsarra and Abdullah Al-Mohizea. Chitosan
Beads as a New Gastroretentive System of Verapamil. Presented at the Pharmacy: A profession in Transition, Organized by King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, 2005.
A18. Ibrahim A. Alsarra, Ahmed A. Bosela, Abdullah M. Al-Mohizea, and Steven H.
Neau. Modulating Intestinal Uptake of Atenolol Using Niosomes as Drug Permeation Enhancers. Presented at the 3rd World Conference on Drug Absorption, Transport and Delivery: Clinical Significance and Regulatory Impact, Organized by the European Federation for Pharmaceutical Sciences, Barcelona, Spain, 2005.
A19. Niosomes as a Novel Drug Carrier for Transdermal Delivery. Ibrahim A. Alsarra, Ahmed A. Bosela, Sayed M. Ahmed, and Jamal Mahrous. Presented at the 6th Saudi Pharmaceutical International Conference, Riyadh, Saudi Arabia, 2003.
A20. Chitosan Sodium Sulfate Interaction for the Preparation of Prolonged Release
Theophylline Tablets Using Wet Granulation Method. Ibrahim A. Alsarra, Mohsen A. Bayomi, Ibrahim Mustafa El-Bagory. Presented at the American Association of Pharmaceutical Scientists, 18th Annual Meeting, Salt Lake City, UT, USA, 2003. AAPS Pharmaceutical Sciences 5(4), (2003).
A21. Effects of Preparative Parameters on the Properties of Chitosan Hydrogel Beads
Containing Candida Rugosa Lipase. Steven H. Neau and Ibrahim A. Alsarra. Presented at the American Association of Pharmaceutical Scientists, 17th Annual Meeting, Toronto, Ontario, Canada, 2002.
A22. Hierarchical regression analysis of molecular weight and degree of deacetylation
effects on lipase-loaded chitosan hydrogel beads. Ibrahim A. Alsarra and Steven H. Neau. Presented at the American Association of Pharmaceutical Scientists, 16th Annual Meeting, Denver, CO, USA, 2001. AAPS Pharmaceutical Sciences3(3), (2001). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010) Abstracts (continued):
A23. Lipase-loaded chitosan hydrogel beads II: effects of pH and counterion
concentration in the gelling medium. Ibrahim A. Alsarra and Steven H. Neau. Presented at the American Association of Pharmaceutical Scientists, 15th Annual Meeting, Indianapolis, IN, USA, 2000. AAPS Pharmaceutical Sciences2(4), (2000).
A24. The effects of processing conditions and chitosan physicochemical properties on
lipase-loaded bead characteristics. Ibrahim A. Alsarra and Steven H. Neau. Presented at the 3rd International symposium on Chitin Enzymology and 4th Conference of the European Chitin Society. Ancona, Italy, 2000. Chitin Society Bulletin.
A25. Molecular weight and degree of deacetylation effects on lipase-loaded chitosan
beads characteristics. Ibrahim A. Alsarra, Seema S. Betigeri, Hua Zhang, and Steven H. Neau. Presented at the American Association of Pharmaceutical Scientists, 14th Annual Meeting, New Orleans, LA, USA, 1999. AAPS Pharmaceutical Sciences1(4), (1999).
A26. Molecular weight and degree of deacetylation effects on lipase-loaded chitosan
beads characteristics. Ibrahim A. Alsarra, Seema S. Betigeri, Hua Zhang, and Steven H. Neau. Presented at the Pharmaceutical Sciences Graduate Research, 31st Annual Meeting, held at the University of Missouri-Kansas City, MO, USA, 1999.
A27. Mechanism of transport of leutinizing hormone releasing hormone across lung
epithelial airways. Ibrahim A. Alsarra, T.P. Johnston and A.K. Mitra. Presented at the American Association of Pharmaceutical Scientists, 13th Annual Meeting, San Francisco, CA, USA, 1998. AAPS Pharmaceutical Sciences1(1), (1998). Curriculum Vitae of Professor Ibrahim A. Alsarra (2010)
CASE STUDIES CASE STUDY 2 Background THE ADVANCE STUDY (ACTION IN DIABETES AND VASCULAR DISEASE: PRETERAX AND DIAMICRON MR CONTROLLED EVALUATION) A study called ADVANCE will provide new evidence about widely practical treatment strategies for the prevention of the vascular complications of diabetes. It will determine the effects of intensive blood pressure lowering and glu