Rtk hsfs 0832

ESTRADIOL
--------------------------------------------------------------------------- --------------------------------------------------------------------------- HAZARD SUMMARY
WORKPLACE EXPOSURE LIMITS
Estradiol can affect you when breathed in and by passing
No occupational exposure limits have been established for Estradiol. This does not mean that this substance is not
Contact can irritate the skin and eyes.
harmful. Safe work practices should always be followed.
High exposure to Estradiol can cause headache, nausea
and vomiting.
It should be recognized that Estradiol can be absorbed
Repeated exposure can cause swelling and cramps of the through your skin, thereby increasing your exposure.
legs, and enlarged and painful breasts in men and women.
Estradiol may affect the liver.
WAYS OF REDUCING EXPOSURE
*
Where possible, enclose operations and use local exhaust IDENTIFICATION
ventilation at the site of chemical release. If local exhaust Estradiol is an odorless, white to yellowish powder. It is used
ventilation or enclosure is not used, respirators should be REASON FOR CITATION
Wash thoroughly immediately after exposure to Estradiol
Estradiol is on the Hazardous Substance List because it is
Post hazard and warning information in the work area. In addition, as part of an ongoing education and trainingeffort, communicate all information on the health and safety HOW TO DETERMINE IF YOU ARE BEING
hazards of Estradiol to potentially exposed workers.
The FDA (Food and Drug Administration) has setstandards for Good Manufacturing Practices for Drugs and The New Jersey Right to Know Act requires most employers to Pharmaceuticals. These should be followed for your label chemicals in the workplace and requires public employers protection as well as product quality. See the FDA to provide their employees with information and training concerning chemical hazards and controls. The federal OSHAHazard Communication Standard, 1910.1200, requires privateemployers to provide similar training and information to theiremployees.
Exposure to hazardous substances should be routinelyevaluated. This may include collecting personal and area airsamples. You can obtain copies of sampling results fromyour employer. You have a legal right to this informationunder OSHA 1910.1020.
If you think you are experiencing any work-related healthproblems, see a doctor trained to recognize occupationaldiseases. Take this Fact Sheet with you.
ESTRADIOL
This Fact Sheet is a summary source of information of all Request copies of your medical testing. You have a legal right potential and most severe health hazards that may result from to this information under OSHA 1910.1020.
exposure. Duration of exposure, concentration of the substanceand other factors will affect your susceptibility to any of the Mixed Exposures
Because more than light alcohol consumption can cause ----------------------------------------------------------------------------- liver damage, drinking alcohol may increase the liver damage
caused by Estradiol.
HEALTH HAZARD INFORMATION
WORKPLACE CONTROLS AND PRACTICES
Acute Health Effects
The following acute (short-term) health effects may occur
Unless a less toxic chemical can be substituted for a hazardous immediately or shortly after exposure to Estradiol:
substance, ENGINEERING CONTROLS are the most effective
way of reducing exposure. The best protection is to enclose
Contact can irritate the skin and eyes.
operations and/or provide local exhaust ventilation at the site ofchemical release. Isolating operations can also reduce exposure.
Chronic Health Effects
Using respirators or protective equipment is less effective than The following chronic (long-term) health effects can occur at the controls mentioned above, but is sometimes necessary.
some time after exposure to Estradiol and can last for months or
years:
In evaluating the controls present in your workplace, consider:(1) how hazardous the substance is, (2) how much of the Cancer Hazard
substance is released into the workplace and (3) whether While Estradiol has not been identified as a carcinogen, it
harmful skin or eye contact could occur. Special controls should be HANDLED WITH CAUTION since several should be in place for highly toxic chemicals or when significant related Estrogens are human carcinogens.
skin, eye, or breathing exposures are possible.
Many scientists believe there is no safe level of exposure toa carcinogen. Such substances may also have the potential In addition, the following control is recommended: for causing reproductive damage in humans.
Where possible, automatically transfer Estradiol from drums
Reproductive Hazard
or other storage containers to process containers.
According to the information presently available to the New
Jersey Department of Health and Senior Services, Estradiol
Good WORK PRACTICES can help to reduce hazardous
has not been tested for its ability to affect reproduction.
exposures. The following work practices are recommended: Other Long-Term Effects
Workers whose clothing has been contaminated by High exposure to Estradiol can cause headache, nausea and
Estradiol should change into clean clothing promptly.
Do not take contaminated work clothes home. Family Repeated exposure can cause swelling and cramps of the legs, enlarged and painful breasts in men and women, breast Contaminated work clothes should be laundered by lumps, discharge from the nipples, and weight gain.
individuals who have been informed of the hazards of Estradiol may affect the liver.
exposure to Estradiol.
Eye wash fountains should be provided in the immediate If there is the possibility of skin exposure, emergencyshower facilities should be provided.
Medical Testing
On skin contact with Estradiol, immediately wash or shower
If symptoms develop or overexposure is suspected, the to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Estradiol,
whether or not known skin contact has occurred.
Do not eat, smoke, or drink where Estradiol is handled,
processed, or stored, since the chemical can be swallowed.
Any evaluation should include a careful history of past and Wash hands carefully before eating, drinking, applying present symptoms with an exam. Medical tests that look for cosmetics, smoking, or using the toilet.
damage already done are not a substitute for controlling Use a vacuum or a wet method to reduce dust during clean- ESTRADIOL
PERSONAL PROTECTIVE EQUIPMENT
Be sure to consider all potential exposures in yourworkplace. You may need a combination of filters, prefilters WORKPLACE CONTROLS ARE BETTER THAN PERSONAL or cartridges to protect against different forms of a chemical PROTECTIVE EQUIPMENT. However, for some jobs (such as (such as vapor and mist) or against a mixture of chemicals.
outside work, confined space entry, jobs done only once in a Where the potential for high exp osure exists, use a NIOSH while, or jobs done while workplace controls are being approved supplied-air respirator with a full facepiece installed), personal protective equipment may be appropriate.
operated in a pressure-demand or other positive-pressuremode. For increased protection use in combination with an OSHA 1910.132 requires employers to determine the appropriate auxiliary self-contained breathing apparatus operated in a personal protective equipment for each hazard and to train pressure-demand or other positive-pressure mode.
employees on how and when to use protective equipment.
QUESTIONS AND ANSWERS
The following recommendations are only guidelines and maynot apply to every situation.
If I have acute health effects, will I later get chronic healtheffects? Clothing
Not always. Most chronic (long-term) effects result from Avoid skin contact with Estradiol. Wear protective gloves
and clothing. Safety equipment suppliers/manufacturers canprovide recommendations on the most protective Can I get long-term effects without ever having short-term glove/clothing material for your operation.
All protective clothing (suits, gloves, footwear, headgear) Yes, because long-term effects can occur from repeated should be clean, available each day, and put on before work.
exposures to a chemical at levels not high enough to makeyou immediately sick.
Eye Protection
What are my chances of getting sick when I have been Wear eye protection with side shields or goggles.
Wear a face shield along with goggles when working with The likelihood of becoming sick from chemicals is corrosive, highly irritating or toxic substances.
increased as the amount of exposure increases. This isdetermined by the length of time and the amount of Respiratory Protection
material to which someone is exposed.
IMPROPER USE OF RESPIRATORS IS DANGEROUS. Such
equipment should only be used if the employer has a written
program that takes into account workplace conditions, Conditions which increase risk of exposure include dust requirements for worker training, respirator fit testing and releasing operations (grinding, mixing, blasting, dumping, medical exams, as described in OSHA 1910.134.
etc.), other physical and mechanical processes (heating,pouring, spraying, spills and evaporation from large NIOSH has established new testing and certification surface areas such as open containers), and "confined requirements for negative pressure, air purifying, particulate space" exposures (working inside vats, reactors, boilers, filter and filtering facepiece respirators. The filter classifications of dust/mist/fume, paint spray or pesticideprefilters, and filters for radon daughters, have been Is the risk of getting sick higher for workers than for replaced with the N, R, and P series. Each series has three levels of filtering efficiency: 95%, 99%, and 99.9%. Check Yes. Exposures in the community, except possibly in with your safety equipment supplier or your respirator cases of fires or spills, are usually much lower than those manufacturer to determine which respirator is appropriate for found in the workplace. However, people in the community may be exposed to contaminated water as well If while wearing a filter or cartridge respirator you can smell, as to chemicals in the air over long periods. This may be a taste, or otherwise detect Estradiol, or if while wearing
problem for children or people who are already ill.
particulate filters abnormal resistance to breathing isexperienced, or eye irritation occurs while wearing a full facepiece respirator, leave the area immediately. Check to No. Most chemicals tested by scientists are not cancer- make sure the respirator-to-face seal is still good. If it is, replace the filter or cartridge. If the seal is no longer good,you may need a new respirator.
ESTRADIOL
--------------------------------------------------------------------------The following information is available from: New Jersey Department of Health and Senior ServicesOccupational Health ServicePO Box 360Trenton, NJ 08625-0360(609) 984-1863(609) 984-7407 (fax) Web address: http://www.state.nj.us/health/eoh/odisweb/ Industrial Hygiene Information
Industrial hygienists are available to answer your questions
regarding the control of chemical exposures using exhaust
ventilation, special work practices, good housekeeping, good
hygiene practices, and personal protective equipment including
respirators. In addition, they can help to interpret the results of
industrial hygiene survey data.
Medical Evaluation
If you think you are becoming sick because of exposure to
chemicals at your workplace, you may call personnel at the
Department of Health and Senior Services, Occupational Health
Service, who can help you find the information you need.
Public Presentations
Presentations and educational programs on occupational health
or the Right to Know Act can be organized for labor unions,
trade associations and other groups.
Right to Know Information Resources
The Right to Know Infoline (609) 984-2202 can answer
questions about the identity and potential health effects of
chemicals, list of educational materials in occupational health,
references used to prepare the Fact Sheets, preparation of the
Right to Know Survey, education and training programs,
labeling requirements, and general information regarding the
Right to Know Act. Violations of the law should be reported to
(609) 984-2202.
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ESTRADIOL
DEFINITIONS
ACGIH is the American Conference of Governmental Industrial
NAERG is the North American Emergency Response
Hygienists. It recommends upper limits (called TLVs) for Guidebook. It was jointly developed by Transport Canada, the United States Department of Transportation and the Secretariatof Communications and Transportation of Mexico. It is a guide A carcinogen is a substance that causes cancer.
for first responders to quickly identify the specific or generichazards of material involved in a transportation incident, and to The CAS number is assigned by the Chemical Abstracts
protect themselves and the general public during the initial Service to identify a specific chemical.
A combustible substance is a solid, liquid or gas that will burn.
NCI is the National Cancer Institute, a federal agency that
determines the cancer-causing potential of chemicals.
A corrosive substance is a gas, liquid or solid that causes
irreversible damage to human tissue or containers.
NFPA is the National Fire Protection Association. It classifies
substances according to their fire and explosion hazard.
DEP is the New Jersey Department of Environmental Protection.
NIOSH is the National Institute for Occupational Safety and
DOT is the Department of Transportation, the federal agency
Health. It tests equipment, evaluates and approves respirators, that regulates the transportation of chemicals.
conducts studies of workplace hazards, and proposes standardsto OSHA.
EPA is the Environmental Protection Agency, the federal
agency responsible for regulating environmental hazards.
NTP is the National Toxicology Program which tests chemicals
and reviews evidence for cancer.
A fetus is an unborn human or animal.
OSHA is the Occupational Safety and Health Administration,
A flammable substance is a solid, liquid, vapor or gas that will
which adopts and enforces health and safety standards.
PEL is the Permissible Exposure Limit which is enforceable by
The flash point is the temperature at which a liquid or solid
the Occupational Safety and Health Administration.
gives off vapor that can form a flammable mixture with air.
PIH is a DOT designation for chemicals which are Poison
HHAG is the Human Health Assessment Group of the federal
ppm means parts of a substance per million parts of air. It is a
IARC is the International Agency for Research on Cancer, a
measure of concentration by volume in air.
scientific group that classifies chemicals according to theircancer-causing potential.
A reactive substance is a solid, liquid or gas that releases
energy under certain conditions.
A miscible substance is a liquid or gas that will evenly dissolve
in another.
A teratogen is a substance that causes birth defects by
damaging the fetus.
mg/m3 means milligrams of a chemical in a cubic meter of air. It
is a measure of concentration (weight/volume).
TLV is the Threshold Limit Value, the workplace exposure limit
recommended by ACGIH.
A mutagen is a substance that causes mutations. A mutation is
a change in the genetic material in a body cell. Mutations can
The vapor pressure is a measure of how readily a liquid or a
lead to birth defects, miscarriages, or cancer.
solid mixes with air at its surface. A higher vapor pressureindicates a higher concentration of the substance in air andtherefore increases the likelihood of breathing it in.
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ESTRADIOL
HANDLING AND STORAGE
No Citation
Prior to working with Estradiol you should be trained on its
Estradiol is not compatible with OXIDIZING AGENTS (such
as PERCHLORATES, PEROXIDES, PERMAN-GANATES,
CHLORATES, NITRATES, CHLORINE, BROMINE and FLAMMABILITY
Store in tightly closed containers in a cool, well-ventilated REACTIVITY
If you are required to work in a "sterile" environment yourequire special training.
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate;3=serious; 4=severe FIRST AID
FIRE HAZARDS
For POISON INFORMATION call 1-800-222-1222 Use dry chemical, CO2, water spray, alcohol or polymer Eye Contact
Immediately flush with large amounts of water for at least 15 POISONOUS GASES ARE PRODUCED IN FIRE.
minutes, occasionally lifting upper and lower lids.
If employees are expected to fight fires, they must be trainedand equipped as stated in OSHA 1910.156.
Skin Contact
*
Remove contaminated clothing. Wash contaminated skin SPILLS AND EMERGENCIES
If Estradiol is spilled, take the following steps:
Breathing
*
Evacuate persons not wearing protective equipment fromarea of spill until clean-up is complete.
PHYSICAL DATA
Collect powdered material in the most convenient and safemanner and deposit in sealed containers.
Water Solubility: Insoluble
Ventilate and wash area after clean-up is complete.
It may be necessary to contain and dispose of Estradiol as a
OTHER COMMONLY USED NAMES
HAZARDOUS WASTE. Contact your state Department ofEnvironmental Protection (DEP) or your regional office of Chemical Name:
the federal Environmental Protection Agency (EPA) for Estra-1,3,5 (10)-Triene-3,17-Diol (17beta)- If employees are required to clean-up spills, they must be Other Names:
properly trained and equipped. OSHA 1910.120(q) may be ----------------------------------------------------------------------------- ============================================= Not intended to be copied and sold for commercial FOR LARGE SPILLS AND FIRES immediately call your fire department. You can request emergency information from the ----------------------------------------------------------------------------- NEW JERSEY DEPARTMENT OF HEALTH AND SENIOR SERVICES Right to Know Program
============================================= (609) 984-2202-----------------------------------------------------------------------------

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