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Material Safety Data Sheet
Methylprednisolone Sodium Succinate MSDS
Section 1: Chemical Product and Company Identification
Product Name: Methylprednisolone Sodium Succinate
Contact Information:
Catalog Codes: SLM3889
Sciencelab.com, Inc.
14025 Smith Rd.
CAS#: 2375-03-3
RTECS: TU4154060
US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: No products were found.
CI#: Not available.
CHEMTREC (24HR Emergency Telephone), call:
Synonym: Solu-Medrol, Solu-Medrone, Urbason
solubile, MPS; 6-alpha-Methylprednisolone sodiumsuccinate; 11-beta-17,21-Trihydroxy-6-alpha-methyl-1,4- International CHEMTREC, call: 1-703-527-3887
pregnadiene-3,20-dione 21-(sodium succinate) For non-emergency assistance, call: 1-281-441-4400
Chemical Name: Pregna-1,4-diene-3,20-dione,11-
beta,17,21-trihydroxy-6-alpha-methyl-, 21-(hydrogen
succinate), monosodium salt
Chemical Formula: C26-H33-Na-O8
Section 2: Composition and Information on Ingredients
Composition:
% by Weight
Toxicological Data on Ingredients: Methylprednisolone Sodium Succinate: ORAL (LD50): Acute: >5000 mg/kg [Rat].
>5000 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of
inhalation.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to blood, spleen, gastrointestinal tract, adrenal,
bones, pancreas. Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention if irritation occurs.
Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact: Not available.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
attention.
Serious Inhalation: Not available.
Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2). Some metallic oxides.
Fire Hazards in Presence of Various Substances:
Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Slightly explosive in presence of open flames and sparks. Non-explosive in presence of shocks.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards:
When heated to decomposition it emits acrid smoke and irritating fumes. As with most organic solids, fire is possible at
elevated temperatures
Special Remarks on Explosion Hazards:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion
hazard.
Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on
the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. If ingested, seek medical
advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents.
Storage:
Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in light-resistant
containers.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Powdered solid.)
Odor: Not available.
Taste: Not available.
Molecular Weight: 496.53 g/mole
Color: White.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Not available.
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: Not available.
Solubility: Not available.
Section 10: Stability and Reactivity Data
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Excess heat, incompatible materials, dust generation
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Not available.
Special Remarks on Reactivity: Sensitive to light.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
Section 11: Toxicological Information
Routes of Entry: Inhalation. Ingestion.
Toxicity to Animals: Acute oral toxicity (LD50): >5000 mg/kg [Mouse].
Chronic Effects on Humans: May cause damage to the following organs: blood, spleen, gastrointestinal tract, adrenal,
bones, pancreas.
Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: May cause adverse reproductive effects and birth defects (teratogenic)
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause
respiratory tract irritation. Ingestion: May cause nausea, and vomiting. May affect respiration, cardiovascular system, behavior/
central nervous system, blood, urinary system, spleen, hair, skin. Symptoms may include headache, increased intracranial
pressure, dizziness, seizures, insomnia, ataxia, restlessness, depression, anxiety, unusual moods, psychosis, euphoria,
personality changes, increased sweating, increased hair growth, reddened face, acne, thinned skin, easy bruising, tiny purple
skin spots, swollen feet, ankles, lower legs, muscle pain and weakness, stiffness, vision problems, puffy skin (especially
the face), general ateriolar or venous dilation, respiratiory depression, respiratory stimulation, chronic pulmonary edema,
cardiovascular arrythmias, cardiac arrest, congestive heart failure, hypotension, bradycardia . May also cause sodium and
fluid retention, hypokalemia, hypocalcemia, hyperglycemia, appetite stimulation or depression, increased susceptibility to
and masked symptoms of infection. Chronic Potential Health Effects: Ingestion: Prolonged or repeated ingestion may affect
urinary system, spleen(removal of old blood cells is dimished), adrenal gland (adrenal supression), blood (changes(decrease)
in white blood cell count, thrombocytopenia), immune system (supression of immune system), metabolism (weight loss or
weight gain), bones/joints (avascular necrosis, osteoporisis). May also cause ulceration or bleeding from the stomach or
duodenum, abdominal distention, ulcerative esophagitis, pancreatitis, allergic response (anaphylaxis), muscle weakness,
loss of muscle mass, Cushing's Syndrome, increased occular pressure and glaucoma, cataracts, exophthalmos, decreased
carbohydrate tolerance(glucose intolerance), manifestations of latent diabetes mellitus, increased requirements for insulin
or oral hypoglycemic agents in diabetes. Medical Conditions Aggravated by Exposure: There may an enhanced effect on
people with hypothyroidism, Diabetes, liver disease/cirrhosis. Also, existing emotional instability or psychotic tendencies
may be aggravated by corticosteroids. If there is a probability of impending perforation, abscess, or other pygenic infection;
diverticulitis; fresh, intestinal anastomoses, active or latent peptic ulcer; renal insufficiency; hypertension, osteoporosis,
myasthenia gravis.
Section 12: Ecological Information
Ecotoxicity: Not available.
BOD5 and COD: Not available.
Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).
Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
Federal and State Regulations: No products were found.
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the
European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada): Not controlled under WHMIS (Canada).
DSCL (EEC):
Not Available Not applicable.
HMIS (U.S.A.):
Health Hazard: 1
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 1
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.
Section 16: Other Information
References: Not available.
Other Special Considerations: Not available.
Created: 10/10/2005 12:45 AM
Last Updated: 11/06/2008 12:00 PM
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Source: http://hems.org/Resource%20Information/Medication%20Box%20MSDS%20Sheets/methylprednisolone_MSDS.pdf