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Prostate Cancer Studies
STUDIES CURRENTLY RECRUITING

ARN-509 - SPARTAN Study
Phase III study comparing ARN-509 (pill) to placebo for patients with non-metastatic
prostate cancer Recruiting

Galeterone - TOK ARMOR 2 study

2 part Phase II study of galeterone -TOK (pill) for patients with metastatic prostate
cancer pre and post-chemotherapy Recruiting

Genentec GDC + Zytiga

Phase II study of GDC + Zytiga, versus Zytiga alone for patients with advanced prostate
cancer previously treated with chemotherapy Recruiting

OGX-011 (Custersin) + Jevtana
Phase III study of Jevtana +/- Custersin second line chemotherapy for patients with
metastatic prostate cancer Recruiting
Prolia (denosunab)
Phase III study to evaluate Prolia for patients with prostate cancer taking hormones
Recruiting
Prostvac (vaccine)
Phase III study vaccination study for patients with advanced prostate cancer who have
not yet received treatment with chemotherapy and have no symptoms or minimal
symptoms Recruiting

Provenge PROCEED study (vaccine)
Registry study to collect long term safety data for patients receiving Provenge vaccine
Recruiting


Provenge PROCEED sub - study
Immune response study (additional blood samples collected) for patients participating in
PROCEED study Recruiting

PSMA ADC
Phase II study of PSMA ADC (target chemotherapy) in patients with metastatic prostate
cancer who have failed chemotherapy Recruiting

VT-464-CL-001 (testosterone inhibitor)
Phase I/II study to evaluate the safety of the study drug VT-464 (pill) and how it affects
patients with prostate cancer Recruiting
XL184 (Cabozantinib)
Phase II study comparing XL184 (Cabozantinib) (pill) vs. Prednisone only for patients
who have failed Zytiga (abiraterone) or Xtandi (MDV3100) Recruiting
Xtandi (MDV 3100) - STRIVE
Phase II study comparing Xtandi to standard of care Casodex for patients with Prostate
cancer Recruiting

Zytiga - Rising PSA IMAAGEN study
Phase III study of Zytiga plus prednisone for patients with rising PSA prostate cancer
who are receiving hormone therapy Recruiting

Androgen deprivation vs. Radiotherapy
Phase III study comparing androgen deprivation prior with pelvic lymph node dissection
vs. radiotherapy only Recruiting
Taxotere
Phase III study to evaluate the addition of Taxotere prior to surgery to improve outcome
for patients with newly diagnosed high risk prostate cancer Recruiting

Taxotere +/- GM-CSF
Phase II study of intermittent Taxotere vs. intermittent Taxotere with GM-CSF
Recruiting
STUDIES ACTIVE, CLOSED TO ENROLLMENT

TAK-700 (Orteronel) Pre-chemotherapy
Phase III study of TAK-700 plus prednisone for patients with advanced prostate cancer
who have not yet received treatment with chemotherapy Closed to enrollment –
active follow-up


TAK-700 (Orteronel) Post-chemotherapy
Phase III study of TAK-700 plus prednisone for patients with advanced prostate cancer
previously treated with chemotherapy Closed to enrollment – active follow-up

TAK-700 (Orteronel)
Phase II Open-label study of oral TAK-700 plus prednisone, evaluating the effects on
the heart for patients with advanced prostate cancer Closed to enrollment – active
follow-up


TAK-700 (Orteronel)
Phase II Open-label study of oral TAK-700 plus prednisone, evaluating dosing options
for patients with advanced prostate cancer Closed to enrollment – active follow-
up

Zytiga Cougar 302 study
Phase III study of oral Zytiga™ plus prednisone for patients with advanced prostate
cancer who have not yet received treatment with chemotherapy Closed to
enrollment – active follow-up

Zytiga + Provenge
Open-label Phase II study of Provenge with concurrent or sequential Zytiga.
Closed to enrollment – active follow-up

PRIOR STUDIES - CLOSED

Zytiga Cougar 301 study
Phase III study of oral Zytiga plus prednisone for patients with advanced prostate
cancer who have already received chemotherapy Closed
Zytiga EAP study
EAP oral Zytiga plus prednisone for patients with advanced prostate cancer who have
already received chemotherapy Closed

MDV3100 EAP study
EAP oral MDV3100 for patients with advanced prostate cancer who have already
received chemotherapy Closed

TroVax
Phase II study to evaluate the addition of TroVax vaccination to standard Taxotere
chemotherapy for patients with advanced prostate cancer Closed
OGX-011 (Custersin)
Phase III study of OGX-011 (Custersin) added to Taxotere for second line treatment
evaluation of pain palliation Closed
Eligard +/- Taxotere - Rising PSA
A Phase III study Eligard +/- Taxotere for patients with Rising PSA Closed

Source: http://www.gucancer.com/files/7613/6252/4706/Prostate_Cancer_Website_030513.pdf

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