Tih348281 711.714

Toxicology and Industrial Health25(9-10) 711–714 ª The Author(s) 2009Reprints and permission: http://www.
sagepub.co.uk/journalsPermission.navDOI: 10.1177/0748233709348281tih.sagepub.com William J Rea1, Yaqin Pan1 and Bertie Griffiths2 AbstractTwenty-eight incapacitated individuals (average 43 years old, 7 males, 21 females, range 12-70) exposed tomolds and mycotoxins were studied and treated with a protocol of cleaning up or changing their environmentto be mold free. Injections of the optimum dose of antigens were given as part of the treatment protocol as wasoral and intravenous (i.v.) antioxidants; heat depuration (sauna); physical therapy with massage and exerciseunder environmentally controlled conditions; oxygen therapy at 4-8 L/min for 2 hours with a special wood-grade cellophane reservoir and a glass oxygen container. Many patients were sensitive to plastics; therefore,exposures to these were kept to a minimum. Autogenous lymphocytic factor was given as an immune mod-ulator. Of 28 patients, 27 did well and returned to work. One patient improved but did not return to workduring the period of study.
KeywordsAntigens neutralization, anti-fungal drugs, oxygen, vitamins, chemical sensitivity, rotary duct and sinus, and nasal secretions. All the patients also hadintradermal provocation of their mycotoxins–aflatoxin, In an earlier study, we have reported our analysis of ochratoxin and tricothecene to explore mycotoxin mycotoxins in the air (Curtis et al., 2004; Rea et al., sensitivity. Of these patients, 28 were selected to follow 2003). The treatment of mycotoxicosis is extremely the aforementioned treatment protocol in the introduc- difficult because both the individual and the individu- tion. Patients were selected on the ability to clean their al’s environment must be treated for a successful houses by our criteria, the ability to precisely take their result. This treatment starts with reducing the total antigens, their ability to manipulate and take nutrients, environmental load and the total body load of molds, and by their ability to tolerate saunas. The patients were mycotoxins, and toxic chemicals followed by optimal treated in environmentally safe housing for a minimum dose neutralization injection of molds and mycotoxins of 3 weeks or until their homes were remodeled. All and other foods and chemicals to which the patient has become sensitized; oral and parenteral nutrition; Total environmental load (Rea, 1992, 1994) was heat depuration (environmentally clean sauna); exer- reduced by professional cleaning of the building cise and massage; if needed, immune modulators involved. Mold cultures were taken before and after such as autogenous lymphocytic factor, gammaglobu- the cleaning. Forty percent of the patients had to leave lin, and autogenous bacterial vaccines. If needed, the building permanently because even after the medications like anti-fungal drugs (Nystatin, Nizoral, cleaning and negative mold plates, they still could not Diflucan), cholestyramine, and activated charcoal tolerate the building. This intolerance appeared to be 1 Environmental Health Center - Dallas, TX, USA2 Between the years 2006 and 2008, 168 patients with American Environmental Health Foundation, USA mycotoxicosis were seen at the Environmental Health Center, Dallas. The patients were diagnosed by William J Rea, Environmental Health Center - Dallas, 8345 Walnut history, physical, urine, and analysis of sputum Hill Lane, Suite 220, Dallas, TX 75231, USA. Email: [email protected] Toxicology and Industrial Health 25(9-10) due to residual mycotoxin and/or the patient’s Table 1. Patients: 28, intradermal skin testing for inability to tolerate building repair and residual toxic chemicals that they could previously tolerate.
Total body load (Rea, 1997a,b,c) was reduced by having the patients drink less polluted glass bottled spring water and eat organic food with a rotary diet so that the patient would not eat the same food more than once in 4 days. The patients would avoid anyfood to which they were sensitive. The patients had Table 2. Patients: 28, urine mycotoxins: 32 to move out of the contaminated building where they Type of mycotoxin Before treatment After treatmentb lived or worked until it was deemed acceptable tothem.
The intradermal provocation-neutralization tech- nique (Lee et al., 1969; Rinkel, 1949) was used to test and treat the offending molds and mycotoxins (afla- toxins, ochratoxins, and tricothecenes). After an b Realtime Laboratories, Dallas, Texas, USA (Hooper, 2008).
appropriate starting dose was found, treatmentinjections were given subcutaneously every 4 days.
Nutritional supplementation (Rea, 1997a,b,c) was given orally consisting of vitamin C, 6000 mgm daily; All patients had an immune modulator (0.10 of the 1/ B1,2,3,5,6 100 mgm daily; B12 1000 mcg two times per 10 dilution of concentrate) made of 30 culture genera- week, and folic acid 1 mgm two times per week. Vita- tions of T-lymphocytes and processed according to min D3 400-1200 units per day, natural vitamin E 400- the method of Griffiths. Each patient had this 1200 IU daily and vitamin A 5000 units daily. Care autogenous lymphocytic factor given every 4 days.
must be taken to define the source, such as, corn,potato, beet, tapioca, soy, yeast, etc. Any vitamin that the patient could not tolerate was eliminated. Minerals All patients received one course of an anti-fungal drug were given daily, including calcium citrate 1000 mgm;magnesium citrate and aspartrate 500 mgm; zinc pico- of either Diflucan 1 tablet (100 mg.) per day for 2weeks or Nystatin 250,000 units every day for 1 linate or orotate 300 mgm; potassium citrate and aspar-tate 99 mgm; magnesium gluconate 10 mgm; copper gluconate 2 mgm; selenium methionine 200 mg;chromium 200 mgm; and molybdenum 200 mgm.
Essential and semi-essential amino acids (600- All patients had oxygen therapy using a glass water 2000 mgm) were given daily including L-tryptophan, reservoir, milk-grade tygon tubing, and a wood- lysine, leucine, isoleucine, cysteine, valine, threonine, derived cellophane reservoir 2 hours per day at 6-8 L methionine, arginine, and glutathione. Lipids as a (von Ardenne, 1990). For 18 days Wood-derived cello- source of omega 3 and 6 EPA plus DHA were also phane was used because patients could not tolerate given daily. Either three capsules or three teaspoon- synthetic petrochemicals in other plastics.
fuls were used. Salmon oil, cod oil, flax oil, primrose,borages, or black current oil was administered.
All 28 patients (7 males, 21 females, ages 12-70 years, average age 43 years) completed the study. Ninety- Heat depuration was preferred in environmentally five percent of the patients improved with treatment controlled saunas either conventional or infrared, being able to return to normal function. In all, 24% whichever the patient could tolerate. Sweating of patients had elevated tricothecene mycotoxins; 80% 20-30 min was allowed; and 20-30 min on an exer- returned to non-detectable at the end of the study; 6 cycle was followed by 20 min of deep massage – all had elevated aflatoxin and 100% became non- performed under environmentally controlled condi- detectable; and 2 had increased ochratoxins and both returned to normal (Tables 1 and 2).
necessary to treat the severe cases of mold/mycotoxin exposure as if they were chemically sensitive. Failure These patients were extremely sick and barely func- to reorganize the hypersensitive stage may result in less tional. It was clear that if they did not move out of the toxic building that they worked or lived in, they would Some patients in this series had such a damaged be incapacitated. This was because the minute they immune system that they had to have an immunomo- came into the building, their symptoms would start dulator to right the immune system. This substance is and then after a few minutes to hours, they become an autogenous lymphocytic factor developed by the non-functional. Many patients had damaged their sys- Environmental Health Center, Dallas. The process tems although the buildings were rendered mold free takes 6 weeks of incubation after the patient’s lym- after remediation; they still could not tolerate them.
phocytes are harvested from a blood draw (Griffiths Mold cultures were negative so it was presumed that et al., 1998). Injection of this substance every 4 days mycotoxins were still in the building; however, with appears to stimulate the T-cells to return to normal.
constant monitoring of the patient and with treatment Heat, depuration, and physical therapy appeared to one could see the mycotoxins going down until they decrease these patients’ total toxic load of mycotox- were eliminated (Table 2). This monitoring appeared ins. They became more energetic and less hypersensi- to be very important since some patients did at times increase their mycotoxins even though they appar- Nutrient replacement and supplementation was dif- ently were not exposed again. This temporary ficult in these patients because they were often hyper- increase appeared to be due to mobilization of the sensitive to the source, i.e. vitamin C-corn, Brewer’s toxics sequestered in the body since they were not yeast, etc. and could not tolerate them. Often, they had re-exposed to molds or mycotoxin. The patients to have injections to neutralize the source material.
continued to improve over time until they were well.
Nutrient supplementation was often necessary to Apparently, sauna, oral nutrients, and oxygen therapy (Rea, 1997a,b,c) helped neutralize and eliminate themycotoxins in the patients.
Oxygen therapy appears to be important in these With the aforementioned protocol, a small group of patients due to spasm and closure of parts of the specially selected severely ill patients were treated microcirculation caused by the mycotoxins. Once and improved. A larger group of patients should be these vessels opened, the patient’s detoxification sys- tems seemed to work better and the patient clearedmore rapidly (von Ardenne, 1990).
It was clear that avoidance alone did not stop the dis- The authors declared no conflicts of interest with respect to ease process from spreading as these patients had to the authorship and/or publication of this article.
have other therapy such as intradermal provocative neu-tralization testing and treatment not only for molds that they actually were initially exposed to but also to those Curtis L, Lieberman A, Stark M, Rea W, and Vetter M common in the outside air. The recognition of the che- (2004) Adverse health effects of indoor molds. Journal mically hypersensitive stage in mold and mycotoxin- of Nutritional and Environmental Medicine 14: 1–14.
exposed individuals is frequently overlooked. It can Griffiths BB, Rea WJ, Griffiths B, and Pan Y (1998) The role be ignored or does not even exist in the milder cases.
of the T lymphocytic cell cycle and an autogenous lym- These type of patients get well with the avoidance of the phocytic factor in clinical medicine. Cytobios 93: 49–66.
mold exposure and were not included in the series of 28 Hooper D (2008) The Hidden Truth of Mycotoxins and patients. Frequently, the injection of the optimum dose Developing the Future of Toxic Mold Testing Presenta- obtained by the neutralization technique rapidly stopped tion in 26th Annual International Symposium on Man the spreading phenomena and allowed these patients to and His Environment in Health and Disease. ‘‘Molds become less hypersensitive. In addition to the mold sen- and Mycotoxins, Hidden Connections for Chronic Dis- sitivity spreading, many of these patients developed a further spreading phenomenon in which they became Lee CH, Williams RI, and Binkley EL Jr (1969) Provoca- sensitive to foods and ambient chemicals. As our expe- tive testing and treatment for foods. Archives of Otolar- rience has grown, to obtain optimal results it appears Toxicology and Industrial Health 25(9-10) Rea WJ (1992) Chemical Sensitivity: Principles and Rea WJ (1997c) Chemical Sensitivity: Tools of Diagnosis Mechanisms. Boca Raton, FL: Lewis Publishers.
and Methods of Treatment. Boca Raton, FL: Lewis Rea WJ (1994) Chemical Sensitivity: Sources of Total Body Rea WJ, Didriksen N, Simon TR, Pan Y, Fenyves EJ, and Load. Boca Raton, FL: Lewis Publishers. Vol. II, Griffiths B (2003) Effects of toxic exposure to molds and mycotoxins in building-related illness. Archives of Rea WJ (1997a) Chemical Sensitivity: Tools of Diagnosis and Methods of Treatment. Boca Raton, FL: Lewis Pub- Rinkel HJ (1949) Inhalant allergy. Whealing response of skin to serial dilution testing. Annals of Allergy 7: Rea WJ (1997b) Chemical Sensitivity: Tools of Diagnosis and Methods of Treatment. Boca Raton, FL: Lewis von Ardenne M (1990) Oxygen Multistep Therapy.
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