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Antidepressants counteract tamoxifen’s recurrence-prevention effects Tamoxifen is an important medication used to help prevent recurrence of breast cancer. To work in the body, tamoxifen must be changed into a new molecule called endoxifen by an enzyme in the liver. The enzyme, called CYP4502D6 is genetically deficient in a minority of women, and these women do not get any benefit from u