Coenzyme q10 (coq10) deficiency

COENZYME Q10 (COQ10) DEFICIENCY & RISK FACTORS
“Treatment of periodontitis with CoEnyme Q10 [was so ‘extraordinarily effective’ that it] should be considered as adjunctive treatment with current dental practice.”35
“…topical application of CoQ10 improves adult periodontitis not only as a sole treatment but also in combination with traditional nonsurgical periodontal therapy.”36
Alzheimer's disease
Angina (severe chest pain, crushing chest pressure, e.g.) B12, C, &/or selenium deficiency, e.g.) Chronic coughing, wheezing, chest tightness
Bleeding of the gums with light brushing or probing. Chronic fatigue, lack of energy and vitality
Chronic gum disease (gingivitis, periodontitis)
Chronic fatigue syndrome
Elevated blood sugar & insulin levels (insulin resistance, Congestive heart failure/dilated cardiomyopathy type 2 diabetes--often associated with high blood Angina pectoris (chest pain due to heart disease) pressure, elevated cholesterol & triglycerides, Atherosclerosis
Elevated cholesterol
Heart disease & heart surgery
Mitral valve prolapse
Elevated total & LDL cholesterol
Heart disease, scheduled for heart surgery
High blood pressure (essential, systolic &/or
High blood pressure, systolic &/or diastolic High blood pressure
Muscle weakness
Hormone dependent cancers (breast cancer, e.g.) Hormone-dependent cancers (breast cancer, e.g.)
Periodontal Disease:
Insulin resistance, which is often associated with: Nutrient deficient diet (B2, B3, B5, B6, folic acid, • Gingivitis: Bleeding gums, gums that bleed with adult-onset diabetes/elevated fasting blood sugar light brushing or probing, swollen gums, reddened Type 2 diabetes, insulin resistance
• Periodontitis: Bleeding and pus with probing at the Use of anti-hypertensive medications (see list below) • elevated serum cholesterol and triglycerides gum-tooth margins, chronic inflammation of gums, infection, often with abscess formation, premature Prescription Medications That May Increase • sleep apnea
Kearns-Sayre syndrome (a chronic progressive ophthalmoplegia Poor muscle work tolerance (early muscle exhaustion Anti-Diabetic Drugs:
beginning in childhood, associated with short stature, hearing Diabeta, Glynase, Tolinase, Micronase, Dymmelor Beta Blockers:
Progressive muscle weakness with seizures Male Infertility
Selenium deficiency
Blood Pressure Medications:
Shortness of breath, difficulty breathing at rest
Multiple sclerosis
Vitamin deficiencies (C, B2, B3, B5, B6, folic acid &or Hydrochlorothiazide, Hydralazine, Clonidine Cholesterol Lowering Drugs:
Ophthalmoplegia (paralysis of some or all eye muscles)
Diets That Increase Risk of CoQ10 Deficiency Major Tranquilizers:
Diets high in animal protein, low in vegetables Tricyclic Antidepressants:
Diets deficient in riboflavin (vitamin B2), niacin (B3), Asendin, Elavil, Etrafon, Norpramin, Pamelor, pantothenic acid (B5) pyridoxine (B6), folic acid, B12, vitamin C &/or trace minerals such as selenium. For more information on CoQ10, go to www.life-span.com
COENZYME Q10 (COQ10) DEFICIENCY & RISK FACTORS Langsjoen H, et al., Usefulness of coenzyme Q-10 in clinical cardiology: A long term study. 20. Judy WV; Stogsdill WW; Folkers K Department of Medical Research and Anesthesiology, St. Mol Aspects Med 15, (Suppl.), S165-S175, 1994. Vincent Hospital, Indianapolis. Myocardial preservation by therapy with coenzyme Q10 Baggio E, et al., Italian multicenter study on the safety and efficacy of coenzyme Q-10 as during heart surgery. Clin Investig, 1993, 71:8 Suppl, S155-61 adjunctive therapy in heart failure. CoQ-10 Drug Surveillance Investigators. Mol Aspects 21. Folkers K; Drzewoski J; Richardson PC; Ellis J; Shizukuishi S; Baker L 22. Bioenergetics in clinical medicine. XVI. Reduction of hypertension in patients by therapy with Hamada M, Kazatani Y, Ochi T, et al., Correlation between serum CoQ-10 level and coenzyme Q10. Res Commun Chem Pathol Pharmacol, 1981 Jan, 31:1, 129-40 myocardial contractility in hypertensive patients. In: Biomedical and Clinical Aspects of 23. Pignatti C; Cocchi M; Weiss H Coenzyme Q10 levels in rat heart of different age. Biochem Coenzyme Q, Vol. 4. Folkers K and Yamamura Y (eds.). Elsevier Science Publ., 24. Götz ME; Gerstner A; Harth R; Dirr A; Janetzky B; Kuhn W; Riederer P; Gerlach M Clinical Morita K, et al.,Journal of Thoracic and Cardiovascular Surgery, 1995;110:1221-7. Neurochemistry, Department of Psychiatry, University of WÂurzburg, Federal Republic of Digiesi V, et al., Coenzyme Q-10 in essential hypertension. Mol Aspects Med 15, (Suppl.), Germany. Altered redox state of platelet coenzyme Q10 in Parkinson's disease. J Neural Langsjoen PH, Vadhanavikit S, and Folkers K, Response of patients in classes III and IV of 25. Bonetti A; Solito F; Carmosino G; Bargossi AM; Fiorella PL Chair of Sport Medicine, cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q-10. Proc Natl University of Parma, Italy. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. J Sports Med Phys Fitness, 2000 Mar, 40:1, 51-7 Mayell M, How to Use Herbs and Nutrients to Stay Well, 43. 26. Werbach MR UCLA School of Medicine, California, USA. Nutritional strategies for treating Lockwood K, Moesgaard S, and Folkers K, Partial and complete regression of breast cancer chronic fatigue syndrome. Altern Med Rev, 2000 Apr, 5:2, 93-108 in patients in relation to dosage of coenzyme Q-10. Biochem Biophys Res Comm 199, 27. Insulin resistance: lifestyle and nutritional interventions. Altern Med Rev, 2000 Apr, 5:2, 109- Balch J and Balch P, Prescription for Nutritional Healing, 10. 28. Sinclair S Green Valley Health, Hagerstown, MD 21742, USA. Male infertility: nutritional and 10. Balch J and Balch P, Prescription for Nutritional Healing, 10. environmental considerations. Altern Med Rev, 2000 Feb, 5:1, 28-38 11. Vanfraechem JHP and Folkers K, Coenzyme Q-10 and physical performance. In: Biomedical 29. Boitier E; Degoul F; Desguerre I; Charpentier C; François D; Ponsot G; Diry M; Rustin P; and Clinical Aspects of Coenzyme Q-10, Vol. 3. Folkers K and Yamamura Y (eds.) Marsac C INSERM U75, FacultÆe de MÆedecine Necker-Enfants Malades, Paris, Elsevier/ North-Holland Biomedical Press, Amsterdam, 1981, 235-241. France. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme 12. Balch J and Balch P, Prescription for Nutritional Healing. Q10 deficiency. J Neurol Sci, 1998, 156:1, 41-6 13. Folkers K Institute for Biomedical Research, University of Texas at Austin 78712, USA. 30. Folkers K; Langsjoen P; Nara Y; Muratsu K; Komorowski J; Richardson PC; Smith TH Relevance of the biosynthesis of coenzyme Q10 and of the four bases of DNA as a Institute for Biomedical Research, University of Texas, Austin 78712. Biochemical rationale for the molecular causes of cancer and a therapy. Biochem Biophys Res deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment. Biochem Biophys Res Commun, 1988 Jun, 153:2, 888-96 14. Vadhanavikit S; Ganther HE Department of Preventive Medicine and Community Health, 31. Folkers K; Brown R; Judy WV; Morita M University of Texas, Austin.Survival of cancer University of Texas Medical Branch, Galveston 77555, USA. Selenium deficiency and patients on therapy with coenzyme Q10. Biochem Biophys Res Commun, 1993 Apr, decreased coenzyme Q levels. Mol Aspects Med, 1994, 15 Suppl:, s103-7 15. Kishi H; Kishi T; Folkers K Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10- 32. Jolliet P; Simon N; Barré J; Pons JY; Boukef M; Paniel BJ; Tillement JP Service Hospitalo- enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, CrÆeteil, France. Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic 16. Bertazzoli C; Sala L; Ballerini L; Watanabe T; Folkers K Effect of adriamycin on the activity of consequences. Int J Clin Pharmacol Ther, 1998 Sep, 36:9, 506-9 the succinate dehydrogenase-coenzyme Q10 reductase of the rabbit myocardium. Res 33. Zierz S; Jahns G; Jerusalem F Neurologische UniversitÂatsklinik, Bonn, Federal Republic of Commun Chem Pathol Pharmacol, 1976 Dec, 15:4, 797-800 Germany Coenzyme Q in serum and muscle of 5 patients with Kearns-Sayre syndrome 17. Folkers K; Langsjoen P; Willis R; Richardson P; Xia LJ; Ye CQ; Tamagawa H University of and 12 patients with ophthalmoplegia. J Neurol, 1989 Feb, 236:2, 97-101 Texas, Austin 78712. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad 34. Hansen IL et al. Bioenergetics in clinical medicine. IX. Gingival and leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease. Res Commun Chem Pathol 18. Mortensen SA Department of Cardiology and Internal Medicine, Rigshospitalet B 2142, State Pharmacol, 1976 Aug; volume 14:4: pages 729-738. University Hospital, Copenhagen. erspectives on therapy of cardiovascular diseases with 35. Wilkinson EG et al. Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme coenzyme Q10 (ubiquinone). Clin Investig, 1993, 71:8 Suppl, S116-23 Q in periodontal therapy. Res Commun Chem Pathol Pharmacol, 1975 September; 19. Manzoli U; Rossi E; Littarru GP; Frustaci A; Lippa S; Oradei A; Aureli V Institute of Cardiology, Catholic University, Rome, Italy. Coenzyme Q10 in dilated cardiomyopathy. Int 36. Hanioka T; Folkers K et al. Department of Preventive Dentistry, Osaka University Faculty of Dentistry, Japan. Effect of topical application of coenzyme Q10 on adult periodontitis. Mol Aspects Med, 1994; volume 15 Suppl: pages s241-248.

Source: http://www.edwardsdrugs.com/PDF/moregeneralhealth/Risk%20Factors%20for%20CoQ10%20Deficiency.pdf