curriculum vitae

Roger Lloyd Bertholf
ADDRESS:
University of Florida Health Science Center
EDUCATION:

Degree (Major)
Institution

APPOINTMENTS:
Institution
University of Florida College of Medicine University of Florida College of Medicine University of Florida College of Medicine Post-Doctoral Research Associate University of Virginia School of Medicine University of Virginia School of Medicine
LICENSURE:
Clinical Laboratory Director license #DI28186, Florida Department of Health, Division of
Medical Quality Assurance (issued April, 1989; current license valid through August 2010)
CERTIFICATIONS:

Specialty


COURTESY APPOINTMENTS:
Institution

HONORS AND AWARDS:

Delta Sigma Rho – Tau Kappa Alpha National Honorary Forensic Society
Omicron Delta Kappa National Leadership Society
James Madison Leadership Society
Who’s Who in America
Who’s Who in American Colleges and Universities
Who’s Who in Science and Medicine
1999 Young Clinical Scientist Award (Association of Clinical Scientists)
2003 Clinical Scientist of the Year Award (Association of Clinical Scientists)
2003 Clinical Chemists Recognition Award (American Association for Clinical Chemistry)
2005 Diploma of Honor (Association of Clinical Scientists)
2007 Clinical Chemists Recognition Award (American Association for Clinical Chemistry)
ELECTED MEMBERSHIPS AND FELLOWSHIPS

Category
Organization
American Society of Clinical Pathologists National Academy of Clinical Biochemistry
MEMBERSHIPS IN PROFESSIONAL SOCIETIES:

Organization
American Association for Clinical Chemistry American Association for the Advancement of Science American Society of Clinical Pathologists
ELECTED OR APPOINTED OFFICES IN STATE AND NATIONAL
ORGANIZATIONS:

Organization
National Academy of Clinical Biochemistry Member (Appointed by Gov. Bush) Florida Board of Clinical Laboratory Florida Board of Clinical Laboratory Personnel National Academy of Clinical Biochemistry National Academy of Clinical Biochemistry Florida Board of Clinical Laboratory Personnel Florida Board of Clinical Laboratory Personnel Florida Chapter of the American Association for Clinical Chemistry American Association for Clinical Chemistry American Association for Clinical Chemistry
CURRENT PROFESSIONAL ACTIVITIES:

Activity
Director of Clinical Chemistry and Toxicology, Shands Jacksonville Hospital Clinical Laboratories Quality and Process Improvement Manager, Shands Jacksonville Hospital Clinical Laboratories Medical Director of Point-of-Care and Waived Laboratory Testing, Shands Jacksonville Hospital Medical Director of the School of Medical Technology, Shands Jacksonville Hospital
PAST PROFESSIONAL ACTIVITIES:

Activity
Medical Director of Outreach Laboratory Services, University Medical Center and University of Florida Health Science Center/Jacksonville, FL Scientific Director of Forensic Drug Testing, Southern Reference Laboratory, Jacksonville, FL Clinical Consultant, First Coast Medical Group Laboratory, Jacksonville, FL Director of Toxicology and Therapeutic Drug Monitoring, Shands Hospital Clinical Laboratories, Gainesville, FL Director of Forensic and Environmental Toxicology, University of Florida Diagnostic Referral Laboratories, Gainesville, FL Safety Officer, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine Section Chief, Computer Support, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine
COMMITTEE ASSIGNMENTS:

Committee
University of Florida College of Medicine Associate Professor Promotion and Tenure Committee Clinical Toxicology Advisory Committee, University of Florida Health Science Center/Jacksonville Shands Jacksonville Physician’s Systems Advisory Committee Chair, Borland Library Advisory Committee University of Florida Health Science Center Library Advisory Board University of Florida Health Science Center/Jacksonville Sexual Harassment Committee Chair, Dermatopathologist Search Committee, Department of Pathology, University of Florida Health Science Center/Jacksonville Vice-Chair and alternate member, Institutional Review Board (IRB-03), University of Florida Health Science Center/Jacksonville University of Florida Integrated Advanced Information Management Systems Task Force Chair, Institutional Review Board (IRB-03), University of Florida Health Science Center/Jacksonville Chair, Clinical Microbiologist Search Committee, Department of Pathology, University of Florida Health Science Center/Jacksonville Chair, Anatomical Pathologist Search Committee, Department of Pathology, University of Florida Health Science Center/Jacksonville Chair, Clinical Microbiologist Search Committee, Department of Pathology, University of Florida Health Science Center/Jacksonville University Medical Center Resource Management Committee University Medical Center Year 2000 Committee Executive Board, Center for Environmental and Human Toxicology, University of Florida Computer Committee, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine Pharmacy and Therapeutics Committee, Shands Hospital Interdisciplinary Graduate Toxicology Program Committee, Center for Environmental and Human Toxicology Operations Committee, University of Florida Diagnostic Referral Laboratories Graduate Program Committee, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine Florida Environmental Regulation Commission Ad Hoc Committee on the Health Effects of Lead Shands Hospital Laboratory Information Systems Steering Committee Shands Hospital Emergency Room Advisory Committee Chair, Biosafety Committee, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine Chair, Shands Hospital Medical Technology Program Admissions Committee Chair, Computer Committee, Department of Pathology and Laboratory Medicine, University of Florida College of Medicine
OTHER PROFESSIONAL ACTIVITIES:

Activity
Association
Annals of Clinical and Laboratory Science Clinical Chemistry Journal of Analytical Toxicology The Chemist Annals of Clinical and Laboratory Science Clinical and Forensic Toxicology News American Journal of Transplantation Pediatrics College of American Pathologists Clinical Laboratory Accreditation Program
TEACHING ACTIVITIES:

Clinical Chemistry and Toxicology Review: A comprehensive course for pathology residents Shands Jacksonville School of Medical Technology: Lectures in spectophotemetry, electrochemistry, immunochemistry, statistics, electrophoresis, proteins, lipids, tumor markers, toxicology, and therapeutic drug monitoring GMS 6312 Clinical Chemistry and Toxicology: Graduate course in the Department of Pathology and Laboratory Medicine GMS 6393 Seminars in Clinical Chemistry and Toxicology: Journal club in the Department of Pathology and Laboratory Medicine Laboratory Medicine: Section of the General Pathology course in the University of Florida College of Medicine VME 6602 General Toxicology: Graduate course in the University of Florida College of Veterinary Medicine CHM 6180 Recent Advances in Mass Spectrometry: Graduate course in the University of Florida Department of Chemistry; GRADUATE STUDENTS:

Thesis/Dissertation Title
Laboratory evaluation of intrauterine cocaine exposure and metabolism Detection of aluminum in white blood cells by flow cytometry and graphite furnace atomic absorption Determination of cocaine and its metabolites in specimens of neonatal and maternal origin
SUPERVISORY COMMITTEES:

Degree Year
Department
Department of Food Science and Human Nutrition (Interdisciplinary Toxicology Program) Department of Pharmaceutics (College of Pharmacy) Department of Pathology and Laboratory Medicine (College of Medicine) Department of Pharmaceutics (College of Pharmacy) Department of Pathology and Laboratory Medicine (Interdisciplinary Toxicology Program) Department of Pathology and Laboratory Medicine Department of Pathology and Laboratory Medicine (Interdisciplinary Toxicology Program)
GRANTS AND CONTRACTS:

Sponsor and Title
Roche Diagnostics: Performance evaluation of phenobarbital OnLine TDM on Hitachi Center/Jacksonville Dean’s Fund Grant: Influence of aluminum on magnesium-dependent enzymes: A potential model for aluminum toxicity. Roche Diagnostics: Performance evaluation of Roche Preciset TDM 1 multianalyte Roche Diagnostics: Performance evaluation phenobarbital OnLine TDM on Hitachi systems Roche Diagnostics: Performance evaluation of gentamicin and theophylline OnLine Roche Diagnostics: Multi-center evaluation of Roche acetaminophen on Hitachi systems Development of a GC/MS method for measuring cocaine and metabolites in placenta Roche Diagnostics: Multicenter study for the evaluation of the technical performance and clinical validity of CK/CKI-MB/LDH (IFCC) liquid reagents Validation of modified drug of abuse immunoassays at sub-threshold concentrations of cocaine, opiates, and cannabinoids University of Florida Health Science Center/Jacksonville: Disseminated Candidiasis: Role of urinary candidal casts, serum antigens, and fungal prophylaxis Coulter Corporation: Flow cytometric assessment of coronary endotheliel damage as a marker of Acute Myocardial Infarction Division of Sponsored Research, University of Florida: Award #94022414: Flow cytometric assessment of coronary endotheliel damage as a marker of acute myocardial infarction N.I.H. National Institute on Drug Abuse: Fetal cocaine metabolism and immunopharmacologic effect Evaluation of the Accu-Chek Easy blood glucose monitor using venous samples Beckman Instruments: Measurement of Valproic Acid on the Array 360 clinical 1991 – 1996 $2,297,293 N.I.H. National Institute on Drug Abuse: Project CARE (Cocaine Abuse in the Rural Environment); Award #R01 DA05854-01A2 PB Diagnostics: Evaluation of the OPUS Abbott Laboratories: Urinary cotinine assay Division of Sponsored Research, University of Florida: Neonatal cocaine metabolism (Graduate Assistantship on behalf of Nadia Lombardero-Tuttle) Aluminum induced cytoskeletal changes in cultured neurons; Award #88102727 Division of Sponsored Research, University of Florida: In vitro aluminum neurotoxicity;
PEER-REVIEWED PUBLICATIONS:
1. Bruns DE, Emerson JC, Bertholf RL, Hill KE, Savory J. Lactate dehydrogenase isoenzyme-
1 with the centrifugal analyzer after immunochemical removal of other isoenzymes. Clinical Chemistry 1981;27:922-3.
2. Bruns DE, Emerson JC, Intemann S, Bertholf R, Hill KE, Savory J. Lactate dehydrogenase
isoenzyme-1: Changes during the first day after acute myocardial infarction. Clinical Chemistry 1981;27:1821-3.
3. Bertholf RL, Renoe BW. The determination of bismuth in serum and urine by electrothermal
atomic absorption spectrometry. Analytica Chimica Acta 1982;139:287-95. 4. Bertholf RL, Brown S, Renoe BW, Wills MR, Savory J. Improved determination of
aluminum in serum by electrothermal atomic absorption spectrophotometry. Clinical Chemistry 1983;29:1087-9.
5. Smith BJ, Herold DA, Ross RM, Marquis FG, Bertholf RL, Ayers CR, Wills MR, Savory J.
Measurement of plasma prostaglandin E2 using capillary gas chromatography negative ion chemical ionization mass spectrometry. Research Communications in Chemical Pathology and Pharmacology 1983;40:73-86.
6. Bertholf RL, Roman JM, Brown S, Savory J, Wills MR. Aluminum hydroxide-induced
osteomalacia, encephalopathy and hyperaluminemia in CAPD. Treatment with desferrioxamine. Peritoneal Dialysis Bulletin 1984;4:30-2.
7. Brown S, Bertholf RL, Wills MR, Savory J. Electrothermal atomic absorption spectrometric
determination of aluminum in serum using a new protein precipitation technique. Clinical Chemistry 1984;30:1216-8.
8. Bertholf RL, Wills MR, Savory J. Quantitative study of aluminum binding to human serum
albumin and transferrin by a chelex competitive binding assay. Biochemical and Biophysical Research Communications 1984;125:1020-4.
9. Wills MR, Brown S, Bertholf RL, Ross R, Savory J. Serum and lymphocyte aluminum and
nickel in chronic renal failure. Clinica Chimica Acta 1985;145:193-6.
10. Bertholf RL, Wills MR, Savory J. Evaluation of equilibrium gel filtration chromatography
for the study of protein binding of aluminum in normal and uremic sera. Clinical Physiology and Biochemistry 1985;3:271-6.
11. Bertholf RL, Savory J, Wills MR. Desferrioxamine decreases protein-bound aluminum in
serum. Trace Elements in Medicine 1986;3:157-60.
12. Brown S, Mendoza N, Bertholf RL, Ross R, Wills MR, Savory J. Absorption of aluminum
from aceglutamide aluminum in healthy adult males. Research Communications in Chemical Pathology and Pharmacology 1986;53:105-16.
13. Savory J, Bertholf RL, Wills MR. Trace metals and degenerative diseases of the skeleton.
Acta Pharmacologica et Toxicologica (Copenh) 1986;59(Suppl 7):282-8.
14. Martin RB, Savory J, Brown S, Bertholf RL, Wills MR. Transferrin binding of Al3+ and
Fe3+. Clinical Chemistry 1987;33:405-7.
15. Bertholf RL, Nicholson JRP, Wills MR, Savory J. Measurement of lipid peroxidation
products in rabbit brain and organs (Response to aluminum exposure). Annals of Clinical and Laboratory Science 1987;17:418-23.
16. Bertholf RL, Winn-Deen ES, Bruns DE. Amylase in urine as measured by a single step
chromolytic method. Clinical Chemistry 1988;34:754-7.
17. Bertholf RL, Savory MG, Winborne KS, Hundley JC, Plummer GM, Savory J. Lithium
determined in serum with an ion selective electrode. Clinical Chemistry 1988;34:1500-2.
18. Bertholf RL, Herman MM, Savory J, Carpenter RM, Sturgill BC, Katsetos CD, VandenBerg
SR, Wills MR. A long-term model of aluminum maltol toxicity in rabbits: Tissue distribution, hepatic, renal, and neuronal cytoskeletal changes associated with systemic exposure. Toxicology and Applied Pharmacology 1989;98:58-74.
19. Vandeputte D, Van Grieken RE, Jacob WA, Savory J, Bertholf RL, Wills MR.
Ultrastructural localization of aluminium in liver of aluminium maltol-treated rabbits by laser microprobe mass analysis. Biomedical and Environmental Mass Spectrometry 1989;18:598-602.
20. Winter WE, Bertholf RL, Riley WJ, Maclaren NK, Obata M, Allen L.
Hypercholesterolemia: A common problem in Florida school-age children and adolescents. Annals of the New York Academy of Sciences 1991;623:472-5.
21. Bertholf RL, Sapp LM, Pittman DL. Failure of beta-glucuronidases from Patella vulgata to
hydrolyze exogenous morphine glucuronide. Clinical Chemistry 1991;37:759-60.
22. Bertholf RL, Bertholf MF, Brown CM, Riley WJ. Ionized calcium buffering in the
transfused anhepatic patient: Ab initio calculations of calcium ion concentrations. Annals of Clinical and Laboratory Science 1992;22:40-50.

23. Winter WE, Weber J, Sleater J, Bertholf RL. The Relationship of T-Uptake and T4 in Hypo-
and Hyperthyroid Patients. Clinical Chemistry 1993;39:554.
24. Lombardero N, Casanova O, Behnke M, Eyler FD, Bertholf RL. Measurement of cocaine
and metabolites in urine, meconium, and diapers by gas chromatography/mass spectrometry. Annals of Clinical and Laboratory Science 1993;23:385-94.
25. Pokorski TL, Chen WW, Bertholf RL. Use of urine cotinine to validate self-reports in U.S.
Navy recruits. Addictive Behaviors 1994;19:451-4.
26. Casanova OQ, Lombardero N, Behnke M, Eyler FD, Conlon M, Bertholf RL. Detection of
cocaine exposure in the neonate: Analyses of urine, meconium, and amniotic fluid from mothers and infants exposed to cocaine. Archives of Pathology and Laboratory Medicine 1994;118:988-93.
27. Phillips DR, Tebbett I, Bertholf RL. Comparison of HPLC and GC-MS for measurement of
cocaine and metabolites in human urine. Journal of Analytical Toxicology 1996;20:305-8.
28. Winecker RE, Goldberger BA, Tebbett I, Behnke M, Eyler FD, Conlon M, Wobie K, Karlix
J, Bertholf RL. Quantitative determination of cocaine and its metabolites in amniotic fluid
and umbilical cord tissue. Journal of Analytical Toxicology 1997;21:1-8.

29. Hattab EM, Goldberger BA, Johannsen LM, Kindland PW, Ticino F, Chronister CW,
Bertholf RL. Modification of screening immunoassays to detect sub-threshold
concentrations of cocaine, cannabinoids, and opiates in urine: Use for detecting maternal and
neonatal drug exposure. Annals of Clinical and Laboratory Science 2000;30(1):85-91.

30. Bennett AE, Bertholf RL. Discordant results of CK-MB and troponin I measurements: A
review of 14 cases. Annals of Clinical and Laboratory Science 2000;30(2):167-74.
31. Bertholf RL. Protecting human research subjects. Annals of Clinical and Laboratory

32. Winecker RE, Goldberger BA, Tebbett IR, Benhke M, Eyler FD, Karlix JL, Wobie K,
Conlon M, Phillips D, Bertholf RL. Detection of cocaine and metabolites in breast milk.
Journal of Forensic Science 2001;46:1221-1223.

33. Bertholf RL, Johannsen L, Benrubi G. False elevation of serum CA-125 level caused by
human anti-mouse antibodies. Annals of Clinical and Laboratory Science 2002;32(4):414 – 8.
34. Bertholf RL, Johannsen LM, Bazooband A, Mansouri, VF. False-positive acetaminophen
results in a hyperbilirubinemic patient. Clinical Chemistry 2003;49(4):695-8.
35. Bertholf RL, Menes M. Interpreting unusual results of thyroid function tests. Immunonotes:
AACC Clinical and Diagnostic Immunology Newsletter 2003;18(1):1-6.
36. Sanchez-Ramos L, Mentel C, Bertholf R, Kaunitz AM, Delke I, Loge C. Human chorionic
gonadotropin assay of cervicovaginal secretions as a predictor of preterm delivery. International Journal of Gynecology and Obstetrics 2003;83:151-7.
37. Bertholf RL. Statistical Methods for Establishing and Validating Reference Intervals.
Laboratory Medicine 2006;37:306-10.
38. Reisfield GM, Bertholf RL, Barkin RL, Webb FJ, Wilson GR. Physicians’ interpretative
knowledge of urine drug tests. Journal of Opioid Management 2007;3(2):80-8.
39. Reisfield GM, Salazar E, Bertholf RL. Rational use and interpretation of urine drug testing
in chronic opioid therapy. Annals of Clinical and Laboratory Science 2007;37(4):301-14.
40. Watson ID, Bertholf RL, Hammett-Stabler C. Drugs and ethanol testing at the point of care.

41. Reisfield GM, Webb FJ, Bertholf, RL, Sloan PA, Wilson GR. Family physicians’
proficiency in urine drug test interpretation. Journal of Opioid Management 2007;3(6):333-7. 42. Reisfield GM, Haddad J, Wilson GR, Johannsen LM, Voorhees KL, Chronister CW,
Goldberger BA, Peele JD, Bertholf RL. Failure of amoxicillin to produce false positive urine
screens for cocaine metabolite. Journal of Analytical Toxicology 2008;32(4):315-8

INVITED PAPERS AND CRITICAL REVIEWS:
1. Bertholf R. Biochemical analysis of bismuth. Clinical Chemistry News 1982;6:14-5.
2. Bertholf RL. Arsenic. Clinical Chemistry News 1985;11:6-10.
3. Savory J, Bertholf RL, Wills MR. Aluminum toxicity in chronic renal insufficiency. Clinics
in Endocrinology and Metabolism 1985;14:681-701.
4. Savory J, Bertholf RL, Boyd JC, Bruns DE, Felder RA, Shipe JR, Wills MR, Czaban JD,
Coffey KF, O'Connell KM. Advances in clinical chemistry over the past 25 years. Analytica Chimica Acta 1986;180:99-135.
5. Bertholf RL. Aluminum and Alzheimer's disease: Perspectives for a cytoskeletal
mechanism. CRC Critical Reviews in Clinical Laboratory Science 1987;25:195-210.
6. Savory J, Brown S, Bertholf RL, Mendoza N, Wills MR. Aluminum. Methods in

7. Bertholf RL, Bertholf MF. HELLP Syndrome. Clinical Chemistry News 1989;9:18-9.
8. Bertholf RL. Confirmatory testing for drugs of abuse in urine by gas chromatography/mass
spectrometry. The Chemist 1990;67:7-20.
9. Bertholf RL, Clark WJ. 6-Mercaptopurine. Clinical Chemistry News 1992;5:12-4.
10. Bertholf RL. From dipsticks to space stations. Point-of-care testing and the portable
laboratory. Jacksonville Medicine 1996;47:253-5.
11. Bertholf RL. Drug of abuse testing in the workplace. Jacksonville Medicine, 1996;47:341-3.
12. Bertholf RL, Bowman MA. Microbeads, magnets, and magic: The enchanting science of
immunochemistry. Annals of Clinical and Laboratory Science 1996;26:377-88.
13. Bertholf RL. Laboratory methods for detecting cocaine use during pregnancy. The Chemist

14. Bertholf RL. The expanding role of molecular biology in clinical chemistry. Cell Vision -
Journal of Analytical Morphology 1998;5(1):67-69.
15. Bertholf RL. Neonatal drug testing. Clinical and Forensic Toxicology News. 1999;June 1.

BOOKS
Bertholf RL and Winecker RE, editors. Chromatographic Methods in Clinical Chemistry and
Toxicology. John Wiley & Sons, Ltd., West Sussex, 2007.

BOOK CHAPTERS:
1. Bertholf RL, Wills MR, Savory J. Aluminum binding in plasma. In: Wills MR, Savory J,
eds. Aluminum Analyses in Biological Materials. Charlottesville: University of Virginia Press, 1983:126-33.
2. Savory J, Bertholf RL, Wills MR. Speciation and fractionation of toxic metals in biological
materials. In: Brown SS, Savory J, eds. Chemical Toxicology and Clinical Chemistry of Metals. London: Academic Press, 1983:183-98.
3. Bertholf R. Bismuth. In: Hicks JM, Parker KM, eds. Selected Analytes in Clinical
Chemistry. Washington: American Association for Clinical Chemistry,1984:67-9.
4. Herold DA, Ross RM, Marquis F, Redpath G, Facciolo-Arlinghaus A, Smith BJ, Bertholf
RL, Ayers CR, Wills MR, Savory J. Measurement of plasma prostaglandin E2 and F2α using
capillary gas chromatography negative ion chemical ionization mass spectrometry. In:
Sunderman FW, ed. Seminar on the Clinical Pathology of Reproductive Systems.
Philadelphia: Institute for Clinical Science, Inc., 1984:203-11.
5. Savory J, Brown S, Bertholf RL, Ross R, Wills MR. Serum and lymphocyte nickel and
aluminum concentrations in patients with extracorporeal hemodialysis. In: Brown SS, Sunderman Jr FW, eds. Progress in Nickel Toxicology. Proceedings of the Third International Conference on Nickel Metabolism and Toxicology. Paris, 1984:137-40.
6. Savory J, Brown S, Bertholf RL, Wills MR. Quantitative determination of aluminum. In:
Taylor A, ed. Aluminum and other Trace Elements in Renal Disease. London: Bailliere Tindall, 1986:246-59.
7. Bertholf RL, Wills MR, Savory J. Aluminum. In: Seiler, HG, Sigel H, Sigel A, eds.
Handbook on the Toxicity of Inorganic Compounds. New York: Marcel Dekker, Inc., 1988:55-64.
8. Bertholf RL. Zinc. In: Seiler, HG, Sigel H, Sigel A, eds. Handbook on the Toxicity of
Inorganic Compounds. New York: Marcel Dekker, Inc., 1988:787-800.
9. Savory J, Bertholf RL, Wills MR. General aspects of toxicology. In: Seiler HG, Sigel H,
Sigel A, eds. Handbook on the Toxicity of Inorganic Compounds. New York: Marcel Dekker, Inc., 1988:27-37.
10. Savory J, Brown S, Bertholf RL, Mendoza N, Wills MR. Aluminum. In: Riordan JF, Valle
BL, eds. Methods in Enzymology, vol 158(A). San Diego: Academic Press, Inc., 1988:289-301.
11. Bertholf RL, Estilong AJ. Forensic and clinical toxicology applications of ion trap mass
spectrometry. In: Sunderman FW, ed. Applied Seminar on Six Major Advances in Laboratory Medicine and Their Clinical Applications. Philadelphia: Institute for Clinical Sciences, Inc., 1991:197-231.
12. Schuster SM, Wylie DE, Bertholf RL, Soderholm KJ. Mercury specific monoclonal
antibodies as an analytical reagent for measurement of both soluble mercury and potential anti-mercury antibodies. In M.-M. Galteau, G. Siest, and J. Henry, eds. Biologie Prospective. Comptes rendus du 8Χ Colloque de Pont-Β-Mousson. John Libby Eurotext, Paris, 1993:371-6.
13. Bertholf RL. Gas Chromatography and Mass Spectrometry in Clinical Chemistry. In:
Meyers RA, ed. Encyclopedia of Analytical Chemistry: Instrumentation and Applications. John Wiley & Sons Ltd., Chichester, 2000:1314-36.
14. Bertholf RL. Environmental and chemical toxicology. In Wu A, ed.: Tietz Clinical Guide to
Laboratory Tests, 4th Edition. Saunders Elsevier, St. Louis, 2006.
15. Bertholf RL. Statistical methods for clinical laboratorians. In Clarke WA and Dufour, DR,
eds.: Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC, 2006:23-37.
16. Watson ID, Bertholf R, Hammett-Stabler C, Nicholes B, Smith B, George S, Welch S,
Verstraete A, Goldberger B. Drugs and Ethanol. In Nichols J, ed.: Laboratory Medicine Practice Guideline: Point of Care Testing. AACC Press, 2007. 17. Bertholf RL, Endres DB, Clarke W, Rhodes DG, Hawker CD, Christenson RH. Pre-
analytical variation, methods development, calculations, statistics, and evidence-based medicine. In: Wu A, ed. “Self-Assessment in Clinical Laboratory Science II,” AACC Press, Washington DC, 2008;1-43.
PUBLISHED ABSTRACTS:
1. Bruns D, Emerson J, Intemann S, Hill K. Bertholf, R, Savory J. Immunochemical assay of
lactate dehydrogenase isoenzyme-1: Application to the early diagnosis of acute myocardial infarction. Journal of Clinical Chemistry and Clinical Biochemistry 1981;19:628.
2. Bertholf RL, Renoe B, Wills MR, Savory J. Evaluation of a potential reference method for
serum aluminum using electrothermal atomic absorption spectrometry. Clinical Chemistry 1982;28:1590.
3. Bertholf RL, Wills MR, Savory J. Ultrafiltrable and dialyzable aluminum in normal and
uremic serum. Clinical Chemistry 1984;30:972.
4. Brown S, Bertholf R, Wills MR, Savory J. Measurement of aluminum in serum utilizing a
protein precipitation technique and electrothermal atomic absorption spectrometry. Clinical Chemistry 1984;30:972-3.
5. Savory J, Brown S, Bertholf RL, Ross R, Savory G, Wills MR. Serum and lymphocyte
nickel and aluminum concentrations in patients with extracorporeal hemodialysis. Annals of Clinical and Laboratory Science 1984;14:413-4.
6. Bertholf RL, Brown S, Mendoza N, Bruns DE, Wills MR, Savory J. Competitive binding
assay of aluminum binding to serum proteins. Clinical Chemistry 1985;31:992.
7. Brown S, Mendoza N, Bertholf RL, Ross R, Wills MR, Savory J. Absorption of aluminum
aceglutamide in normal subjects. Trace Elements in Medicine 1985;2:107-8.
8. Bertholf RL, Brown S, Wills MR, Savory J. Aluminum binding to proteins and small
molecules in the serum of Alzheimer's disease patients. Alzheimer's and Related Diseases: State of the Art in Research. Proceedings of a conference in Richmond, Virginia, March 11, 1985.
9. Bertholf RL, Herman MM, Sturgill BC, Katsetos CD, VandenBerg SR, Carpenter RM,
Savory J, Wills MR. Toxicity of intravenous aluminum maltol in young adult male rabbits. Journal of Neuropathology and Experimental Neurology 1988;47:360.
10. Bertholf RL, Savory MG, Winborne KH, Hundley JC, Savory J, Plummer GM. Evaluation
of the lithium ion-selective electrode on a DuPont Na/K/Li analyzer. Clinical Chemistry 1988;34:1170.
11. Vandeputte D, Savory J, Van Grieken RE, Jacob WA, Bertholf RL, Wills MR. Detection of
aluminum deposits in liver of rabbits treated with aluminum maltol. In: Abstract papers of the Seventh International Symposium on Mass Spectrometry in the Life Sciences, Ghent, Belgium August, 1988.
12. Winter WE, Bertholf RL, Riley WJ, Maclaren NK, Allen L. Screening for pediatric
hypercholesterolemia in Florida: A study of 3249 school age children and adolescents. Clinical Chemistry 1990;36:957-8.
13. Lombardero-Tuttle N, Casanova O, Behnke M, Eyler FD, Bertholf RL. Comparison of
specimens for GC/MS detection of prenatal cocaine exposure. Clinical Chemistry 1992;38:960.
14. Casanova OQ, Lombardero-Tuttle N, Eyler FD, Bertholf RL, Behnke M. Comparison of
drug history to maternal urine, infant's urine, and meconium for prenatal cocaine exposure. Pediatric Research 1992;31:243A.
15. Bertholf RL, Huggins M, Tennyson D, Lizer D, Hayden B. Immunoinhibition rate
nephelometric measurement of valproic acid on Beckman's Array 360 System: Comparison to fluorescence polarization immunoassay. Clinical Chemistry 1993;39:1243.
16. Nichols J, Bertholf R, Hemphill G, McLawhon R, White R, Dorn A, Hurt C, Akers C,
Ganser E, Robbins D, Foster-Swanson A. Multi-site evaluation of Boehringer Mannheim liquid-stable enzymatic ethanol reagent. Clinical Chemistry 1995;41:S125.
17. Winecker RE, Tebbett I, Goldberger BA, Bertholf RL. Utility of maternal hair for
determining prenatal cocaine exposure. Clinical Chemistry 1996;42:S222.
18. Bertholf RL, Picklesimer FL, Jr., Kindland PW, Johannsen LM. Use of lower threshold
concentrations of cocaine metabolite, cannabinoids, and opiates to enhance the clinical sensitivity of CEDIA drug of abuse assays for neonatal drug screening. Clinical Chemistry 1997;43:S202.
19. Bertholf RL. Soluble chemical markers of gastrointestinal and pancreatic tumors. Annals of
Clinical and Laboratory Science 1997;27:444.
20. Bertholf RL, Bennett AE. Discordant results of CK-MB and troponin I measurements: A
review of fourteen cases. Annals of Clinical and Laboratory Science 1999;29:231-2.
21. Bertholf RL. Application of molecular imprinting technology to immunoassays. Annals of
Clinical and Laboratory Science 2000;30:117.
22. Bertholf RL, Johannsen L, Huang W, Mansouri V. Erroneous detection of acetaminophen in
hyperbilirubinemic specimens. Annals of Clinical and Laboratory Science 2001;31:314-5.
23. Bertholf RL, Johannsen L, Coffing MJ. Performance and correlation studies of Roche
Diagnostics LDH IFCC liquid, CK NAC liquid, and Immune-inhibited CK-MB liquid reagents. Clinical Chemistry 2001;47:A35.
24. Klein G, Berger A, Bertholf R, Braun S, Brockett M, Cottenceau D, Junge W, Luthe H,
Treskes M. Multicenter evaluation of liquid reagents for CK, CK-MB and LDH with determination of reference intervals on Hitachi systems. Clinical Chemistry 2001;47:A30.
25. Bertholf RL. Case studies in human research ethics. Clinical Chemistry 2001;47:S14.

26. Otero CL, Bertholf RL. Correlation of surfactant/albumin (FLM II) and Lecithin
Sphingomyelin (L/S) ratios at near-threshold values for determining fetal lung maturity. American Journal of Clinical Pathology 2001;116:589.
27. Bertholf RL, Johannsen L. Falsely elevated CA-125 in a patient with low HAMA
concentration. Clinical Chemistry 2002;48(6) Supplement:A15.
28. Hon K, Bertholf R, Cobbaert CM, Engelmayer J, Johannsen L, LeGatt DF, Luthe H,
Oellerich M, Domke I. Multicenter evaluation of acetaminophen on Roche/Hitachi analyzers. Clinical Chemistry 2002;48(6) Supplement:A141.
29. Bertholf RL. Susceptibility of immunoassays to interference from human anti-animal
antibodies: How common a problem? Annals of Clinical and Laboratory Science 2002;32(3):318.
30. Sanchez-Ramos L, Mentel C, Bertholf R, Loge C, Delke I, Kaunitz AM. Quantitative β-hCG
levels from cervico-vaginal secretions for predicting preterm birth in symptomatic patients. American Journal of Obstetrics and Gynecology 2002;187(6):s125.
31. Sanchez-Ramos L, Mentel C, Loge C, Kaunitz AM, Bertholf R, Delke I. Rapid hCG testing
in cervico-vaginal secretions as a predictor of preterm birth in symptomatic patients. Obstetrics and Gynecology 2003;101(4):79S.
32. Bertholf RL, Johannsen L, Coffing MJ, Domke I, Engelmayr J, Flexer J, Lije D, Luthe H,
Minon J-M, Oellerich M, Wustemberger M. Theophylline measured by kinetic interaction of microparticles in solution (KIMS) homogeneous immunoassay. Clinical Chemistry 2003;49(6):A124.
33. Lilje D, Flexer J, Bertholf RL, Coffing MJ, Domke I, Engelmayr J, Johannsen L, Luthe H,
Minon J-M, Oellerich M, Wuertemberger M. Multicenter evaluation of Roche gentamicin OnLine TDM on Hitachi systems. Clinical Chemistry 2003;49(6):A121.

34. Bertholf RL, Perry S, Wears RL. Anatomy of a laboratory error. Annals of Clinical and
Laboratory Science 2003;33(3):360.
35. Roeddinger R, Luthe H, Rhode KH, Oellerich M, Bertholf RL, Johannsen L, Verstraete A,
De Vleeschauwer A, De Bel A, Kroll M, Coffing MJ, Sauter H, Roeddiger R. Multicenter evaluation of the new Roche Carbamazepine OnLine TDM assay developed for use on Roche Diagnostics/Hitachi analyzer systems. Clinical Chemistry 2004;50(6):A128.
36. Bertholf R, Johannsen L, Verstraete A, DeBel A, Jones J, Sargent D, Luthe H, Oellerich M,
Rhode KH, Roeddiger R, Sauter H, Coffing MJ. Phenytoin measured by kinetic interaction of microparticles in solution (KIMS) homogeneous immunoassay: Evaluation of the Roche OnLine TDM method in four hospital laboratories. Clinical Chemistry 2004;50(6):A133-4.
37. Bertholf RL, Huggins YM. Flow cytometric measurement of aluminum chloride, citrate, and
maltolate uptake by leucocytes. Annals of Clinical and Laboratory Science. 2004;34(3):360.
38. Bertholf RL, Thompson O. A systematic approach to reducing specimen misidentification
errors in the clinical laboratory. Annals of Clinical and Laboratory Science. 2004;34(3):368.
39. Bertholf RL. Medical errors: Finding the cause. Annals of Clinical and Laboratory Science.

40. Bertholf RL, Reisfield GM. Assessment of physicians’ ability to interpret urine drug
screening test results. Annals of Clinical and Laboratory Science 2007;37:201. 41. Bertholf RL, Reisfield GM. Cocaine metabolite assay results in patients taking amoxicillin:
Is there interference? Annals of Clinical and Laboratory Science 2008;38(2):187-8. 42. Bertholf R, Luthe H, Verstraete A, Johannsen L, Johnson K, Rhode K, Boussery L, Coppens
A, Coffing M J, Roeddiger R, Beck C. Multicenter Performance Evaluation of the Roche Phenobarbital ONLINE® TDM on Hitachi and Cobas Systems. Clinical Chemistry 2008;54(S6):A17.
UNPUBLISHED PRESENTATIONS:
1. Bertholf RL, Wills MR, Savory J. Aluminum binding in plasma. Presented at the
Conference on Aluminum Analysis in Biological Materials, held in Charlottesville, VA, June 29-30, 1983.
2. Bertholf RL, Savory J, Brown S, Wills MR. Aluminum binding to plasma proteins in
patients with dialysis encephalopathy and Alzheimer's disease. Presented at the Virginia Symposium on Research in Dementia and Related Diseases held in Norfolk, Virginia, May 18, 1984. (Presented by Dr. Savory).
3. Bertholf RL, Wills MR, Savory J. The effect of desferrioxamine on serum protein binding of
aluminum. Presented to the Virginia Chapter of the National Kidney Foundation Annual Scientific Session held in Charlottesville, VA, November 3, 1984.
4. Bertholf RL, Wills MR, Savory J. Quantitative study of aluminum binding to human serum
albumin and transferrin by a chelex competitive binding assay. Presented at the 7th Annual Instrumentation Symposium sponsored by the Capital Section of the AACC, held in Columbia, MD, December 5, 1984.
5. Bertholf RL. Aluminum and Alzheimer's disease. A historical and experimental perspective.
Presented to the University of Virginia Department of Pathology, January 29, 1985.
6. Bertholf RL. Chemical and histological aspects of aluminum neurotoxicity in vivo and in
vitro. Prospects for a model of Alzheimer's neuropathology. Presented to the University of Virginia Department of Pathology, June 2, 1987.
7. Bertholf RL. Clinical and experimental aspects of aluminum toxicity. Presented to the
medical staff of the Veteran's Administration Hospital, Salem, VA, April 4, 1988.
8. Winter WE, Bertholf RL, Riley WJ, Maclaren NK, Obata M, Allen L.
Hypercholesterolemia: A common problem in Florida school age children and adolescents. Presented at The NY Academy of Science Conference on Hyperlipidemia in Childhood and the Development of Atherosclerosis, held in Bethesda, MD, May 2-4, 1990. (Presented by Dr. Winter)
9. Bertholf RL. Drug Assay Equipment. Presented for the "Applying Clinical
Pharmacokinetics" workshop, sponsored by Shands Hospital Department of Pharmacy Services, held in Gainesville, FL, May 20-24, 1991.
10. Bertholf RL. Confirming drugs of abuse by mass spectrometry. Presented at the 1992 Joint
Annual Conference of Medical Laboratory Organizations, held in Altamonte Springs, FL,
11. Bertholf RL, Lombardero N, Casanova O, Eyler FD, Behnke M. Laboratory detection of
prenatal cocaine exposure. Presented at the 1994 Joint Annual Meeting of American Chemical Society Sections in Florida, held in Orlando, FL, May 5, 1994.
12. Phillips DL, Tebbett IR, Bertholf RL. Analysis of cocaine and metabolites by HPLC versus
GC/MS. Presented at the 208th Annual meeting of the American Chemical Society (Division of Analytical Chemistry), August 21, 1994. (Presented by Diane Phillips)
13. Bertholf RL. Review of automated immunochemistry. Presented at the Oregon Spring
Seminar, held in Eugene, Oregon, May 4, 1996.
14. Bertholf RL. The expanding role of molecular biology in clinical chemistry. Presented at
The 5th International Conference on Molecular Morphology and Molecular Biology in Diagnostic and Prognostic Pathology in Immunocytochemistry in Jacksonville, FL, October 5, 1997.
15. Bertholf RL. Laboratory aspects of workplace drug testing. Presented at the Southern
Reference Laboratories Seminar on workplace drug testing, in Jacksonville, FL, May 22, 1998.
16. Bertholf RL. Using drug of abuse screening immunoassays at sub-threshold concentrations:
Ways to improve the clinical sensitivity of non-forensic urine drug testing. Roundtable presented at the American Association for Clinical Chemistry 50th Annual Meeting in Chicago, IL, August 3, 1998.
17. Bertholf RL, Goldberger BA, Johannsen LM, Chronister CW, Hattab E. Use of CEDIA
screening methods for cocaine metabolite, cannabinoids, and opiates at sub-threshold concentrations: Improved sensitivity in clinical applications. Presented at the American Academy of Forensic Sciences 1999 Annual meeting in Orlando, FL, February 19, 1999.
18. Hattab EM, Bertholf RL, Goldberger BA, Chronister CW, Johannsen LM, Kindland PW,
Ticino F. Modification of screening immunoassays to detect sub-threshold concentrations of cocaine, cannabinoids, and opiates in urine: Use for detecting maternal and neonatal drug exposure. Presented at the University of Florida Health Science Center Jacksonville Research Day 1999, in Jacksonville, FL, May 14, 1999. (Presented by Dr. Hattab)
19. Bertholf RL, Bennett AE. Discordant results of CK-MB and troponin I measurements: A
review of fourteen cases. Presented at the University of Florida Health Science Center Jacksonville Research Day 1999, in Jacksonville, FL, May 14, 1999. (Presented by Dr. Bennett)
20. Bertholf RL. Laboratory methods for detection of prenatal exposure to cocaine. American
Society of Clinical Pathologists Teleconference presented on October 12, 2000.
21. Bertholf RL. Automated heterogeneous and homogeneous immunoassays: A review of
current technology. American Society of Clinical Pathologists Teleconference presented on March 22, 2001.
22. Otero CL, Bertholf RL. Correlation of surfactant/albumin (FLM II) and Lecithin
Sphingomyelin (L/S) ratios at near-threshold values for determining fetal lung maturity. Presented at the University of Florida College of Medicine Jacksonville Research Day, May 23, 2001. (Presented by Dr. Otero)
23. Mansouri VC, Bertholf RL, Johannsen L, Huang W. Hyperbilirubinemia interferes with
quantification of acetaminophen levels. Presented at the University of Florida College of Medicine Jacksonville Research Day, May 23, 2001. (Presented by Dr. Mansouri)
24. Bertholf RL. Applications of immunochemical methods in the clinical laboratory. Keynote
address at James Madison University Spring Research Symposium, April 12, 2002.
25. Hsieh E, Sanchez-Ramos L, Otero C, Bertholf R. Can the maturity threshold for the TDx-
FLM II test be safely lowered? Poster presentation at the UFHSC/Jacksonville Research Day, May, 2002. (Presented by Dr. Hsieh)
26. Mentel C, Sanchez-Ramos L, Bertholf R, Loge C, Delke I, Kaunitz A. Quantitative hCG
levels from cervico-vaginal secretions for predicting preterm birth in symptomatic patients. Platform presentation at the UFHSC/J research day, April 9, 2003. (Presented by Dr. Mentel)
27. Luthe,H, Bertholf RL, Coffing MJ, Domke I, Engelmayer J, Flexer J, Hohannsen L, Lilje D,
Minon JM, Oellerich M. Multicenter evaluation of new OnLine® TDM assays for determination of gentamicin and theophylline on Roche/Hitachi systems. Poster presentation at the 15th European Congress of Clinical Chemistry and Laboratory Medicine in Barcelona, Spain, June 1-5, 2003. (Presented by Dr. Luthe)
28. Röddiger R, Luthe H, Rhode K, Oellerich M, Bertholf R, Verstraete A, De Bel A, Jones J,
Coffing MJ, Sauter H. Multicenter evaluation of the new Roche phenytoin OnLine® TDM assay developed for use on RD/Hitachi analyzer systems. Poster presentation at the 15th European Congress of Clinical Chemistry and Laboratory Medicine in Barcelona, Spain, June 1-5, 2003. (Presented by Dr. Röddiger)
29. Bertholf RL, Nelson D. Protecting human research subjects: A review and case studies.
Edutrak session presented at the American Association for Clinical Chemistry Annual Meeting in Philadelphia, PA, July, 23, 2003.
30. Bertholf RL. Florida laws and rules governing clinical laboratory personnel. Presented at the
Joint CLMA-AACC Clinical Laboratory Symposium in St. Petersburg FL, October 7, 2004.
31. Bertholf RL. The emerging role of cardiac markers in emergency medicine. Presented at the
First Coast Point of Care Group meeting at St. Luke’s Hospital, Jacksonville, FL November 5, 2004.
32. Bertholf RL. Medical Errors: Causes and Prevention. Presented at the Jacksonville Area
Microbiology Society meeting at Shands Jacksonville Hospital, January 11, 2005.
33. Bertholf RL. Medical Errors: Causes and Prevention. Presented at the Transfusion Services
Supervisors meeting at Florida Georgia Blood Alliance, Jacksonville FL, June 1, 2005.
34. Bertholf RL. Florida laws and rules governing clinical laboratory personnel. Presented at the
Jacksonville Area Microbiology Society meeting at St. Luke’s Hospital, Jacksonville, FL, November 1, 2005.
35. Bertholf RL. Medical Errors: Causes and Prevention. Presented at Baptist Health,
Jacksonville FL, December 13, 2005 and January 17, 2006.
36. Bertholf RL. Prognostic value of troponin T and B-type natriuretic peptide in acute coronary
syndrome. Pathology Grand Rounds, University of Florida Health Science Center/Jacksonville, March 24, 2006.
37. Bertholf RL. Medical Errors: Causes and Prevention. Presented to the Jacksonville Area
Microbiology Society meeting Memorial Hospital, Jacksonville FL, January 9, 2007.
38. Bertholf RL. Medical Errors: Causes and Prevention. Presented at St. Vincent’s Hospital,
Jacksonville FL, February 13 and March 13, 2007.
39. Bertholf RL. The decentralized laboratory: Laws and regulations relating to point of care
testing. Presented at the Department of Anesthesiology Morning Conference M&M QA, May 30, 2007.
40. Bertholf RL. State and federal regulation of clinical laboratories in the United States.
Presented at Children’s Hospital in St. Petersburg, Russia, September 4, 2007.
41. Reisfield GM, Sloan PA, Bertholf RL, Webb FJ, Wilson GR. Urine drug test interpretation:
What do family medicine physicians know? Presented at the 3rd Symposium on Addictive & Health Behaviors Research at Amelia Island Plantation, FL, September 24-25, 2007.
42. Bertholf RL. Florida laws and rules governing clinical laboratory personnel. Presented at
Mayo Clinic, Jacksonville, FL, November 27, 2007. 43. Bertholf RL. Florida laws and rules governing clinical laboratory personnel. Presented at the
Jacksonville Area Microbiology Society meeting at Memorial Hospital, Jacksonville, FL, January 8, 2008.
44. Bertholf RL. Florida laws and rules governing clinical laboratory personnel. Presented at
Magnolia Educational Treasures Seminar (sponsored by the Southeastern state societies of American Medical Technologists and the Florida Coalition of Laboratory Professional Organizations), Panama City Beach, FL, February 22, 2008. 45. Bertholf RL. Florida laws and rules governing clinical laboratory personnel. Presented at St.
Vincent’s Hospital, Jacksonville, FL, April 8, 2008. 46. Bertholf RL. Creating Practice Standards on the use of Urine Drug monitoring in clinical
practice. Presented at the Tufts Health Care Institute Program on Opioid Risk Management: The role of urine drug monitoring and other biofluid assays in pain management. June 26, 2008. 47. Bertholf RL. Measuring free thyroxine: Challenges and controversies. Presented at the
University of Florida Health Science Center/Jacksonville Department of Medicine Research Conference, September 19, 2008.
WORKSHOPS FOR NATIONAL ORGANIZATIONS:

1. Shipe JR, Bertholf RL, Taylor HE. GC/MS data systems for qualitative and quantitative
analysis of drugs. Presented at the 3rd International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Philadelphia PA, May 26, 1993.
2. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Columbus OH, November 3, 1993.
3. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Chicago IL, May 11, 1994.
4. Winter WE, Bertholf RL. Autoimmune endocrinopathies. Presented at the American
Association for Clinical Chemistry Annual Meeting, in New Orleans LA, July 18, 1994.
5. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Washington DC, May 24, 1995.
6. Winter WE, Bertholf RL. Autoimmune endocrinopathies. Presented at the American
Association for Clinical Chemistry 47th Annual meeting in Anaheim, CA, July 17, 1995.
7. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in San Antonio TX, November 29, 1995.
8. Bertholf RL. Statistics in the clinical laboratory: Keys to understanding. Presented at the
American Society of Clinical Pathologists Workshop Week in Medical Technology in Anaheim CA, February 17, 1996.
9. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in San Francisco CA, March 27, 1996.
10. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Secaucus NJ, March 14, 1997.
11. Bertholf RL, Bowman MA. Immunochemical methods in the clinical chemistry laboratory.
Presented at the American Society of Clinical Pathologists Workshop Week in Medical
12. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory. Presented
at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Cleveland OH, September 10, 1998.
13. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory. Presented
at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Charlotte NC, October 29, 1998.
14. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory. Presented
at American Society of Clinical Pathologists Workshop Week in Medical Technology in San Francisco CA, March 1, 1999.
15. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry. Presented at the American Society of Clinical Pathologists Workshop Week for Medical Technology in Philadelphia PA, October 12, 1999.
16. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry. Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Atlanta GA, September 27, 2000.
17. Bertholf RL. Practical applications of statistical methods in the clinical laboratory. Presented
at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in San Antonio TX, November 29, 2000.
18. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory. Presented
at American Society of Clinical Pathologists Workshop Week in Medical Technology, in Anaheim CA, April 8, 2002.
19. Bertholf RL. Practical applications of statistical methods in the clinical laboratory. Presented
at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Anaheim CA, April 9, 2002.
20. Bertholf RL. Create more powerful presentations. [Workshop] Presented at the American
Association for Clinical Chemistry Annual Meeting in Orlando FL, July 29, 2002.
21. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry [Workshop]. Presented at the American Society of Clinical Pathologists Workshop Week for Medical Technology in Minneapolis MN, September 25, 2002.
22. Bertholf RL. Practical applications of statistical methods in the clinical laboratory
[Workshop]. Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Minneapolis MN, September 26, 2002.
23. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry. Part 1 [Workshop]. Presented at the American Society of Clinical Pathologists Workshop Week for Medical Technology in Chicago IL, April 23, 2003.
24. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry. Part 2 [Workshop]. Presented at the American Society of Clinical Pathologists Workshop Week for Medical Technology in Chicago IL, April 24, 2003.
25. Bertholf RL. Create more powerful presentations. [Workshop] Presented at the American
Association for Clinical Chemistry Annual Meeting in Philadelphia PA, July 22, 2003.
26. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry. Part 1. [Workshop] Presented at the American Society of Clinical Pathologists Workshop Week for Medical Technology in San Francisco CA, April 22, 2004.
27. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry. Part 2. [Workshop] Presented at the American Society of Clinical Pathologists Workshop Week for Medical Technology in San Francisco CA, April 23, 2004.
28. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] To be presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Baltimore MD, May 4, 2004.
29. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in San Francisco CA, April 7, 2005.
30. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshop Week in Medical Technology in Baltimore MD, May 4, 2005.
31. Bertholf RL. Laboratory statistics. [Review] Presented at Professional Practice in Clinical
Chemistry: A Review and Update, sponsored by the American Association for Clinical Chemistry, in Alexandria VA, May 15, 2005.
32. Bertholf RL. Chromatography and Ion Selective Electrodes. [Review] Presented at
Professional Practice in Clinical Chemistry: A Review and Update, sponsored by the American Association for Clinical Chemistry, in Alexandria VA, May 16, 2005.
33. Bertholf RL. Immunoassay. [Review] Presented at Professional Practice in Clinical
Chemistry: A Review and Update, sponsored by the American Association for Clinical Chemistry, in Alexandria VA, May 16, 2005.
34. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Chicago IL, May 26, 2005.
35. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Kansas City MO, September 21, 2005.
36. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry [Workshop]. Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Indianapolis, IN, September 21, 2006.
37. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry [Workshop]. Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Phoenix, AZ, November 9, 2006.
38. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in San Francisco, CA, March 8, 2007.
39. Bertholf RL. Laboratory statistics. [Review] Presented at Professional Practice in Clinical
Chemistry: A Review and Update, Washington, DC, April 22, 2007.
40. Bertholf RL. Pre-analytical variation. [Review] Presented at Professional Practice in Clinical
Chemistry: A Review and Update, Washington, DC, April 22, 2007.
41. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Secaucus, NJ, May 15, 2007.
42. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Springfield, MA, October 30, 2007.
43. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Phoenix, AZ, November 9, 2007. 44. Bertholf RL. Measuring free thyroxine. In Winter WE, moderator: Controversies in thyroid
function testing and interpretation: FT4, TSH, pregnancy, and MCT8. [Workshop] Presented at the American Association for Clinical Chemistry annual meeting in Washington DC, July 30, 2008. 45. Bertholf RL, Bowman MA. Immunochemical methods in the clinical laboratory.
[Workshop] Presented at the American Society for Clinical Laboratory Science annual meeting in Washington DC, July 29, 2008. 46. Bertholf RL. Practical applications of statistical methods in the clinical laboratory.
[Workshop] Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Atlanta GA, October 2, 2008. 47. Bertholf RL, Bowman MA. Interpreting Laboratory Tests—A case-oriented review of
clinical chemistry [Workshop]. Presented at the American Society of Clinical Pathologists Workshops for Laboratory Professionals in Dallas, TX, October 30, 2008.
BOOK REVIEWS, EDITORIALS, AND MISCELLANEOUS

1. Bertholf RL. Clinical Analyses of Bismuth: Analytical Considerations for Furnace Atomic
Absorption Spectrometry [Thesis]. Charlottesville, VA: University of Virginia, 1981:78pp.
2. Bertholf RL. Aluminum Binding to Plasma Proteins: A Study of the Speciation of
Aluminum in the Sera of Healthy, Uremic, and Alzheimer's Diseased Individuals [Dissertation]. Charlottesville, VA: University of Virginia, 1985:173pp.
3. Bertholf RL. Review of "Therapeutic drug monitoring and toxicology by liquid
chromatography," Wong SHY, ed. [Book Review]. Clinical Chemistry 1985;31:1255.
4. Bertholf RL. Essential and toxic metals [Quiz of the Month]. Clinical Chemistry News

5. Bertholf RL, Savory J. Aluminum toxicity in chronic renal failure: Treatment with
desferrioxamine [Case Study]. ASCP Check Sample Clinical Chemistry 1986;26:4.
6. Bertholf RL. Certification [Letter]. Clinical Chemistry News 1990;4:4.
7. Bertholf RL. Review of Protein Structure. New approaches to disease and therapy, by Max
Perutz. [Book review] The Chemist 1994;71(2):7.
8. Bertholf RL. Review of Bound Carbohydrates in Nature, by Leonard Warren [Book

9. Bertholf R. Flawed assumptions [Letter]. Roundel, June 1999.
10. Bertholf RL. Explaining kinetics [Letter]. Laboratory Medicine 2000;1:5.
11. Bertholf RL. Y2K effort too costly [Letter]. The Florida Times-Union January 14, 2000.
12. Bertholf RL. Biochemistry, professional ethics, and the legacy of Linus Pauling [Editorial].

13. Bertholf RL. Review of Introduction to Biochemical Toxicology. [Book review] The

14. Bertholf RL. Drug Testing: High standards upheld [Letter]. The Florida Times-Union

15. Bertholf RL, Goodison S. Television viewing and attention deficits in children. [Letter]

16. Bertholf RL. You gotta pass to score. Guest editorial for jaguars.com
http://www.jaguars.com/story/4446.asp. July, 2005.
17. Reisfield GM, Bertholf RL, Wilson GR. Opiates and opioids: What a difference a name
makes. Journal of Opioid Management 2007;3(4):179-80 [Editorial].
18. Bertholf RL. Report on the Association’s Field Trip to St. Petersburg, Russia, in September
2007. Clinical Science Trumpet: Newsletter of the Association of Clinical Scientists 2007;27(3):1-2. 19. Reisfield GM, Bertholf RL. “Practical guide” to urine drug screening clarified. Mayo Clinic
Proceedings 2008;83:848-9 [Letter].
IN PRESS, SUBMITTED, OR IN PREPARATION:
1. Bertholf RL. Laboratory statistics and quality control [Review]. To be presented at the
Professional Practice in Clinical Chemistry: Review and Update, in Alexandria VA, April 19, 2009. 2. Bertholf RL. Pre-analytical variation [Review]. To be presented at the Professional Practice
in Clinical Chemistry: Review and Update, in Alexandria VA, April 19, 2009. 3. Bertholf RL. Classic poisonings. [Review]. To be presented at the Professional Practice in
Clinical Chemistry: Review and Update, in Alexandria VA, April 20, 2009. 4. Bertholf RL. Thyroid [Review]. To be presented at the Professional Practice in Clinical
Chemistry: Review and Update, in Alexandria VA, April 21, 2009. 5. Reisfield GM, Chronister CW, Goldberger BA, Bertholf RL. Unexpected urine drug
monitoring results in a hospice patient on high dose morphine therapy. Clinical Chemistry [In press] 6. Bertholf RL and Reisfield GM. Minor metabolic products of opiate metabolism: potential
for misinterpretation of urine drug testing results. Accpeted for presentation at the Association of Clinical Scientists Annual Meeting in Tampa, FL, May 13 – 17, 2009. 7. Bertholf RL. Measuring free thyroxine. In: Controversies in thyroid function testing and
interpretation: FT4, TSH, pregnancy, and MCT8. [Workshop] Accepted for presentation at the American Association for Clinical Chemistry annual meeting in Chicago IL, July 20, 2009. 8. Bertholf RL. Urine drug testing in pain management: Challenges and opportunities.
[Roundtable] Accepted for presentation at the American Association for Clinical Chemistry annual meeting in Chicago IL, July 22, 2009. Revised: March 2, 2009

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