Tosca lucie flore

Laboratory address : UMR CNRS 8080 "Développement et Evolution" Université Paris-Sud IBAIC, Bât 444 91405 Orsay Cedex, FRANCE [email protected]
Education and research experiment:
2007-2009 Post-Doctoral position - National Center of Scientific Research (CNRS), Laboratory
of Developmental biology and Evolution, University Paris Sud, Orsay, France. Supervisor : B. Ciapa. → Role of the PLCγ et MEK/ERK pathways in the initiation of fertilization and mitotic calcium signals, apoptosis control and early development in the sea urchin. 2004-2007 Ph.D. (Reproductive biology) - University François Rabelais, Tours, France. Practical
training at the National Institute of Agronomical Research (INRA) of Nouzilly, France. Laboratory of Reproductive Physiology and Behavior. Supervisor : J. Dupont. → Role of 5’AMP-activated protein kinase (AMPK) in reproduction : characterization in ovary and pituitary. 2003-2004 Master’s Degree (Endocrinology and Cellular Interactions) - University of Medicine
Paris Sud, Kremlin Bicêtre, France. Practical training at the Atomic Energy Center (CEA), Fontenay-aux-Roses, France. Laboratory of Gametogenesis, Apoptosis and Genotoxicity. Supervisors : B. Lefèvre and C. Finaz. → Involvement of caspase-3 in meiotic and/or apoptosis during mouse oocyte in vitro maturation. International practical training: McGill Unversity, Royal Victoria Hospital of
Montreal, Canada. Laboratory of Reproductive Biology. Supervisor : R.C. Chian.
In vitro maturation, in vitro fertilization and in vitro embryo culture in bovine species. Main publications:
Tosca L, Chabrolle C, Dupont J. AMPK, Métabolisme et fertilité femelle. Med Sci 2008, 24(3):297-
Arnault E, Tosca L, Courtot AM, Doussau M, Pesty A, Finaz C, Allemand I, Lefèvre B. Presence of
caspase-2, caspase-3, and caspase-9 in the mature mouse oocyte: their roles during meiosis and/or
apoptosis in vitro. Dev Dyn 2008 (in revision).
Coyral-Castel S, Tosca L, Ferreira G, Jeanpierre E, Ramé C, Lomet D, Caraty A, Monget P, Chabrolle
C, Dupont J. The effect of AMPK activation on GnRH secretion in GT1-7 cells and its potential role in
hypothalamic regulation of the œstrus cyclicity in rats. J Neuroendocrinol 2008, 20(3):335-46.
Tosca L, Chabrolle C, Crochet S, Tesseraud S, Dupont J. IGF-1 receptor signaling pathways and
effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells. Domest
Anim Endocrinol 2008, 34(2):204-16.
Chung JT, Tosca L, Huang TH, Xu L, Niwa K, Chian RC. Effect of polyvinylpyrrolidone on bovine
oocyte maturation in vitro and subsequent fertilization and embryonic development. Reprod Biomed
Online 2007, 15(2):198-207.
Tosca L, Uzbekova S, Chabrolle C, Dupont J. Possible role of 5’AMP-activated protein kinase in the
metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation.
Biol Reprod 2007, 77(3):452-65.
Chabrolle C, Tosca L, Dupont J. Regulation of adiponectin and its receptors in rat ovary by human
chorionic gonadotrophin treatment and potential involvement of adiponectin in granuloca cell
steroidogenesis. Reproduction 2007, 133(4):719-31.

Tosca L,
Chabrolle C, Uzbekova S, Dupont J. Effects of metformin on bovine granulosa cells
steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase
(AMPK). Biol Reprod 2007, 76(3):368-78.
Expression of adiponectin and its receptors
(AdipoR1 and AdipoR2) in chicken ovary: Potential role in ovarian steroidogenesis. Domest Anim
Endocrinol 2007, 33(4):480-7.
Tosca Lactivation modulates progesterone secretion in granulosa cells from hen preovulatory follicles. J
Endocrinol 2006, 190(1):85-97.
in-induced stimulation of adenosine 5'
monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells.
Biol Reprod 2006, 75(3):342-51.
, Adenosine 5'-monophosphate-activated
protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology 2005,



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