Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.
Pa_cv_engl.doc
Address:
Telephone:
+33 380 293 507 + +33 380 0293 031, ext. 13393
Professional
• 2000: Senior Master Lecturer-Practitioner, University of Burgundy, Department of Biography
• 1989: Master Lecturer-Practitioner, University of Burgundy, Department of
• 1980: Lecturer-Practitioner, University of Burgundy, Department of Physiology
• 1975: Temporary Lecturer, University of Burgundy, Department of Physiology
• 1972: Temporary Lecturer, University of Strasbourg, Department of Biochemistry Education
• 1992: State Research Director Doctorate
• 1977: PhD, University of Strasbourg,
• 1973: Master degree in research, University of Strasbourg
• 1972: Degree in Biochemistry, University of Strasbourg
• 1969-1971: Degree in Physiology, University of Burgundy Expertises
• Cellular physiology and pharmacology
• experimental models in physiology, pharmacology and pathology
• biomedical electronics and clinical functional tests
Professional Research: memberships
• International Society for Heart Research (ISHR), European Section
• French Group of Cardiovascular Research (GRRC)
• French Society of Pharmacology and Therapeutics
Medical:
• French Club of Digestive Motility (CFMD)
• French Group of Paediatric Hepatology, Gastroenterology and Nutrition
Reviewer
• Cellular and Molecular Life Sciences
• Fundamental and Clinical Pharmacology
• Journal of Cardiovascular Pharmacology
CV of Pierre ATHIAS – Page 1 of 3 – ed. 6/29/2007
Teatching Medical University Diploma:
Medical BA:
Medical Masters:
• Physiology and Pharmacology of ion channels
• Fundamentals in Biomedical Technology
• Cellular Models in Experimental Research
Research Students
• Master Student: 16 as supervisor, 1 as co-supervisor
• PhD Students: 13 as supervisor, 3 as co-supervisor
Grants & National funding:
• French Ministry of Education, annual since 1991
• French Institute of Health and Medical Research (INSERM): 1993-1996
Regional funding:
• Regional Council of Burgundy, annual since 1987
Foundations:
• French Foundation for Medical Research: 1988, 1992
• French Federation of Cardiology : 2002, 2003, 2005
• Burgundy Heart Association: 2002, 2004
Publications
2002.- Tissier C, Bes S, Vandroux D, Fantini E, Rochette L, Athias P. Specific
(last 5 years)
electromechanical responses of cardiomyocytes to individual and combined components of ischemia. Can. J. Physiol. Pharmacol, 80: 1145-1157
2003.- Schaeffer, C., D. Vandroux, L. Thomassin, P. Athias, L. Rochette and J. L.
Connat. Calcitonin gene-related peptide partly protects cultured smooth muscle cells from apoptosis induced by an oxidative stress via activation of ERK1/2 MAPK. Biochim Biophys Acta 1643(1-3): 65-73.
2004.- Chantome, A., A. Pance, N. Gauthier, D. Vandroux, J. Chenu, E. Solary, J. F.
Jeannin and S. Reveneau. Casein kinase II-mediated phosphorylation of NF-kB p65 subunit enhances inducible nitric oxide synthase gene transcription in vivo. J Biol Chem. 279(23): 23953-60.
2004.- Gambert, S., S. Bes-Houtmann, D. Vandroux, C. Tissier, C. Vergely-Vandriesse,
L. Rochette and P. Athias. Deep hypothermia during ischemia improves functional recovery and reduces free-radical generation in isolated reperfused rat heart. J Heart Lung Transplant 23(4): 487-91.
2004.- Vandroux, D., C. Schaeffer, C. Tissier, A. Lalande, S. Bes, L. Rochette and P.
Athias. "Microtubule alteration is an early cellular reaction to the metabolic challenge in ischemic cardiomyocytes." Mol Cell Biochem 258(1-2): 99-108.
2004.- Bès, S., Tatou, E., Vandroux, D., Tissier, C., Rochette, L., Athias, P. Physiological
and metabolic actions of mycophenolate mofetil on cultured newborn rat
CV of Pierre ATHIAS – Page 2 of 3 – ed. 6/29/2007
cardiomyocytes in normoxia and in simulated ischemia. Fund Appl Pharm 18: 287-298.
2005.- Bès, S., Vandroux, D., Tissier, C., Tatou, Rochette, L., Athias, P. Direct protection
by cyclosporin A of rat cardiomyocytes from simulated ischemia dysfunctions. Eur. J. Pharmacol. 511: 109-120
2005.- Tissier, C., D. Vandroux, L. Devillard, A. Brochot, D. Moreau, L. Rochette and P.
Athias. Substrate dependence of the postischemic cardiomyocyte recovery: dissociation between functional, metabolic and injury markers. Mol Cell Biochem 273(1-2): 43-55.
2005.- Jacquir S., Binczak S., Laurent G., Athias P., Bilbault J.M. Influence of
geometrical constraints on propagation in cardiac tissue. Computers in Cardiology, 2005 : 647- 650.
2006.- Durot, I., L. Devillard, C. Tissier, D. Vandroux, S. Voisin, S. Jaquir, L. Rochette
and P. Athias "Dependence on the phospholipid polyunsaturated fatty acids of the oxidative injury of isolated cardiomyocytes." Free Radic Res 40(3): 251-61.
2006.- Devillard, L., Vandroux, D., Tissier, C., Brochot, A., Voisin, S., Rochette, Athias, P.
Tubulin ligands suggest a microtubule-NADPH oxidase relationship in postischemic cardiomyocytes. Eur. J. Pharmacol. 548 : 64-73.
2006.- Bopassa J. C., Vandroux D., Ovize M., Ferrera R. Controlled reperfusion after
hypothermic heart preservation inhibits mitochondrial permeability transition-pore opening and enhances functional recovery. Am. J. Physiol. Heart. Circ. Physiol. 291(5): H2265-71.
• 1996 - Laboratory for Myocardial Research, Institute of Biochemistry, The
lectures
Hebrew University, Hadassah Medical School, Jerusalem, Israel
• 2000 - VERTEX Phamaceuticals Inc., Oxford, UK
• 2004 - Servier-IDRS, Neuilly, France
• 2007 – 9th National Meeting of the Electronicians of the National Center of
Scientifc Research (CNRS), Dijon, France
Community
• Treasurer of the Health & Nutrition Branch of the Regional VITAGORA
involvement
• Head of the Office of Innovation, Valorization and Technology Transfer of the
Burgundy FEDERATION INSTITUTE OF HEALTH LABORATORIES
• Consultant of the Health Dept of the BURGUNDY DEVELOPMENT AGENCY
• Vice president of the regional CLUB OF TECHNOLOGICAL CONTRACTORS
Personal
• Horse dressage, show jumping and eventing
interests
CV of Pierre ATHIAS – Page 3 of 3 – ed. 6/29/2007
Tobacco Treatment Medication Dosing Chart Nicotine Patch Nicotine Gum Nicotine Lozenge Nicotine Nasal Spray Nicotine Inhaler Bupropion SR Varenicline Name/Generic Available Strength Time to peak Plasma level Possible Reactions * Additional * Additional warnings: warnings: see back Instructions Cost (Average) For Maximum
Association des Disciplines Orthodontiques et Maxillo-Faciales Le chirurgien maxillo-facial peut réaliser les extractions dentaires difficiles. - cas de dent dévitalisée et ankylosée. - cas d'extractions dents multiples. - présence de kyste plus ou moins volumineux attenant aux dents. - risques de complications hémorragiques du fait de traitement anti-agrégant (Aspégic®, Kardégic®, P