Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

Step therapy criteria

Step Therapy Criteria 2014 MSOFL_Medica Last Updated: 01/01/2014 ANTIDEPRESSANT THERAPY - UHCMR
Products Affected

Criteria
Step 1: One of the following Tier 1 or Tier 2 or Tier 3 antidepressants: SSRI, SNRI, bupropion, mirtazepine. Step 2: Emsam CAMPTOSAR INJECTION THERAPY - UHCMR
Products Affected

Criteria
Step 1: Irinotecan 20 mg/mL injection (generic). Step 2: Camptosar 20 mg/mL injection CNS STIMULANT THERAPY - UHCMR
Products Affected

Criteria
Step 1: Amphetamine/Dextroamphetamine combinations or Dextroamphetamine, or Dexmethylphenidate or Methylphenidate or a long acting methylphenidate. Step 2: Strattera COLY-MYCIN THERAPY - UHCMR
Products Affected

Criteria
Step 1: Colistimethate sodium 150 mg injection (generic). Step 2: Coly-Mycin 150 mg injection DDAVP INJECTION THERAPY - UHCMR
Products Affected

Criteria
Step 1: Desmopressin acetate 4 mcg/mL injection (generic). Step 2: DDAVP 4 mcg/mL injection ELLENCE INJECTION THERAPY - UHCMR
Products Affected

Criteria
Step 1: Epirubicin Injection Step 2: Ellence Injection EXELON THERAPY - UHCMR
Products Affected

Criteria
Step 1: One formulary oral acetylcholinesterase inhibitor. Step 2: Exelon transdermal systems FANAPT THERAPY - UHCMR
Products Affected

Criteria
Step 1: One of the following atypical antipsychotics: Geodon, Risperidone, Seroquel, Seroquel XR, Olanzapine, or Olanzapine ODT. Step 2: Fanapt IDAMYCIN INJECTION THERAPY - UHCMR
Products Affected

Criteria
Step 1: idarubicin injection (generic) Step 2: Idamycin PFS injection LEUKOTRIENE MODIFIER ASTHMA THERAPY - UHCMR
Products Affected

Criteria
Step 1: Formulary Singulair or generic montelukast. Step 2: Zyflo CR or Zyflo NIPENT THERAPY - UHCMR
Products Affected

Criteria
Step 1: Pentostatin injection (generic). Step 2: Nipent injection PHOSLYRA THERAPY - UHCMR
Products Affected

Criteria
Step 1: Calcium acetate or Renvela. Step 2: Phoslyra RANEXA THERAPY - UHCMR
Products Affected

Criteria
Step 1: Any one preferred tier: Long-acting nitrate, Beta-blocker, or Calcium-channel blocker. Step 2: Ranexa RENAGEL THERAPY - UHCMR
Products Affected

Criteria
TOPICAL IMMUNOMODULATOR THERAPY - UHCMR
Products Affected

Criteria
Step 1: Any one preferred tier topical Corticosteroid. Step 2: Elidel or Protopic UCERIS THERAPY- UHCMR
Products Affected

Criteria
Step 1: Any ONE formulary preferred agent from the following: rectal 5-ASA, oral 5-ASA, oral corticosteroid, or rectal corticosteroid. Step 2: Uceris ULORIC THERAPY - UHCMR
Products Affected

Criteria
VFEND THERAPY - UHCMR
Products Affected

Criteria
Step 1: Generic voriconazole. Step 2: Brand Vfend VIOKACE THERAPY - UHCMR
Products Affected

Criteria
Step 1: Any one formulary preferred tier pancreatic enzyme. Step 2: Viokace ZOFRAN INJECTION THERAPY - UHCMR
Products Affected

Criteria
Step 1: ondansetron injection (generic). Step 2: Zofran injection Plans are insured or covered by UnitedHealthcare Insurance Company or one of its affiliates, a Medicare Advantage organization with a Medicare contract and a Medicare-approved Part D sponsor. [<OVEX3386716_000>] <Formulary ID#> 00014395 Y0066_130404_093413 CMS Approved

Source: http://mypreferredportal.com/media/2489/14395_Formulary-MSOFL_ST-Web-File-MEDICA-Mike-Haran-edits-092313-236pm.pdf