Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

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STEP THERAPY PROGRAM FOR ASCENSION HEALTH
JULY 2013
***Most step therapy programs have exception criteria for members taking certain medications and/or medical histories. Depending on a member's specific medical history, a step two medication may be
approved without a trial of a first step medication.***
Step Therapy Program
Targeted drugs
First step drugs
This program looks for
benazepril, benazepril/HCTZ, captopril, captopril/HCTZ, enalapril, enalapril/HCTZ, fosinopril, Benicar, Benicar HCT, Edarbi, Edarbyclor, Exforge, fosinopril/HCTZ, lisinopril, lisinopril/HCTZ, ramipril, Previous rx for ACE inhibitor or ACE combination AND generic
Angiotensin II Receptor Antagonists (ARBs): Exforge HCT, Micardis, Micardis HCT, Teveten, Teveten quinapril, quinapril/HCTZ, moexipril, trandolapril, ARB or generic ARB combination required.
moexipril/HCTZ, candesartan, candesartan/HCTZ, irebsartan, irebsartan/HCTZ, losartan, losartan/HCTZ, valsartan/HCTZ cambamzepine, divalproex, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, topiramate, Prior use of generics as 1st line agentsvalproate, valproic acid, zonisamide Prior use of 1 first line generic medication: Aplenzin requires Aplenzin, Desvenlafaxine ER tabs, Luvox CR, Oleptro, generic bupropion XL first; Oleptro requires immediate release Pexeva, Pristiq, Prozac/Weekly, Sarafem, Viibryd olanzapine, quetiapine, risperidone or ziprasidone alfuzosin, doxazosin, finasteride, tamsulosin or Advicor, Altoprev, Crestor, Lescol, Lescol XL, Livalo, atorvastatin, atorvastatin/amlodipine, lovastatin, Prior use of two generic statins; Zetia concurrent use of any 2 of any of the following; diclofenac, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, COX-2 Inhibitors; naproxen + esomeprazole indomethacin, ketoprofen, ketorolac, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, salsalate or sulindac Actosplus Met XR, Avandamet, Avandaryl, Avandia, Cycloset, Duetact, Invokana, Janumet, Janumet XR, metformin, metformin-glyburide, metformin-glipizide, Januvia, Jentadueto, Juvisync, Kazano, Kombiglyze XR, or sulfonylureaNesina, Oseni, Onglyza, Tradjenta Edluar, Intermezzo, Lunesta, Rozerem, Silenor, Sonata, Alsuma, Axert, Frova, Imitrex, Maxalt/MLT, Relpax, naratriptan, rizatriptan, sumatriptan or zolmitriptan Prior use of vancomycin AND oral metronidazole Avonex, Betaseron, Copaxone, Rebif, Extavia Concurrent use of 1 first line medication STEP THERAPY PROGRAM FOR ASCENSION HEALTH
JULY 2013
***Most step therapy programs have exception criteria for members taking certain medications and/or medical histories. Depending on a member's specific medical history, a step two medication may be
approved without a trial of a first step medication.***
Step Therapy Program
Targeted drugs
First step drugs
This program looks for
Detrol LA, Ditropan XL, Enablex, Gelnique, Myrbetriq, oxybutynin immediate release, oxybutynin extended Immediate release gabapentin for Gralise Generic ropinerole or pramipexole for Horizant Betamethasone dipropionate, desoximetasone, Prior use of generic oral diclofenac for Pennsaid; any generic

Source: https://mp.medimpact.com/brandcontentprovider/ASC/MP/current_step_therapy.pdf