Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

Medicalexaminer.cuyahogacounty.us

Office of the Cuyahoga County Medical Examiner’s Office 11001 Cedar Avenue, Cleveland, Ohio 44106 DRUGS ANALYZED/QUANTIFIED BY CCRFSL/CCMEO TOXICOLOGY VOLATILES: Acetaldehyde, Acetone, Acetonitrile*, Butane, Chloroform*, Dichloromethane*, Ethanol, Ethyl Acetate*, Formaldehyde, Isopropanol, Methane,
Methanol, Paraldehyde*, Propane, Toluene*. ETHANOL, ACETONE, ISOPROPANOL, and METHANOL CONFIRMATION(s) by alternative GC column
and/or alternative specimens. METHANOL is differentiated from FORMALDEHYDE by Colorimetry (Qualitative).
Sedatives, Hypnotics, Anti-Epileptic and Other Acidic/Neutral Drugs:
Amobarbital, Butalbital, Caffeine, Carbamazepine, Carisoprodol, Glutethimide, Ibuprofen, Levetiracetam, Mephenytoin, Meprobamate, Metaxalone, Naproxen, Pentobarbital, Pentoxifylline, Phenobarbital, Phenytoin, Primidone, Secobarbital, Theophylline, Topiramate; ACIDIC NEUTRALs Screened and Quantified by GC-FID and Confirmed by GC/MS.
CARBON MONOXIDE*(Carboxyhemoglobin) by CO-Oximetry: Carbon Monoxide, Methemoglobin, Hemoglobin; CARBON MONOXIDE CONFIRMATION by
Spectrophotometry and/or Microdiffusion.
GLYCOLS*: Ethylene Glycol, Propylene Glycol Screened and Confirmed by GC/MS.
CYANIDE*: Screened and Quantified by Colorimetry.
EMITSCREEN: SYMPATHOMIMETIC AMINES (SMAs) (target = d-Amphetamine); BENZODIAZEPINES (Target= Oxazepam);
COCAINE (Target= Benzoylecgonine (a cocaine metabolite); CANNABINOIDS (Target= 11-nor--9-THC-COOH (a marijuana metabolite);
OPIATES (Target= Morphine); PHENCYCLIDINE (Target= Phencyclidine).

7)
ELISA (Enzyme-Linked ImmunoSorbent Assay) SCREEN: SMAs (Target = d-Amphetamine); Barbiturates (Target = Pentobarbital); Benzodiazepines (Target =
Alprazolam); Cannabinoids (Target = 11-nor--9-THC-COOH (a marijuana metabolite); Carisoprodol (Target = Carisoprodol); Cocaine Metabolite (Target =
Benzoylecgonine); Fentanyl (Target = Fentanyl); Methamphetamine (Target = d-Methamphetamine); Oxycodone (Target = Oxycodone); Phencyclidine (Target =
Phencyclidine); Tricyclic Antidepressants (Target = Nortriptyline); Methadone (Target = Methadone); Opiates (Target = Morphine).
BASIC DRUGS by GC/MS (Quantitation and Confirmation): Amantadine, Amitriptyline, Amoxapine, Amphetamine, Atropine, Benztropine, Brompheniramine,
Bupivacaine, Bupropion, Bupropion Metabolites, Buspirone, Caffeine, Carbinoxamine, Chlorophenylpiperazine, Chlorpheniramine, Chlorpromazine, Citalopram,
Clomipramine, Clozapine, Cocaethylene, Cocaine, Codeine, Cocaine and metabolites, Cotinine, Cyclizine, Cyclobenzaprine, Desalkylflurazepam, Desipramine, Desmethyl
Chlordiazepoxide, Desmethyl Clomipramine, Desmethyl Clozapine, Desmethylsertraline, Desmethylvenlafaxine, Dextromethorphan, Diazepam, Diethylpropion,
Diphenhydramine, Disopyramide, Diltiazem, Doxepin, Doxylamine, Ecgonine methyl ester, Ephedrine/Pseudoephedrine, Fenfluramine, Fentanyl, Fluoxetine,
Fluvoxamine, Guaifenesin, Haloperidol, Hydrocodone, Hydroxyzine, Imipramine, Ketamine, Laudanosine, Lidocaine, Lidocaine mb (MEGX), Loxapine, Maprotiline,
Meclizine, Meperidine, Mephentermine, Mesoridazine, Methadone, Methadone primary mb (EDDP), Methadone secondary mb (EMDP), Methamphetamine, Methylene-
dioxyamphetamine (MDA), Methylenedioxymethamphetamine (MDMA), Methylenedioxypyrovalerone (MDPV), Methylphenidate, Metoprolol, Mexiletine, Midazolam,
Mirtazapine, Nefazodone, Nicotine, Nordiazepam, Nordoxepin, Norfluoxetine, Normeperidine, Norpropoxyphene, Nortriptyline, Norverapamil, Olanzapine, Orphenadrine,
Oxycodone, Papaverine, Paroxetine, Pentazocine, Pentoxifylline, Perphenazine, Phencyclidine, beta-Phenethylamine, Pheniramine, Phendimetrazine, Phenmetrazine,
Phentermine, Phenylpropanolamine, Phenytoloxamine, Procaine, Promethazine, Propoxyphene, Propranolol, Protriptyline, Pseudoehedrine, Pyrilamine, Quetiapine,
Quinidine, Quinine, Sertraline, Thioridazine, Tramadol, Tranylcypromine, Trazodone, Trihexylphenidyl, Trimipramine, Venlafaxine, Verapamil, Zolpidem.
ACETAMINOPHEN SCREEN: Acetaminophen by Colorimetry (Qualitative).
SALICYLATE SCREEN: Salicylate (Aspirin) by Colorimetry (Qualitative), SALICYLATE CONFIRMATION by Gas Chromatography.
XANTHINES by GC/MS: Acetaminophen, Caffeine.
CLINICAL CHEMISTRIES (CHEM7): Ketones, pH, Specific Gravity, and Electrolytes (Sodium, Potassium, Chloride, TCO2, Glucose, Urea, Creatinine).

13) COCAINE CONFIRMATION by GC/MS: Anhydroecgonine methyl ester, Benzoylecgonine, Cocaine, Cocaethylene, Ecgonine ethyl ester*, Ecgonine methyl ester.
CANNABINOIDS by GC/MS: Cannabinoids (ng/mL; mcg/L): D9-THC, 11-OH-D9-THC (a marijuana metabolite), 11-nor- D9-THC-COOH (a marijuana metabolite),
TOTAL11-nor- D9-THC-COOH (a marijuana metabolite).
OPIATES by GC/MS (ng/mL): Morphine, 6-Acetylmorphine (heroin metabolite), Codeine, Hydrocodone, Dihydrocodeine, Hydromorphone, Norcodeine*, Oxycodone;
Oxymorphone. TOTAL OPIATES by GC/MS-Hydrolysis followed by OPIATES by GC/MS.
BENZODIAZEPINE CONFIRMATION by GC/MS: Alprazolam/ metabolite, Diazepam/ metabolites, Clonazepam, Lorazepam, Midazolam/metabolite, Triazolam.
17) SYMPATHOMIMETIC AMINES CONFIRMATION by GC/MS analysis (ng/mL): Amantadine, Amphetamine, beta-Phenethylamine, MDEA, Methamphetamine,
Methylenedioxyamphetamine (MDA), Methylenedioxymethamphetamine (MDMA), Phentermine, Phenylpropanolamine, Pseudoephedrine. GHB by GC/MS (mg/L): Gamma-hydroxybutyric acid (gamma hydroxybutyrate).
FENTANYL by GC/MS (ng/mL): Fentanyl, Sufentanil, Alfentanil.
20) SENT OUT TO REFERENCE LABS: Synthetic Cannabinoids and Synthetic Cathinones, Epinephrine, 7-amino Flunitrazepam, Flunitrazepam, IgE, Insulin, LSD,
Nefedipine, C-Peptide, Psilocin, Risperidone, Tryptase, Warfarin, Valproic Acid, HEAVY METAL SCREEN: (Antimony, Arsenic, Lead, Barium, Cadmium, Bismuth,
Mercury, Selenium) or any other drugs not listed above.
*BY REQUEST ONLY; ABBREVIATIONS: POS=Positive; NEG=Negative; UNS=Specimen unsuitable for testing; NTDN=Not Done; QNS=Quantity insufficient for
analysis; CHEM7=Clinical Chemistry; < =less than; > =greater than; LRL= Lower reporting limit; C.L. = Confidence Level.
UNITS FOR VOLATILES: 100 mg/dL≡ 0.100 g/dL ≡ 0.100 g/%. UNITS: 1 mg/L = 1000 µg/L = 1000 ng/mL.
Notification of Customers of Toxicology Capabilities

Source: http://medicalexaminer.cuyahogacounty.us/pdf_medicalexaminer/en-US/NotificationCustomersToxCapabilities.pdf