Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

Publik_bley

Publikationsverzeichnis

Originalarbeiten:

1.: Rob P.M., A. Lebeau, R. Nobiling, H. Schmid, N. Bley, K. Dick, I. Weigelt, J. Rohwer, Y. Göbel, K. Sack,
H.-G. Classen: Magnesium metabolism: Basic aspects and implications of cyclosporine toxicity in rats.
Nephron 72, 59-66 (1996).
2.: Bley N., K. Dick, P.M. Rob, K. Sack: Follow-up measurements of serum, lymphocyte and red blood cell
magnesium concentrations after renal transplantation and cyclosporin treatment with or without magnesium
supplementation. Magnesium Research, im Druck, (1996).
3.: Rob P.M., N. Bley, K. Dick, J. Rohwer, K. Sack: Magnesium deficiency after renal transplantation and
cyclosporine treatment despite normal serum-magnesium detected by a modified magnesium-loading-test.
Transplantation Proceedings 6, 3442-3443 (1995).
4.: Dick K., N. Bley, P.M. Rob, K. Sack: Magnesium deficiency after renal transplantation and cyclosporin
treatment despite normal serum-magnesium concentrations detected by a modified magnesium loading test.
Magnesium Research, im Druck, (1996).
Vorträge:

1.: Bley N., K. Dick, P.M. Rob, K. Sack: Follow-up measurements of serum, lymphocyte and red blood cell
magnesium concentrations after renal transplantation and cyclosporin treatment with or without magnesium
supplementation. 5th European Magnesium Congress, Wien, 15.-18. 6. 1995.
2.: Bley N., K. Dick, P.M. Rob, J. Rohwer, K. Sack: Verlaufsuntersuchungen der Magnesiumkonzentrationen
in Serum, Lymphozyten und Erythrozyten nach Nierentransplantation und Cyclosporinthearpie - mit und ohne
orale Magnesiumgabe. 17. Magnesium Symposium der Gesellschaft für Magnesium Forschung, Stuttgart, 29.-
30.9.1995.
Abstracts:

1.: Bley N., K. Dick, P.M. Rob, K. Sack: Follow-up measurements of serum, lymphocyte and red blood cell
magnesium concentrations after renal transplantation and cyclosporin treatment with or without magnesium
supplementation. Magnesium Research Vol. 8 Supplement 1, S. 13 (1995).
2.: Dick K., N. Bley, P.M. Rob, K. Sack: Magnesium deficiency after renal transplantation and Cyclosporin
treatment despite normal serum magnesium concentrations detected by a modified magnesium loading test.
Magnesium Research Vol. 8 Supplement 1, S. 22 (1995).
3.: Rob P.M., N. Bley, K. Dick, K. Sack: Magnesiummangel nach Nierentransplantation und
Ciclosporintherapie bei normalem Serummagnesium. Nieren- und Hochdruckkankheiten 24, 498 (1995).
Posterbeiträge:

1.: Rob P.M., N. Bley, K. Dick, R. Nobiling, K. Sack: Einfluß der Magnesiumzufuhr auf das
immunhistochemisch nachweisbare Renin, Natriurese und relatives Herzgewicht bei ciclosporinbehandelten
Ratten. Nordwestdeutsche Gesellschaft für Innere Medizin, 3.2.1995, Hamburg.
2.: Rob P.M., K. Dick, N. Bley, J. Vormann, T. Günther, K. Sack: Magnesium transport in erythrocytes of
patients under peritoneal dialysis compared to haemodialysis treatment. 7th Congress of the International
Society for Peritoneal Dialysis, 18. - 21-6-1995, Stockholm.

Source: http://www.krankenhaussoegel.de/pdf_files/allgemein/publik_bley.pdf

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