Material Safety Data Sheet
Methylprednisolone Sodium Succinate MSDS
Section 1: Chemical Product and Company Identification
Methylprednisolone Sodium Succinate
14025 Smith Rd.
US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA 8(b) inventory: No products were found.
CHEMTREC (24HR Emergency Telephone), call:
Solu-Medrol, Solu-Medrone, Urbason
solubile, MPS; 6-alpha-Methylprednisolone sodiumsuccinate; 11-beta-17,21-Trihydroxy-6-alpha-methyl-1,4-
International CHEMTREC, call:
pregnadiene-3,20-dione 21-(sodium succinate)
For non-emergency assistance, call:
succinate), monosodium salt
Section 2: Composition and Information on Ingredients
% by Weight
Toxicological Data on Ingredients:
Methylprednisolone Sodium Succinate: ORAL (LD50): Acute: >5000 mg/kg [Rat].
>5000 mg/kg [Mouse].
Section 3: Hazards Identification
Potential Acute Health Effects:
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to blood, spleen, gastrointestinal tract, adrenal,
bones, pancreas. Repeated or prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Section 5: Fire and Explosion Data
Flammability of the Product:
May be combustible at high temperature.
Products of Combustion:
These products are carbon oxides (CO, CO2). Some metallic oxides.
Fire Hazards in Presence of Various Substances:
Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.
Explosion Hazards in Presence of Various Substances:
Slightly explosive in presence of open flames and sparks. Non-explosive in presence of shocks.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards:
When heated to decomposition it emits acrid smoke and irritating fumes. As with most organic solids, fire is possible at
Special Remarks on Explosion Hazards:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion
Section 6: Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on
the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. If ingested, seek medical
advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in light-resistant
Section 8: Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
Section 9: Physical and Chemical Properties
Physical state and appearance:
Solid. (Powdered solid.)
pH (1% soln/water):
Water/Oil Dist. Coeff.:
Ionicity (in Water):
Section 10: Stability and Reactivity Data
The product is stable.
Conditions of Instability:
Excess heat, incompatible materials, dust generation
Incompatibility with various substances:
Reactive with oxidizing agents.
Special Remarks on Reactivity:
Sensitive to light.
Special Remarks on Corrosivity:
Will not occur.
Section 11: Toxicological Information
Routes of Entry:
Toxicity to Animals:
Acute oral toxicity (LD50): >5000 mg/kg [Mouse].
Chronic Effects on Humans:
May cause damage to the following organs: blood, spleen, gastrointestinal tract, adrenal,
Other Toxic Effects on Humans:
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals:
Special Remarks on Chronic Effects on Humans:
May cause adverse reproductive effects and birth defects (teratogenic)
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause
respiratory tract irritation. Ingestion: May cause nausea, and vomiting. May affect respiration, cardiovascular system, behavior/
central nervous system, blood, urinary system, spleen, hair, skin. Symptoms may include headache, increased intracranial
pressure, dizziness, seizures, insomnia, ataxia, restlessness, depression, anxiety, unusual moods, psychosis, euphoria,
personality changes, increased sweating, increased hair growth, reddened face, acne, thinned skin, easy bruising, tiny purple
skin spots, swollen feet, ankles, lower legs, muscle pain and weakness, stiffness, vision problems, puffy skin (especially
the face), general ateriolar or venous dilation, respiratiory depression, respiratory stimulation, chronic pulmonary edema,
cardiovascular arrythmias, cardiac arrest, congestive heart failure, hypotension, bradycardia . May also cause sodium and
fluid retention, hypokalemia, hypocalcemia, hyperglycemia, appetite stimulation or depression, increased susceptibility to
and masked symptoms of infection. Chronic Potential Health Effects: Ingestion: Prolonged or repeated ingestion may affect
urinary system, spleen(removal of old blood cells is dimished), adrenal gland (adrenal supression), blood (changes(decrease)
in white blood cell count, thrombocytopenia), immune system (supression of immune system), metabolism (weight loss or
weight gain), bones/joints (avascular necrosis, osteoporisis). May also cause ulceration or bleeding from the stomach or
duodenum, abdominal distention, ulcerative esophagitis, pancreatitis, allergic response (anaphylaxis), muscle weakness,
loss of muscle mass, Cushing's Syndrome, increased occular pressure and glaucoma, cataracts, exophthalmos, decreased
carbohydrate tolerance(glucose intolerance), manifestations of latent diabetes mellitus, increased requirements for insulin
or oral hypoglycemic agents in diabetes. Medical Conditions Aggravated by Exposure: There may an enhanced effect on
people with hypothyroidism, Diabetes, liver disease/cirrhosis. Also, existing emotional instability or psychotic tendencies
may be aggravated by corticosteroids. If there is a probability of impending perforation, abscess, or other pygenic infection;
diverticulitis; fresh, intestinal anastomoses, active or latent peptic ulcer; renal insufficiency; hypertension, osteoporosis,
Section 12: Ecological Information
BOD5 and COD:
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity of the Products of Biodegradation:
The product itself and its products of degradation are not toxic.
Special Remarks on the Products of Biodegradation:
Section 13: Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Section 14: Transport Information
Not a DOT controlled material (United States).
Special Provisions for Transport:
Section 15: Other Regulatory Information
Federal and State Regulations:
No products were found.
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the
European Inventory of Existing Commercial Chemical Substances.
Not controlled under WHMIS (Canada).
Not Available Not applicable.
National Fire Protection Association (U.S.A.):
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.
Section 16: Other Information
Other Special Considerations:
10/10/2005 12:45 AM
11/06/2008 12:00 PM
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Mr Scott R. Hepburn MB, ChB, BSc(Hons)MedSci, FRCSEd(A&E), FCEM, FIMC, RCSEd, DipFMS Consultant in Emergency Medicine Department of Emergency Medicine Western Infirmary Dumbarton Road Telephone: 0141-211 2731 Fax: 0141-211 6303 (secretary) REPORT FRONT SHEET MB, ChB, BSc(Hons)MedSci, FRCSEd(A&E), FCEM, FIMC, RCSEd, DipFMS Consultant in Emergency Medicin