Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.
Gralton.net
Is this really that neccesary to get a PE/teaching degree? Kines is a bit over the top in my opinion, here's my notes for ONE lecture, yeah you probably won't understand my writing, that's OK. I don't really either. Lecture Notes- Kines-neurobasis of human motion--- Central Nervous System- Brain, Spinal Cord Peripheral Nervous System Afferent (System) goes to CNS Afferent tells CNS whats going on, efferent does what it needs to do, effector organs Efferent away from CNS -Somatic Nervous System (CNS skeletal muscles) -Autonomic Nervous System ( CNS heart muscle, smooth muscle) 3 basic functions of heart and nervous system: Excitability- receptor has been activated, stimulated to the point of action Conduction- once receptor is stimulated signals are conveyed to or away from the CNS REFLEX ARC- ? Neurons- Sensory to the CNS- afferent comes in interacts connector neuron, sends out an action to the body Receptors to the CNS, to the spinal cord—dendrites conveying information to the cell body to soma, peripheral nerve conveys info to that region, to the axon. Motor-efferent away from CNS Connector-enuncial? Found specifically in the spinal cord. Serve as a link between sensory and motor Dendrites- direct neurological signal/impulses toward the cell body, pick up sensory info and conveys it to soma, cell body of cell, once is receives info it sends it out the axon- signal proceeds away from dendrite to the axon. Axon- core structure, may or may not have myolin sheath, depending on location, where central or peripheral in nature, myolin shealth is an insulatory covering of that nerve fiber. Like the plastic coating on a copper wire. If a nerve fiber has a myolin coating/sheath it is termed a medulated fiber. If it does not have a myolin sheath- its termed NON-medulated fiber. Like a jelly roll (myolin sheath is outside) MEDULATED FIBER? Myolin Sheath- mostly protein, and medulated fat, fatty material to add an insulated coating. Each one of these units- is called a SCHWANN CELL? Node of Ranvier- gaps in the …allows signal or impulses from point to point, which increases conduction velocity, the process in which a signal jumps from point to point is termed ___something___ conduction. Nodes like Fast twitch fibels- signal to it as quick as possible so it gets contraction fast, gets from point A to B as quick as possible. Signals in place to help that— do it quickly, effectively and faster. Saltatory? Conduction- is what is above Terminal Branch- (synaptic vesicles, nerve transmitters) Nerve fiber is close proximity to the muscle tissue, fingerlike projections (goal: motor neurons cns to affector organ like a muscle or gland, perpetuate a response if the signal is strong enough. Brain- Cerebrum- cerebral cortex (cortex outer covering) JUDGEMENT Sensory, Motor, Pre/Motor- sensory area focuses on interpretation of information coming to the brain, so that you can initiate the appropriate action. Motor- deals with development-fine motor movement, learns motor skills, hands, feet, toes, lips, etc. to facilitate appropriate activity. Progression and skill development Pre-Motor-progression of skill development, primary motor center, start to learn skill motor movement, primary motor unit- progression in motor development. Baby Learning to Walk --> progress to solid movement Cerebral (cerebrum?) -judgment (walking down sidewalk, carefully look at ground) Thalamus- rerun center, relay system. efferent/afferent fibers coming in impulses coming in conveyed to central cortex; determine degree of alertness, how well you sleep, how to relax level of consciousness, etc. taking in and trying to regulate all efferent/afferent material. analogy: train station- move turnstop- train keeps going but moves to a different track. ALL THIS IS REFLEX ARC: Cerebellum- refinement of movement/movement patterns, blow to the back of the head- you lose refinement of movement, your uncordinated for a while. Brain Stem- Area of Inhibition, Pons, Medulla, regulate body temperture, respitory patterns, involintary control, holding your breath-you start again. Spinal Cord- Transmits signals to the brain, [sensory/motor] information relayed to and from the brain, part of the CNS. Spinal Nerve- come in from a lateral perspective; subsection of entire nervous system, vetebral column, dens, opening is vetebral foramen, spinal cord in encased in foramen (opening hole), between vetebre/gaps- inteveterbral foramen, out of that comes out Spinal Nerve, come out laterally-left and right sides/both sides of body. Spinal nerve bifercates-splits into 2 structures, fibers run both posterior and anterior, dorsal (posterior)- take both sensory (afferent) and motor, goes in posteriorally-sensory. (EnterAuncial) Connector Neuron link between sensory anteriorally/front/ventral- motor (efferent) -Cable Line: Kind of like your spinal nerve,(fiber optics) bifercates/splits-spina, sensory and motor both coming out, tracks of information. Spinal Nerve --> goes to specifically the skeletal muscle fibers/tissue are part of the ALPHA MOTOR SYSTEM (60% of motor/40% sensory) body has more sensory, fibers that are sensory to a 3-1 ratio. sensory has to relay information to get appropriate response out. Example of alpha motor system: biceps brachi, tricep brachi GAMMA MOTOR SYSTEM- directly linked to receptors, like muscle spindles that help judge responses to stimulations. synapse: junction between nerve, or a nerve/nerve, muscle, neuromusclar junction/myonueral junction - ?research? no union between nerve/tissue-its a gap called a synaptic cleft, no physical contact, always unidrectional- only goes one way (like going down to Atlanta, one way roads) Glycolosis: Biodirectional, produce stuff and then synathsise it, produce Acetyl Coa- everything from that point is unidirectional. Once you got dentrite, soma, its only going one way. Terminal Branches of Nerve Fiber- Mitochondria, Synaptic Vesicles, Transmitters, if your not using an area you may lose sensativity to the chemical stimulus, its like drinking coffee- if you are used to drinking coffee your not going to get the buzz, threshold is higher. If your using the muscle, neuromusclar system- if you use it regularly chemically its going to stay at a higher state of rediness to be called upon, muscle tissue requires neuromuscular activation. Conduction velocity- increases with a decrease number in synapes, and decreases with a higher number of synapses, inverse relationship. Variety of nerve cells- no physical connection gap between nerve cells (somas, axons), chemical action stimilates this, chemical boom, chemical boom, every synapse you have requires a stimulation of tissue, the more synapses you have the slower the process is going to take (from point A-B) like going through a town with a bunch of traffic lights.Reflex receptors touch on later, very few synapses. Action Potentials- happens neurologically, chemically, positive or negative, exhitatory or inhibatory- after you sit down a while, it hurts, lots of inpulses coming in, Know where muscles lie Know relationship between muscles joints Slow twitch- endurance, more slow twitch in posture groups (keep you sitting up) Fast twitch- quick movements -focus in on action, what the muscles do. Type of joint, muscles line of pull in relationship to the joint/structure. Body is not robotic, its fluid-dynamic. What is difference between appendicular and axial? QUIZ 4- Exclusively shoulder joint and shoulder girdle Foundational base SHOULDER SJ/SGPectoral Based Region- Bones make up [SG Clavicle, scapula] [SJ- Humerus Based Action]Shoulder Girdle:Clavicle, ScapulaJoints Associated: Junction between clavicle/sternum (xiphod process, menuvrum)*Main Joint: Sternoclavicular Joint – sole connection between upper extremity and axial SkeltonSole connection from axial to appendicular system is the STERNOCLAVICULAR JOINT.Other Joint of concern is AC JOINT (Acromioclavicular)Coricoid Process, Ribs over scapula, acromium2 Principle Joints of SG Region- Sternoclavicular (sole connection) and AC Joint.Shoulder Joint itself is GLENOHUMERAL JOINT.Most joints are named based on name of body structure, you know humerus- the depression is glenoid cavity/glenoid fossa. GLENOHUMERAL- you can identify most joints bone name/structure. When im talking shoulder joint-humerus/scapularShoulder Girdle-clavicle and particularly scapula based actionSterno-Clavicular Joint 5 movementsScapular Based Action 8 movementsShoulder Joint 13 movements (26 movements in those areas)Shoulder Joint- Glenohumeral joint ball and socket, degrees of freedom = 3, DOF- strength number of planesGlenoid Fossa/Glenoid Cavity – Head of humerus comes in like this…Glen Hum Joint- Has hyaline cartildge, hyaline cartilage is weakest cartilage and most abundant, there to protect joints/bony structures, also have distinctive area of fibero cartilidge, white fibrocartidge that lines the structure, called the glenoid labrum, its kind of like a cornpad- encompassing this region- depth of fossa? Shallow. Ball and socket joint (shoulder-most susceptible to dislocation) very shallow socket, not deep susceptible to dislocation, to secure head of bony structure (humerus or femur) like the lip of a big frying pan- white fiber cartridge, it is very strong.Without that susceptible to dislocation, without supportive structure (tendons, muscles-provide greatest prohibitive element with injury) don’t build it up- football player gets tackled. Lands on elbow, elbow accepts force to humerus, head of humerus absorbs force, protrudes that way towards anterior/superior, tears up laberal based region.2 Specific functions for glenoid labrum1-deepens fossa. Creates a stable situation, so its more likely to help itself adds more stability.2-cushions against impact forces, general characteristic of all cartilaginous material, cartilage is there to help absorb impact forces.Ligamentous Support-*Corocoid Humeral unit of lig material that comes from corocoid process or medial portion of head of humerusstructure: Corocoid Process, Acromial Based Unit, Glen Fossa Cavity*Coroco acromial ligament- corocoid to acromium, doesnt directly attach to humerus, aids in the stability of structure.from the standpoint of rotorcuff muscles (major rototator cuff muscle-superspinatus goes right underneath this structure)glenohumeral, corocohumeral, corocoacromiallabrum adds support structurally and more stability for impact forces, ligaments hold head of humerus in.-corocohumeral, corocacromial, glenohumeral (important)-ball and socket, encased in a capsule (diathrosis joints)Rotator Cuff Muscles: S.I.T.S (Superspinatus, Infraspiatus (posterior), Teres-Minor(posterior), Subscapularies(ant/sup))Super means: ABOVE, superspinatus is superiorScapula has (4) fossas:glenoid fossa, superspinus fossa, subscapular fossa (aneriorally), infraspinus fossa (posteriorally)muscles line those regions, superiorly-super, infra-postirior, superspinus-anteriorallyLOOKING AT JOINTS-STRUCURE: GLENOID FOSSA, LIGAMENT, laberal material, muscle support (this is structural understand. of the joint)MOVEMENTS: 13 MOVEMENTS OF THE SHOULDER JOINT- FROM VARIETY DIFF PLANES ACTIONSFLEX/EXT WORK: SAGITALADDUCTION FRONTAL, TRANSERVE WORK: ROTATION, rotary-HORIZONT AB (exten)/AD (flexion), OBLIQUE (diag plane mvmnts) MOVEMENTSHYPER MEANS- FULL RANGE OF MOTION.Ball and socket joints: original dyathrosis joints- these are the basic movements produces in a ball and socket j flex/ext/adduction/abduction/circum/rotation – now looking at it in a more specific manner.Arm pushing at a wall- bring humerus up- flexion, bring it back-extension (extreme ROM hyperflexion/hyperextension)Frontal plane-movement toward midline of body adduction/abductionCircumduction- cone shaped movement, extension/abduction/flexion/adduction (sequential based movement)Ad/ab what you would see with a peck deck- arms up, bringing it across, watch the forearm, arm coming across staying horizontal/transverse pulled forward-horz aduction/flexion back-horz abduction/extension. Barbell- hands shoulder w apart- movement at shoulder joint-flexion, down-extension at shoulder joint- barbell out further toward the bar out-horizontal aduction/flexion. Change role of muscle, change role of muscle prod.Diagonal movements- throwing, cocking phase, diagonal abduction, excel phase-across body-diagonal aductionRotation- arm from anatomical perspective, arm totally straight then do this-inward/medial rotation, or outward/lateral rotation, bend at elbow bring arm inward-inward/medial, out-outward/lateral, upward out like this- inward medial, cocking phase-outward/lateral. Change limb in space and still replicate a movement.Illustration- like a bench press- if you cant identify what name of movement is with movements you observe, how can you match it up with the muscle and what its doing, identify matchup movement, name of movement, and muscle that produces that movement.Compartmentalize it, systemize it, compartmentilization – see it a lot in all of the joint, 80 percent of the material. Shoulder joint- 4 compartments (look at anterior/superior, posterior/inferior)Typically- sheets will break down muscles and compartiments,Anterior compartments- 3 movements associated- flexion, adduction, inward rotationAnterior muscles- in general pectoralis most prevalent, anterior muscles of chest-pull forward-flexion, midline-addiction, inward rotation.POSTERIOR: extension/outward rotation. Infraspinatus/teres minor (associated with rotator cuff muscles)Posterior means back of scapula, coming across attaching to humerus, post to shoul joint, contract- pull arm back-extension, hyperextension, bc of outward pulling effect, outward pulling rotation.Superior compartment-above shoulder joint, ABDUCTION, elevation is reserved for shoulder girdle. Pulls upINFERIOR- long head of tri brachi, lat dorsi, opposite to anterior, except theres extension- exten, adduction, inward rotation.WHAT MOVEMENT IS (ADDUCTION) , MUSCLES PULL, MUSCLES HAVE TO BE SUPERIOR, SUPERIOR COMPARTMENT- MUSCLES OF THAT COMPARTMENT, DELTOID/SUPRASPINATUS.This is movement, what compartments produce this movement, what muscles are in that compartment.-TYPE OF JOINT (Shoulder Joint-Ball and Socket) 13 movements, Movements possible? Flexion, extension, abduction, adduction, circumduction, rotation-medial/lateral, what is movement produced? ID the muscles that do it.-Bench Press, pushing weight away from body, flexion, anterior, muscles: pec major, coracobrachialis, subscapularis, biceps brachii.-Cable System- pulley, extension, posterior muscles, infraspinatus, LATS are biggest. Muscle mass translates to strength. Develop lats, posterior/inferior compartments. If your systematic it flows.
ESTRADIOL ------------------------------------------------------------------------------------------------------------------------------------------------------ HAZARD SUMMARY WORKPLACE EXPOSURE LIMITS Estradiol can affect you when breathed in and by passing No occupational exposure limits have been established for Estradiol . This does not mean that this substance is not Contact
When I take Benadryl for my allergies, the heavy-eyelid,sleepytime feeling I get reminds me of lying in a sleep-ing bag during slumber parties while dozing off betweenscreams and shrieks of girls being shredded by FreddyKruger in Nightmare On Elm Street , and girlfriends gos-siping about boys at school. Benadryl produces the sen-sation of being asleep and being awake simultneously,like being insu