Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

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Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2010 Capri-Sonne STILLS
2010 Capri-sonne
2009 Becel
Mark Upton / Filip Vangeffele Patrick Van Hautem 2008 B95 Film
Emmanuel Coste / Alexandr Stephane Leloutre 2006 Quelle Stills
2002 Djarum
2002 Opel
2000 Dior
Aram Kevorkian / Olivier Tha Erick Ifergan Music Video
2002 Lighthouse Family
2001 Electric Soft Parade
Bernd Possardt / Jeffr Wardrobe Assistant Features
2012 Bordering Bad Behaviour
2012 The Perfect Wave
Divine Inspiration ( Divine Insp David Selvan / Bryan Hickox Bruce MacDonald 2012 Where the Road Runs Out DO Productions (Pty) Ltd
Marlow de Mardt / Brigid Ole Rudolf Buitendach 2011 Flight of the Storks
2008 The Ambassador
Giselher Venzke / Bertha Spi Sigi Rothemund 2008 Amelia
Moonlighting Amelia Films(Pty Don Carmody 2007 Riemvasmaak
2007 Rendition
Rendition Avery Pix, Inc / Moo Marcus Viscidi 2006 Rainbow Warrior - Secret A Eagle Films
Bernard Bouix / Thierry Cass Charlotte Brandstorm Wardrobe Supervisor 2005 Follow Your Heart
2004 Tsotsi - OSCAR WINNER
2003 Out on a Limb
2003 Forgiveness
2003 Little Man
2001 The Piano Player
1998 Chase The Wind
Corporate Video
2007 Astra Zeneca
Commercial - International
2013 Calve
2013 Leclerc
Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2012 Juice Films - Tom Tom
2012 McDonalds
2012 Nestle
2012 C&A "Studio"
2012 C&A 'Hot week''
Jon Day / Helmut Hartl / Alex Thomas Wommelsdor Wardrobe Stylist 2012 Sony
2011 Reckitt Benckiser '' Mucine Dancing Light Production
2011 Momentum
2011 Cell C
2011 Caprisonne Magic Straw
2011 Walkers
2011 B&Q
2011 Joyvale
2011 Hermes
2011 Sigma
2011 Party Poker
Karin Tanchel / Serena Pros Richard Oliver 2011 Truck Mom Postponement Cinergy (Cape)
2011 Caprisonne Truck Mom We Cinergy (Cape)
2010 Budweiser
Peter Sherlock / Trudy Turne Chris Nelson 2010 Capri-Sonne "Friendship" Cinergy (Cape)
2010 Nutrilon
2010 Capri-sonne
2010 Telecom
2010 Trident
2010 Loka
Vivian Esterhuyse / Therese Bjorn Stein / Mans Ma Wardrobe Assistant 2010 Come A Casa
2010 FBTO
Mandy Ritchie / Toni Marais / Nic Osborne / Sune M Wardrobe 2010 Stihl
Mandy Ritchie / Andi Schnei Jens Schneider 2010 VW Polo
2010 Caprisonne
2010 Lucozade
Skip Margetts / Nadine Brow Stacy Peralta 2010 Scotts
2009 Coop
2009 C & A 8th Flight
Jon Day / Alex Fishcher-Budi Moritz Laube 2009 Santander
Peter Sherlock / Richard Pac Philippe Andre 2009 Thomas Cook
2009 Fruit Snacks
Peter Sherlock / Alice Grant Guy Manwaring 2009 Senseo
Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2009 Capri " Lotto"
2009 Capri "Lars Bond "
2009 Thuraya
E Z Trade 678 cc t/a Jungle Fi Lawrence Goodman / Leigh Jac Mulder 2009 Tombola
2009 Wina Manje Weatherday
2009 Wina Manje
Lorraine Smit / Amy Dawson Jerome Pikwane 2009 Polo
David Elton / Aleksandra Glo Sune Maroni / Nic Os Wardrobe 2009 Engen
2009 Brico
2009 Surf
2009 Pearle
Mandy Ritchie / Francois Me Floris Kingma 2009 Jillz
2009 Simple
2008 C & A
2008 Royal Mail
2008 Mercedes
2008 US Cellular
2008 Resolva
2008 Ackermans Winter
Sonja ter Horst / Linda Notel Sheila Kubheka 2008 C & A 47 Flight
2008 Littlewoods
2008 C & A 46 Flight
Mandy Ritchie / Micha Schmi Tony Esslinger 2007 Walkers
2007 Natura
2007 Sasko
2007 Opel "kite"
Mark Upton / Constance Guil Michel Guimbard 2007 Tetley
Helmke Moller / Richard Edh Henrick Lagercrantz 2007 Oral B Experts
2007 Nouwens
Linda Notelovitz Goodall / So Miles Goodall 2007 Web Monkeys
2007 C & A 41st Flight
2007 Hummer (Big Sky)
2007 Sandoz
Liz Bullen / Natalia Strzalkow Lukasz Zadrzynski 2007 C & A 40th Flight
Mandy Ritchie / Alex Fischer Christopher Roth 2007 Bradford & Bingley
2007 Delta Lloyd 2
Kerstin Kambier / Meike Lae Yani Verschuuren Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2006 Quelle
Beverley Green / Kate Taylor Mehdi Norowzian Phil Contomichalos / Jean Vi Sebastian Chantrel 2006 Contessa
2006 ESSO
Beverley Green / Alice Grant Guy Manwaring 2006 Mazda
2006 City Lodge
2006 ABN Amro
Debbie Cornell / Carine Harri Steven Diller 2006 Rama
Meike Laesch / Frank Siegl / Kasper Barfoed 2006 Snack A Jax
2006 San Diego Zoo
2006 C&A 35th Flight
2006 Bavaria
2006 C&A 34th Flight
Cindy Rodkin / Alexandra Fis Tony Esslinger 2006 Pagine Bianche 12:40
Anton Rollino / Cristina Davi Francesco Nencini 2006 12.40 Vigniettes
Anton Rollino / Valter Buccci Francesco Nencini 2005 Calanda
2005 Swiss Lotto
2005 Guiness
2005 12.40
Anton Rollino / Angus McDo Francesco Nencini 2005 Pay Less
2005 Black & Decker
2005 Microsoft Biral
2005 Detrol
Anton Rollino / Kare Godsell Jonathan Teplitzky 2005 Black and Decker
2005 Nivea Visage
2005 Avodart
2005 Vodaphone
Janette De Villiers / Matthew Michael Chaves 2005 Coca Cola "Peace Ball"
2005 C&A 27th Flight
Mandy Ritchie / Cindy Rodki Stefan Telegdy / Mark Wardrobe 2005 Air Miles
2005 Copella
2004 DE - Douwe Egberts
2004 Opel Astra ''18th Birthday'' MIA Films
Phil Cintomichalos / Rudi Ro Calle Astrand 2004 Reminyl Galantamine
Libbi Ball / Jonathan Ker / Gr Raymond Bark 2004 Almette
2004 Diet Coke
Martin Jacobson / Toby Cour Henrik Sundgren 2004 Mtv/ Venus Competition Sp Filmworks Africa
Carole Prentice / Leighton C Katie Dawson 2004 Kelloggs
Saskia Finlayson / Glen Bos Bernd Possardt / Jeffr Wardrobe Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2004 Mercedes
Adam Lyne / Debbie Turner Nicolai Fugslig 2004 C & A 21st Flight
Mandy Ritchie / Helmut Hartl Thomas Wommelsdor Wardrobe Assistant 2004 Tchibo 2
Moonlighting Film Production Helmke Moller / Nina Jutting Matthaus Bussman 2004 Tchibo
Moonlighting Film Production Helmke Moller / Hannes Buh John Tonic 2004 Cubus 3
Moonlighting Film Production Helmke Moller / Espen Horn Sune Maroni / Nic Os Wardrobe Assistant 2003 Thomapyrin
Alexander Muller-Elsner / Jo Michael Kaden 2003 Cubus
Moonlighting Film Production Helmke Moller / Irene Sodal Nic Osborne / Sune M Wardrobe Assistant 2003 Women's Work
Nicola Corte / Susannah She Aasaf Ainapore 2003 Aqua Minerale
Andrejz Slzek / Dimitri Dobu Greg Francis 2003 Meteor
Mandy Ritchie / Russ Russel Dominic Murgla 2003 Olej
Andrejz Slazek / Jarek Pogor Marcin Ziebinski 2003 4 x 4 Peugeot
Emmanuel Coste / AlexanDe Carl Bouteiller Moonlighting Film Production Beth Tomlinson / Martin Jac Olivier Venturini 2003 Frosta
Tina Reunert / Meike Laesch Shizue Dahmen 2002 Almhof
Mandy Ritchie / Stephanie D Kees Dijkstra 2002 Hutchinson
Niki Hall-Jones / Lesley Redr Trevor Melvin 2002 Valtrex
Bernd Possardt / Jeffr Wardrobe Assistant 2002 Skippy Jar
2002 Landrover
Bernd Possardt / Jeffr Wardrobe Assistant 2002 Djarum
Bernd Possardt / Jeffr Wardrobe Assistant 2002 Oppenheimerfunds
2002 Lutosa '' Aristide''
Gaye Leong / Eva Custers / Frank Papenbrock Br Wardrobe Assistant 2002 Greene King
Bernd Possardt / Jeffr Wardrobe Assistant 2002 Labatte Blue
Bernd Possardt / Jeffr Wardrobe Assistant 2002 Fanta Campervan
David Elton / Juli Lotter / Sla Bruce Parramore 2002 Nurofen Plus
Anton Rollino / Rigby Andre Christophe Williams 2002 Cheese String
Bernd Possardt / Jeffr Wardrobe Assistant 2002 LG 2002
Martin Jacobson / Bruce Mill Dietrich Mangold 2001 Garnier Fructis
2001 Opel Corsa
Roy Basil Zetisky / Fintan Gs Lourens Van Rensbur Standby Wardrobe Noel Senogles / Farid Haikal Thierry Duperty 2000 Frutella
2000 Nestea
Beverly Green / Tara Handle Kevin Donovan 2000 Bizzl Zwerge
Bernd Possardt / Jeffr Wardrobe Assistant 2000 Yves Rocher
2000 Signum
McKenzie Rudolphe Film Serv Ken McKenzie / Roy Rudolp Michael Seresin 2000 Exotica
Emmanuel Coste / Mona Ma Jean Paul Sealieu 2000 Passion
Cindy Viljoen / Irena Skorze Michal Sablinski Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2000 Sunny 2
Marco Mazzei / Chris Lo Stephanie Morland 2000 Fanta
Bernd Possardt / Jeffr Wardrobe Assistant 2000 Devk
Meike Laesch / Barbara Kra Caspar-Jan Hogerzeil Wardrobe Assistant 2000 Siemens
David Elton / Wynton Tavill / Thorston Harms 1999 Arby's
1999 Swatch
Anya Klages / Richard Rona Paolo Calcagni 1999 Russell Athletics
1998 Meggle Butter
1998 Coca Cola
Bernd Possardt / Jeffr Wardrobe Assistant 1998 GoodYear Tyres
McKenzie Rudolphe Film Serv Ken McKenzie / Roy Rudolp Daniele Cosentino 1998 Accept Card
Bernd Possardt / Jeffr Wardrobe Assistant 1998 Ericsson CE-Bit
Bernd Possardt / Jeffr Wardrobe Assistant Commercial - Local
2010 Engen
2010 Peak Talent Show
2010 Carling
2009 Fruit Tree
2008 Caprisonne birthday
2007 Micatex
2007 Sanlam
2005 Tura
2005 Cadbury's
2005 Sanex
The Picture House Film & TV Barbara Snell 2005 Vodacom Rugby
2005 Royco
2005 Momentum Corporate
2004 AF/MZ Pitch
2004 Windhoek
2004 Toyota Hilux
2004 Telkom Danny Jordaan
2004 Telkom 1
2004 Isuzu
2003 Esprit
2003 Guinness
Brian Critchfield / Gavin Gille Eli Sverdlov 2002 Djarum
2002 FNB Cheque Account
Jenny Leslie / Chris McCann Jeremy Goodall 2002 Lotto
Curriculum Vitae -Gillian Castle
Production House
Producers
Directors
Position
Director of Photography Head of Department
2002 Eskom S.O.S
2002 Markhams
Jenny Leslie / Chris McCann Jeremy Goodall 2001 Toyota Corolla
Bernd Possardt / Jeffr Wardrobe Assistant 2012 Strongbow March
2010 Capri-Sonne "Truck Mom Cinergy (Cape)

Source: http://www.gilliancastle.com/Gillian_Castle_Resume.pdf