Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

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Tables
Components of Per Member Per Year Cost Trend 1997-2002 Utilization of Common Drugs for the Top 25 Therapy Classes 2001-2002 Price Changes Due to Inflation for the Top 25 Therapy Classes 2001-2002 Price Changes for the Top 50 Common Brand Drugs 2001-2002 Price Changes Due to Therapeutic Mix for the Top 25 Therapy Brand/Generic Mix for the Top 25 Therapy Classes 2001-2002 Changes in Units Per Prescription for the Top 25 Therapy Percent of 2002 Ingredient Cost and Cost Per Prescription for the Table 10:
Top 10 Therapy Classes Contributing to 2002 Trend Table 11:
2001-2002 Summary and 2003-2007 Forecast for Major Therapy Classes Table 12:
Table A1:
Cost Per Prescription and PMPY Cost for Major Therapy Table B1:
Total Medicaid Prescription Cost 1996-2001 Table B2:
PMPM Medicaid Prescription Drug Use 1996-2001 Table B3:
Figures
Figure 1:
National Health Expenditures for Selected Healthcare Accounts Figure 2:
2002 Generic Conversion Rates for Glucophage® to Metformin and Market Figure 3:
2002 Generic Conversion Rates for Zestril®/Prinivil® to Lisinopril andPrinzide®/Zestoretic to Lisinopril/HCTZ and Market Share for Zestril®/Prinivil®, Prinzide®/Zestoretic, Lisinopril and Lisinopril/HCTZ Figure 4:
U.S. Sales for Brand Products With Patent Expirations Between2003 and 2007 Figure 5:
Generic Fill Rate Fourth Quarter 1994 to Fourth Quarter 2007 (Estimated) Figure 6:
Percent Change in Ingredient Cost Per Prescription Due to Inflation, Therapeutic Mix, Brand/Generic Mix and Units 2001-2002 Figure 7:
Impact of New Drugs Introduced Since 1992 on 2002 Utilization and Figure 8:
Percent of Ingredient Cost Accounted for by New Drugs Introduced Since 1992 Figure 9:
Percent Changes in Ingredient Cost 1996-1997 to 2006-2007 Figure 10:
Figure 11:
Continuum of Approaches to Maximizing Generic Opportunities E x p r e s s S c r i p t s , I n c .
Figure A1:
Therapy Class Drug Market Share Trend — Gastrointestinals Figure A2:
Therapy Class Drug Market Share Trend — Antidepressants Figure A3:
Therapy Class Drug Market Share Trend — Antianxiety Agents Figure A4:
Therapy Class Drug Market Share Trend — Antipsychotics Figure A5:
Therapy Class Drug Market Share Trend — Anti-Rheum (NSAIDs) Figure A6:
Therapy Class Drug Market Share Trend — Narcotic Analgesics Figure A7:
Therapy Class Drug Market Share Trend — Migraine Products Figure A8:
Therapy Class Drug Market Share Trend — Anticonvulsants Figure A9:
Therapy Class Drug Market Share Trend — Antihypertensives Figure A10:
Therapy Class Drug Market Share Trend — Calcium Blockers Figure A11:
Therapy Class Drug Market Share Trend — Beta Blockers Figure A12:
Therapy Class Drug Market Share Trend — Antihyperlipidemics Figure A13:
Therapy Class Drug Market Share Trend — Antiasthmatics Figure A14:
Therapy Class Drug Market Share Trend — Antihistamines Figure A15:
Therapy Class Drug Market Share Trend — Decongestants/Nasal Steroids Figure A16:
Therapy Class Drug Market Share Trend — Cough/Cold Figure A17:
Therapy Class Drug Market Share Trend — Cephalosporins Figure A18:
Therapy Class Drug Market Share Trend — Macrolides Figure A19:
Therapy Class Drug Market Share Trend — Penicillins Figure A20:
Therapy Class Drug Market Share Trend — Quinolones Figure A21:
Therapy Class Drug Market Share Trend — Antivirals Figure A22:
Therapy Class Drug Market Share Trend — Oral Contraceptives Figure A23:
Therapy Class Drug Market Share Trend — Estrogens Figure A24:
Therapy Class Drug Market Share Trend — Miscellaneous Endocrines Figure A25:
Therapy Class Drug Market Share Trend — Dermatologicals Figure A26:
Therapy Class Drug Market Share Trend — Oral Antidiabetics Figure A27:
Therapy Class Drug Market Share Trend — Insulins Figure A28:
Therapy Class Drug Market Share Trend — Anticancer Figure B1:
Figure B2:
Growth of Enrollment in Medicaid Managed Care Programs by Percent of Recipients 1991-2001 Figure B3:
Medicaid Spending as a Percent of Health Spending 1998 Figure B4:
Growth Rates in Each Type of Expenditure 1998-2000 Figure B5:
Total Medicaid Prescription Drug Costs vs. Number of Enrollees 1996-2001 Figure B6:
Medicaid PMPM Utilization vs. Cost Per Rx 1996-2001 p t s , I n c .
2 0 0 2 D r u g Tr e n d R e p o r t

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