Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.
Chpw.org2
Pharmacy and Therapeutics Committee Decisions March 19, 2010 Drug/Therapeutic Class P&T Decision Bepreve® (bepotastine besilate ophthalmic solution) • Non-formulary Medications
– Treatment of Allergic Conjunctivitis Effient® (prasugrel) – Platelet Aggregation Inhibitor • Formulary Multaq® (dronedarone) – Treatment of Arrhythmias • Non-formulary Sabril® (vigabatrin) – Treatment of Seizures and
• Formulary with Prior Authorization Samsca® (tolvaptan) – Treatment of Hyponatremia
• Formulary with Prior Authorization Votrient® (pazopanib) – Treatment of Renal Cell
• Formulary with Prior Authorization Therapeutic Acne Vulgaris
• Formulary: benzoyl peroxide,
Acanya® (benzoyl peroxide/clindamycin), Aczone®
(dapsone), Avita® (tretinoin), Azelex® (azelaic
peroxide/erythromycin), benzoyl peroxide, benzoyl
peroxide/erythromycin, clindamycin topical,
• Non-formulary: Acanya, Aczone,
peroxide/clindamycin), Epiduo® (adapalene/benzoyl
peroxide), erythromycin topical, Retin-A® Micro
(tretinoin), sulfacetamide, Tazorac® (tazarotene),
tretinoin, Ziana® (clindamycin/tretinoin)
Gel, Duac, Epiduo, Retin-A Micro, Tazorac, Ziana
Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
• Non-formulary: Janumet, Januvia,
Janumet® (sitagliptin phosphate/metformin),
Januvia® (sitagliptin phosphate), Onglyza® (saxagliptin) Central Nervous System Stimulants
• Formulary: amphetamine/
amphetamine/dextroamphetamine, amphetamine/
(methylphenidate ER), Daytrana® (methylphenidate
dextroamphetamine, dextroamphetamine SR,
Focalin® XR (dexmethylphenidate ER), Intuniv®
(guanfacine ER), Metadate® CD (methylphenidate
ER), Metadate® ER (methylphenidate ER),
• Non-formulary: Daytrana,
methamphetamine, Methylin® (methylphenidate),
methylphenidate, methylphenidate ER, Ritalin® LA
(methylphenidate SR), Strattera® (atomoxetine),
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Drug/Therapeutic Class P&T Decision
Vyvanse® (lisdexamfetamine) Fibromyalgia Agents
• Formulary: Cymbalta (prior auth)
Cymbalta® (duloxetine), Lyrica® (pregabalin),
• Non-formulary: Lyrica, Savella
Savella® (milnacipran) Pulmonary Arterial Hypertension
• Formulary: Adcirca (prior auth),
Adcirca® (tadalafil), Letairis® (ambrisentan),
Revatio® (sildenafil citrate), Tracleer® (bosentan),
Tyvaso® (treprostinil inhalation), Ventavis®
• Non-formulary: Tyvaso, Ventavis
(iloprost inhalation) Atypical Antipsychotics
• Formulary: Abilify (step therapy 2nd
Abilify®/Abilify® Discmelt/Abilify® Solution
(aripiprazole), Fanapt® (iloperidone), Geodon®
(ziprasidone), Invega® (paliperidone), risperidone,
risperidone orally disintegrating, risperidone
solution , Saphris® (asenapine), Seroquel®
(quetiapine), Seroquel® XR (quetiapine extended-
release), Symbyax® (olanzapine/fluoxetine),
• Non-formulary: Abilify Discmelt,
Abilify Solution, Fanapt, Geodon, Invega, Saphris, Symbyax, Zyprexa Zydis
Bowel Evacuants
• Formulary: NuLytely, Nulytely
Colyte® with Flavor Packets, GoLytely®, Half-
Lytely-Bisacodyl® with Flavor Packs, MoviPrep®,
• Non-formulary: Colyte with Flavor
NuLytely®, Nulytely® with Flavor Packs, PEG-
Bisacodyl with Flavor Packs, MoviPrep, TriLyte with Flavor Packs
Leukotriene Pathway Inhibitors
• Formulary: Singulair (step therapy)
Accolate® (zafirlukast), Singulair® (montelukast),
• Non-formulary: Accolate, Zyflo CR
Zyflo® CR (zileuton extended-release) Oral Hepatitis B Agents
• Formulary: Baraclude, Epivir HBV,
Baraclude® (entecavir), Epivir® HBV (lamivudine),
Hepsera® (adefovir dipivoxil), Tyzeka®
• Non-formulary: Hepsera, Tyzeka
(telbivudine), Viread® (tenofovir) Macrolide/Ketolide Antibiotics
• Formulary: azithromycin,
azithromycin, clarithromycin, clarithromycin ER,
erythromycin, Ketek®, PCE® Dispertab, Zmax®
• Non-formulary: clarithromycin ER, Multiple Sclerosis Drugs
• Formulary: Avonex, Betaseron,
Avonex® (interferon beta-1a [IM]), Betaseron®
(interferon beta-1b), Copaxone® (glatiramer acetate), Extavia® (interferon beta-1b), Rebif® (interferon beta-1a [SC]) Nasal Steroids
• Formulary: fluticasone propionate
Beconase® AQ (beclomethasone), flunisolide,
• Non-formulary: Beconase AQ,
(mometasone), Omnaris® (ciclesonide), Rhinocort® Aqua (budesonide), Veramyst® (fluticasone furoate)
Copayment/Coinsurance for all pharmaceuticals & pharmaceutical classes above:
• Healthy Options, Basic Health Plus, Children’s Health Insurance Program, & General Assistance Unemployable = $0 • Basic Health Plan = $10 copay for formulary generic products; 50% coinsurance for formulary brand products
720 Olive Way, Suite 300 Seattle WA 98101 | www.chpw.org | 1.800.440.1561 | 206.521.8833
Prior Authorization Criteria for:
• Abilify = trial of Seroquel or Seroquel XR first (step therapy; 2nd step); treatment of major depressive
disorder after trial of three antidepressants; treatment of irritability with autistic disorder after trial of risperidone or clinical concerns regarding use of risperidone first
• Adcirca = FDA-approved indications and not currently taking nitrates
• Cymbalta = Trial of a tricyclic antidepressant, gabapentin and an SSRI first for treatment of
fibromyalgia; trial of 2 formulary SSRIs and Effexor XR or 1 formulary SSRI and venlafaxine IR for treatment of depression; trial of gabapentin for the treatment of diabetic peripheral neuropathy
• Letairis = FDA-approved indications after trial of Adcirca or Revatio first (step therapy) unless
contraindication to Adcirca or Revatio; diagnosis of World Health Organization (WHO) class IV symptoms
• Revatio = FDA-approved indications and not currently taking nitrates
• Sabril = Treatment of refractory complex seizures after trial of ≥ 4 other antiepileptic drugs and infantile
• Samsca = FDA-approved indications
• Seroquel/Seroquel XR = trial of risperidone first (step therapy; 1st step) in patients < 65 years of age;
treatment of major depressive disorder after trial of three antidepressants; bipolar depression or depressive episodes associated with bipolar disorder
• Singulair = Covered for patients < 12 years of age; for non-asthmatic patients ≥ 12 years of age trial of
non-sedating antihistamine and nasal steroid first (step therapy); for asthmatic patients ≥ 12 years of age trial with an inhaled corticosteroid first (step therapy); interstitial cystitis if the patient has tried two alternative therapies for this condition
• Tracleer = FDA-approved indications after trial of Adcirca or Revatio first (step therapy) unless
contraindication to Adcirca or Revatio; diagnosis of World Health Organization (WHO) class IV symptoms
• Votrient = FDA-approved indications
• Zyprexa = trial of Seroquel or Seroquel XR first (step therapy; 2nd step)
720 Olive Way, Suite 300 Seattle WA 98101 | www.chpw.org | 1.800.440.1561 | 206.521.8833
Medizinische Notfälle in der Zahnarztpraxis Teure Geräte oder Medikamente (Verfalldatum!) werden im Postraum (N 102) bei derZentralen Anmeldung gelagert. In zwei deutlich gekennzeichneten (abschliessbaren)USM-Schränken sind ein Defibrillator, eine Absauganlage und eine Sauerstoffflascheuntergebracht. Defibrillator und Absaugvorrichtung sind mit einem Akku ausgerüstetund können dadurch ohne
NEWSLETTER JANUARY 2004 For reservations & all enquiries Telephone 020 7352 5953 Fax 020 7349 0655 Email: [email protected]; Web: www.606club.co.uk 90 Lots Road, London, SW10 0QD Well, Post Office willing (asking a lot, I know!), this letter and gig-guide should be with you before Xmas (efficient, huh!). So I still have time to remind you about our