Date Printed: 01/19/2007 Date Updated: 01/29/2006 Version 1.4
Section 1 - Product and Company Information
Product Name DILTIAZEM HYDROCHLORIDEProduct Number D2521Brand SIGMA
Company Sigma-AldrichAddress 3050 Spruce Street SAINT LOUIS MO 63103 USTechnical Phone: 800-325-5832Fax: 800-325-5052Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313DILTIAZEM HYDROCHLORIDE 33286-22-5 No
Formula C22H26N2O4S.ClHSynonyms Altiazem * Anginyl * Angizem * Britiazim * Bruzem * Calcicard * Cardizem * CRD-401 * Dilpral * Diltiazem chloridrate * Diltiazem hydrochloride * Dilzem * Herbesser * Masdil * TildiemRTECS Number: DL0310000
EMERGENCY OVERVIEW Harmful. Harmful if swallowed. Target organ(s): Cardiovascular system. Liver. Calif. Prop. 65 developmental hazard.
HMIS RATING HEALTH: 1* FLAMMABILITY: 0 REACTIVITY: 0
NFPA RATING HEALTH: 1 FLAMMABILITY: 0 REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician.
INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
EXTINGUISHING MEDIA Suitable: Carbon dioxide, dry chemical powder, or appropriate foam.
FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Emits toxic fumes under fire conditions.
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
HANDLING User Exposure: Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE Suitable: Keep tightly closed. Store at 2-8˚C
ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required.
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PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator. Hand: Compatible chemical-resistant gloves. Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES Wash thoroughly after handling.
Property Value At Temperature or Pressure
Molecular Weight 451 AMUpH N/ABP/BP Range N/AMP/MP Range 212 ˚CFreezing Point N/AVapor Pressure N/AVapor Density N/ASaturated Vapor Conc. N/ASG/Density N/ABulk Density N/AOdor Threshold N/AVolatile% N/AVOC Content N/AWater Content N/ASolvent Content N/AEvaporation Rate N/AViscosity N/ASurface Tension N/APartition Coefficient N/ADecomposition Temp. N/AFlash Point N/AExplosion Limits N/AFlammability N/AAutoignition Temp N/ARefractive Index N/AOptical Rotation N/AMiscellaneous Data N/ASolubility Solubility in Water:50 mg/ml H2O clear, very faintly yellow
STABILITY Stable: Stable. Conditions of Instability: Light. Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides, Hydrogen chloride gas.
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HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur
ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: Harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S) Liver. Cardiovascular system.
SIGNS AND SYMPTOMS OF EXPOSURE Other symptoms include orthostatic hypotension and bradycardia. Gastrointestinal disturbances. Exposure can cause:
Oral Man 21 mg/kg LDLO Remarks: Vascular:BP lowering not charactertized in autonomic section. Cardiac:Pulse rate. Cardiac:Cardiomyopathy including infarction.
Oral Woman 120 mg/kg LDLO Remarks: Cardiac:Cardiomyopathy including infarction.
Oral Rat 560 mg/kg LD50 Remarks: Behavioral:Antipsychotic.
Subcutaneous Rat 520 MG/KG LD50 Remarks: Behavioral:Antipsychotic.
Intravenous Rat 38 MG/KG LD50 Remarks: Behavioral:Somnolence (general depressed activity). Behavioral:Altered sleep time (including change in righting reflex). Behavioral:Tetany.
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Subcutaneous Mouse 260 MG/KG LD50 Remarks: Behavioral:Antipsychotic.
Intravenous Mouse 58 MG/KG LD50 Remarks: Behavioral:Antipsychotic.
Species: Rat Dose: 60 MG/KG Route of Application: Oral Exposure Time: (9-14D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. Effects on Newborn: Live birth index (# fetuses per litter; measured after birth).
Species: Rat Dose: 600 MG/KG Route of Application: Oral Exposure Time: (11D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat Dose: 480 MG/KG Route of Application: Intraperitoneal Exposure Time: (9-14D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Other developmental abnormalities.
Species: Mouse Dose: 25 MG/KG Route of Application: Oral Exposure Time: (9D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse Dose: 25 MG/KG Route of Application: Oral Exposure Time: (10D PREG) Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse Dose: 25 MG/KG Route of Application: Intraperitoneal Exposure Time: (9D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system.
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Species: Mouse Dose: 50 MG/KG Route of Application: Intraperitoneal Exposure Time: (9D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse Dose: 50 MG/KG Route of Application: Intraperitoneal Exposure Time: (13D PREG) Result: Specific Developmental Abnormalities: Other developmental abnormalities.
Species: Rat Dose: 1200 MG/KG Route of Application: Oral Exposure Time: (9-14D PREG) Result: Maternal Effects: Parturition. Effects on Embryo or Fetus: Fetal death.
Species: Rat Dose: 700 MG/KG Route of Application: Oral Exposure Time: (15-21D PREG) Result: Effects on Newborn: Stillbirth. Effects on Newborn: Growth statistics (e.g., reduced weight gain).
Species: Rat Dose: 80 MG/KG Route of Application: Intraperitoneal Exposure Time: (13D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Specific Developmental Abnormalities: Musculoskeletal system.
Species: Rat Dose: 130 MG/KG Route of Application: Intravenous Exposure Time: (17-21D PREG/21D POST) Result: Effects on Newborn: Stillbirth. Effects on Newborn: Growth statistics (e.g., reduced weight gain).
Species: Rat Dose: 378 MG/KG Route of Application: Intravenous Exposure Time: (14D PRE/1-7D PREG) Result: Effects on Fertility: Other measures of fertility
Species: Mouse Dose: 60 MG/KG Route of Application: Oral Exposure Time: (7-12D PREG) Result: Effects on Fertility: Litter size (e.g.; # fetuses per litter; measured before birth). Effects on Embryo or Fetus: Fetal death. Specific Developmental Abnormalities: Musculoskeletal system.
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Route of Application: Oral Exposure Time: (9D PREG) Result: Effects on Newborn: Sex ratio.
Species: Mouse Dose: 12500 UG/KG Route of Application: Intraperitoneal Exposure Time: (11D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Species: Rabbit Dose: 125 MG/KG Route of Application: Intraperitoneal Exposure Time: (7-16D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.
DOT Proper Shipping Name: None Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport.
IATA Non-Hazardous for Air Transport: Non-hazardous for air transport.
EU ADDITIONAL CLASSIFICATION Symbol of Danger: Xn Indication of Danger: Harmful. R: 22 Risk Statements: Harmful if swallowed. S: 36 Safety Statements: Wear suitable protective clothing.
US CLASSIFICATION AND LABEL TEXT Indication of Danger: Harmful. Risk Statements: Harmful if swallowed. Safety Statements: Wear suitable protective clothing. US Statements: Target organ(s): Cardiovascular system. Liver. Calif. Prop. 65 developmental hazard.
UNITED STATES REGULATORY INFORMATION SARA LISTED: No
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UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause developmental toxicity.
CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. DSL: No NDSL: No
DISCLAIMER For R&D use only. Not for drug, household or other uses.
WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
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