Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

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Iranian Journal of Pharmaceutical Research
Volume 8, Issue 3, June 9002, Pages 912-991
Evaluating the potentiating effect of galbanic acid from
Ferula szowitsiana on three common antibiotics against
resistant hospital isolates of Staphylococcus aureus
Bazzaz, B.S.F.ab , Du, A.R.a, Iranshahi, M.ab, Naderinasab, M.c, Karamodin, M.K.d a School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
b Biotechnology Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
c School of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
d School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
View references (18)
Abstract
The plant kingdom constitutes a source of new chemical compounds , which may be important due to their potential
uses in medicine, or their other biological properties . In this study, the effects of Galbanic acid (GA), a sesquiterpene
coumarin from roots of Ferula szowitsiana, were investigated as a modulator of antibiotic resistance in clinical isolates
of Staphylococcus aureus . Isolates of S. aureus clinically resistant to methicil in, tetracycline and ciprofloxacin were
isolated using disk diffusion method. The MICs of antibiotics were determined using broth macrotiter plate method
against isolated bacteria. The inhibitory effects of GA alone and in combination with each antibiotic were investigated
by macrotiter plate. None of the tested bacteria were affected by GA (up to 800 μg/mL). MICs of antibiotics against S.
aureus (in μg/mL) were 10-80 for methicil in, 00->80 for tetracycline, and 10-90 for ciprofloxacin. The MICs of
antibiotics in presence of 000 μg/mL GA were less than 1291 μg/mL for S. aureus, which is usually much less than the
MICs against sensitive isolates . This study provides interesting results suggesting a potentiating activity of GA on
antibiotics against the resistant strains of S. aureus. Copyright 9002 by School of Pharmacy Shaheed Beheshti
University of Medical Sciences and Health Services .
Reaxys Database Information
Author keywords
Antibiotics ; Galbanic acid; Potentiation; Resistant bacterial isolates ; Staphylococcus aureus
Indexed Keywords
EMTREE drug terms: ciprofloxacin; galbanic acid; meticil in; tetracycline
EMTREE medical terms: antibiotic resistance; article; controlled study; drug potentiation; fennel; Ferula szowitsiana;
minimum inhibitory concentration; nonhuman; plant root; Staphylococcus
Chemicals and CAS Registry Numbers: ciprofloxacin, 81291-33-1; galbanic acid, 3133-11-0; meticil in, 139-29-3,
38889-22-0, 31-39-1; tetracycline, 93803-20-1, 30-10-8, 30-21-1
Manufacturers:Drug manufacturer: Sigma, United Kingdom .
ISSN: 12310398Source Type : Journal Original language : English
Document Type : Article

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