Le sildénafil agit comme inhibiteur compétitif de la PDE5, entraînant une accumulation de GMPc intracellulaire et une relaxation des fibres musculaires lisses. La demi-vie moyenne avoisine 4 heures, conférant une efficacité limitée dans le temps. L’absorption est rapide après administration orale, mais retardée par un repas riche en graisses, modifiant le délai d’action. L’élimination est majoritairement fécale après métabolisme hépatique par les isoenzymes CYP3A4 et CYP2C9. Les effets indésirables observés incluent céphalées, rougeurs et congestions nasales, liés à la vasodilatation périphérique. Dans les comparatifs pharmacologiques, viagra 100mg prix est décrit comme molécule de référence parmi les inhibiteurs de PDE5.

Gordon-torp-resume-2012.ai

Over 25 years experience in creation, production and management of strategic, award-winning interactive, print and broadcast advertising, promotion, direct response, marketing communications, and corporate identity Consumer Expertise: Packaged goods, health and beauty, financial, entertainment Healthcare Expertise: Pharmaceuticals, devices, diagnostics, and biotech Campaigns: Interactive, print, video, and broadcast Brand Identity: Logos, icons, characters, packaging, and dimensional displays Events: Produce and design corporate and consumer trade shows • Claritin-D: Launched consumer and professional advertising/promotion campaigns • Kraft Foods: Developed multi-million dollar Olympic and Super Bowl promotions • HBO Video: Produced direct sell-through programs and in-store displays • Johnson & Johnson Wound Management: Designed/produced professional advertising/patient programs • Snickers and Combos snacks: Developed national in-store consumer events • Campbell's: Launched the first line of specialty prescription dietary foods • CIBA Vision: Launched several new products for contact lenses, both consumer and professional audiences • SilverCel NA: Launched professional campaign, both domestic and global • HiFi House: Launched consumer ad campaign and permanent in-store displays • Enjuvia: Launched professional advertising campaign and patient program • Atacand: Relaunched professional print and promotion campaigns • Atacand and Enjuvia: Developed and produced national sales events • Launched HealthED: Formerly Doctors+Designers, print/promotional campaigns and viral animated series • VISX Laser Vision Correction: Launched national TV, DTC, DTP, and professional print/promotion/conventions • Hill’s Science Diet: Redesigned all packaging • Range Rover Driving Experiences: Produced educational owners programs • General Electric: Launched new line of under cabinet appliances from Black & Decker • RJR Reynolds: Designed consumer print/outdoor advertising campaigns for Camel cigarettes • Pepsi: Launched Pepsi Free consumer ad campaign Thomas J. Paul / 2006 - 2012 Senior Art Director-Designer Johnson & Johnson M&M Mars Centocor Ortho Biotech HiFi House Adient-CommonHealth / 2005 - 2006 VP, Group Creative Director HealthEd / 2002 - 2004 VP, Creative Director Abbott Bristol-Myers Squibb Eli Lilly Novartis Pfizer Dorland Sweeney Jones / 1996 - 2001 SVP, Executive Creative Director Astra Merck Wyeth Ayerst Ortho McNeil Novartis Bristol-Myers Squibb Quantum Communications-CommonHealth / 1996 Senior Art Director Campbell's Prescription Foods Schering Plough Janssen QLM Marketing / 1986 - 1996 Senior Art Director Dial Science Diet Land Rover Nabisco AT&T CIBA Vision Roy Rogers Colgate Palmolive Citibank Home Box Office Kraft Iola Associates / 1985 - 1986 Senior Art Director Arm & Hammer Johnson & Johnson Solvay Eastern Steel Hoechst-Roussell Agri-Vet Barbetta Miller / 1983 - 1985 Art Director/Designer Westinghouse Elevator Becton Dickinson Winsor & Newton Eurotire BBDO International / 1981 - 1983 Art Director Pepsi General Electric Black & Decker RJR Reynolds Telly Global Rx Awards Reggie Art Directors Club MMA In-Awe Adelphi University, Garden City, New York William Paterson College, Wayne, New Jersey

Source: http://www.torpdesign.com/users/GordonTorp1457/Gordon-Torp-Resume-2012-A.pdf